Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model
Yıl: 2020 Cilt: 58 Sayı: 4 Sayfa Aralığı: 241 - 248 Metin Dili: İngilizce İndeks Tarihi: 27-05-2022
Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model
Öz: Objective: This study aimed to explore whether carvacrol (CV) had a protective effect on paclitaxel-induced ototoxicity from biochemical, functional, and
histopathological perspectives.
Methods: Forty Wistar albino male rats were randomly separated into five groups of eight rats. Group
1 was the control group, so Paclitaxel or CV was not
administered. Group 2 was administered i.p. CV at 25
mg/kg once a week; Group 3, was administered i.p.
paclitaxel at 5 mg/kg once a week; Group 4 was administered i.p. paclitaxel at 5 mg/kg followed (30 min
later) by CV at 25 mg/kg once a week; and Group 5
was administered i.p. CV at 25 mg/kg followed (1 day
later) by paclitaxel at 5 mg/kg. once a week. The drugs
were administered intraperitoneally once a week for
four consecutive weeks, and distortion product otoacoustic emissions (DPOAE) tests were performed
at the beginning of the study before the first drug
administration and at the end of the study after the
last drug administration. All rats were sacrificed, and
cochleae were removed for biochemical and histopathological analysis.
Results: Biochemical data indicated that paclitaxel
caused oxidative stress in the cochlea. Histopathological findings revealed the loss of outer hair cells in
the organ of Corti (CO) and moderate degenerative
changes in the stria vascularis (SV). It was observed
that DPOAE measurements were significantly reduced at high frequencies. In groups which CV was
administered together with paclitaxel, these biochemical, histopathological, and functional changes were
favorably reversed.
Conclusion: CV may have a protective effect against
paclitaxel-induced ototoxicity when given.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık
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APA | ATALAY F, Tatar A, Dincer B, GÜNDOĞDU B, Köyceğiz S (2020). Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. , 241 - 248. |
Chicago | ATALAY Fatma,Tatar Arzu,Dincer Busra,GÜNDOĞDU BETÜL,Köyceğiz Sinan Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. (2020): 241 - 248. |
MLA | ATALAY Fatma,Tatar Arzu,Dincer Busra,GÜNDOĞDU BETÜL,Köyceğiz Sinan Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. , 2020, ss.241 - 248. |
AMA | ATALAY F,Tatar A,Dincer B,GÜNDOĞDU B,Köyceğiz S Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. . 2020; 241 - 248. |
Vancouver | ATALAY F,Tatar A,Dincer B,GÜNDOĞDU B,Köyceğiz S Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. . 2020; 241 - 248. |
IEEE | ATALAY F,Tatar A,Dincer B,GÜNDOĞDU B,Köyceğiz S "Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model." , ss.241 - 248, 2020. |
ISNAD | ATALAY, Fatma vd. "Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model". (2020), 241-248. |
APA | ATALAY F, Tatar A, Dincer B, GÜNDOĞDU B, Köyceğiz S (2020). Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. Turkish archives of otorhinolaryngology , 58(4), 241 - 248. |
Chicago | ATALAY Fatma,Tatar Arzu,Dincer Busra,GÜNDOĞDU BETÜL,Köyceğiz Sinan Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. Turkish archives of otorhinolaryngology 58, no.4 (2020): 241 - 248. |
MLA | ATALAY Fatma,Tatar Arzu,Dincer Busra,GÜNDOĞDU BETÜL,Köyceğiz Sinan Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. Turkish archives of otorhinolaryngology , vol.58, no.4, 2020, ss.241 - 248. |
AMA | ATALAY F,Tatar A,Dincer B,GÜNDOĞDU B,Köyceğiz S Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. Turkish archives of otorhinolaryngology . 2020; 58(4): 241 - 248. |
Vancouver | ATALAY F,Tatar A,Dincer B,GÜNDOĞDU B,Köyceğiz S Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model. Turkish archives of otorhinolaryngology . 2020; 58(4): 241 - 248. |
IEEE | ATALAY F,Tatar A,Dincer B,GÜNDOĞDU B,Köyceğiz S "Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model." Turkish archives of otorhinolaryngology , 58, ss.241 - 248, 2020. |
ISNAD | ATALAY, Fatma vd. "Protective Effect of Carvacrol against Paclitaxel-Induced Ototoxicity in Rat Model". Turkish archives of otorhinolaryngology 58/4 (2020), 241-248. |