Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture

BİNNETOGLU, Damla; ÇINAR, İRFAN; Yayla, Muhammed; Demirbağ, Çağlar

doi:10.33808/clinexphealthsci.797718

Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture

İRFAN ÇINAR, (Kastamonu Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Kastamonu, Türkiye)

Muhammed Yayla, (Kafkas Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Kars, Türkiye)

ÇAĞLAR DEMİRBAĞ, (Trakya Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Edirne, Türkiye)

Damla Binnetoglu (Kafkas Üniversitesi, Tıp Fakültesi, Farmakoloji Anabilim Dalı, Kars, Türkiye)

Clinical and Experimental Health Sciences

3 0

Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 59 - 64 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.797718 İndeks Tarihi: 12-01-2022

Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture

Öz:

Objective: Cancer is the most common cause of death after cardiovascular diseases. Cisplatin used in most types of cancer produces neurotoxicity. In thisstudy, we aimed to investigate the effects of pomegranate peel extract (1) in different doses, as potent antioxidants, on the prevention of neurotoxicity due to cisplatin, which is frequently used in cancer treatment. Methods: In our study, newborn rat cortex was used. 2 hours following the application of PPE at 200, 300 and 400 mg/mL, neurotoxicity was established by applying cisplatin in 50 and 100 µM concentrations. Results: In our study, cisplatin decreased cell viability in increasing doses, while PPE showed the best neuroprotective effect in high doses. Increased total oxidant capacity due to toxicity was significantly improved by PPE4. The antioxidant capacity decreased in the toxicity group showed improvement with the administration of PPE4. At the same time, increased TNF-α mRNA expression after cisplatin administration was significantly reduced with the administration of PPE4. The increased caspase 3 (CAS 3) and caspase 9 (CAS 9) mRNA expression due to cisplatin showed improvement with the administration of PPE4. Conclusion: These results indicated that PPE could inhibit cisplatin-induced neurotoxicity, and these effects may be related to anti-apoptotic and antioxidants activities.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÇINAR İ, Yayla M, Demirbağ Ç, BİNNETOGLU D (2021). Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. , 59 - 64. 10.33808/clinexphealthsci.797718
Chicago	ÇINAR İRFAN,Yayla Muhammed,Demirbağ Çağlar,BİNNETOGLU Damla Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. (2021): 59 - 64. 10.33808/clinexphealthsci.797718
MLA	ÇINAR İRFAN,Yayla Muhammed,Demirbağ Çağlar,BİNNETOGLU Damla Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. , 2021, ss.59 - 64. 10.33808/clinexphealthsci.797718
AMA	ÇINAR İ,Yayla M,Demirbağ Ç,BİNNETOGLU D Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. . 2021; 59 - 64. 10.33808/clinexphealthsci.797718
Vancouver	ÇINAR İ,Yayla M,Demirbağ Ç,BİNNETOGLU D Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. . 2021; 59 - 64. 10.33808/clinexphealthsci.797718
IEEE	ÇINAR İ,Yayla M,Demirbağ Ç,BİNNETOGLU D "Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture." , ss.59 - 64, 2021. 10.33808/clinexphealthsci.797718
ISNAD	ÇINAR, İRFAN vd. "Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture". (2021), 59-64. https://doi.org/10.33808/clinexphealthsci.797718

APA	ÇINAR İ, Yayla M, Demirbağ Ç, BİNNETOGLU D (2021). Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. Clinical and Experimental Health Sciences, 11(1), 59 - 64. 10.33808/clinexphealthsci.797718
Chicago	ÇINAR İRFAN,Yayla Muhammed,Demirbağ Çağlar,BİNNETOGLU Damla Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. Clinical and Experimental Health Sciences 11, no.1 (2021): 59 - 64. 10.33808/clinexphealthsci.797718
MLA	ÇINAR İRFAN,Yayla Muhammed,Demirbağ Çağlar,BİNNETOGLU Damla Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. Clinical and Experimental Health Sciences, vol.11, no.1, 2021, ss.59 - 64. 10.33808/clinexphealthsci.797718
AMA	ÇINAR İ,Yayla M,Demirbağ Ç,BİNNETOGLU D Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. Clinical and Experimental Health Sciences. 2021; 11(1): 59 - 64. 10.33808/clinexphealthsci.797718
Vancouver	ÇINAR İ,Yayla M,Demirbağ Ç,BİNNETOGLU D Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture. Clinical and Experimental Health Sciences. 2021; 11(1): 59 - 64. 10.33808/clinexphealthsci.797718
IEEE	ÇINAR İ,Yayla M,Demirbağ Ç,BİNNETOGLU D "Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture." Clinical and Experimental Health Sciences, 11, ss.59 - 64, 2021. 10.33808/clinexphealthsci.797718
ISNAD	ÇINAR, İRFAN vd. "Pomegranate Peel Extract Reduces Cisplatin-Induced Toxicity and Oxidative Stress in Primary Neuron Culture". Clinical and Experimental Health Sciences 11/1 (2021), 59-64. https://doi.org/10.33808/clinexphealthsci.797718