TY  - JOUR
TI  - Antihyperglycemic and neuroprotective activity of
Adenanthera pavonina bark against streptozotocin
induced diabetic rats
AB  - Worldwide diabetes and diabetic neuropathy is the highly prevalent healthcare problem. Herbal based
therapy is an alternative and safe management of this problem. Adenanthera pavonina is an important medicinal plant
having many of the medicinal values. This research aimed to evaluate the antihyperglycemic and neuroprotective
activity of bark of Adenanthera pavonina. Hydro alcohol (50% methanol) was used as the solvent for extraction.
Streptozotocin (55 mg/kg, i.p) induced diabetic rats were used for the evaluation of antihyperglycemic and
neuroprotective activity. Diabetic rats were treated with hydro alcoholic bark extract of Adenanthera pavonina
(HABEA) for 21 days. After treatment period blood glucose levels, SGOT, SGPT, Glutamate and Lipid peroxidase
levels were decreased significantly in HABEA (200 and 400 mg/kg, p.o) treated rats. However, body weight,
Serotonin, GABA, total protein and reduced glutathione levels were increased. And also behavioral parameter such as
pain behavior (Hot Plate Method and Tail Immersion Method) and locomotor behavior (actophotometer) were
significantly improved in HABEA (200 and 400 mg/kg, p.o) treated rats. These are the findings confirms that, the
HABEA has significant antihyperglycemic and neuroprotective activity. Alkaloids, glycosides, flavonoids, saponin,
phenolics and phytosterol present in the bark of Adenanthera pavonina may be the reason for its antihyperglycemic and
neuroprotective activity. Further, this research will useful for the isolation of active principles from HABEA and
determining its molecular mechanisms
AU  - K, GOPALASATHEESKUMAR
AU  - ABARNADEVIKA, Alagiri
AU  - K, Kavitha
DO  - 10.29228/jrp.111
PY  - 2022
JO  - Journal of research in pharmacy (online)
VL  - 26
IS  - 1
SN  - 2630-6344
SP  - 145
EP  - 153
DB  - TRDizin
UR  - http://search/yayin/detay/520457
ER  -