Objective: This prospective, randomized clinical trial aimed to investigate the effects of mouthwashes with different ingredients on pain, edema, trismus, and postoperative mucosal healing following surgical removal of impacted mandibular third molars. Material and Methods: Sixty participants, aged between 18-47, with impacted mandibular third molars, which had moderate surgical difficulty according to the Pederson difficulty index, were included. Participants were randomly divided into 3 groups, each containing 20 patients. In the first group Benzydamine HCl (0.15%)+ Chlorhexidine Gluconate (0.12%), in the second group Zinc Chloride (ZnCl2) (0.02%)+Boric Acid (H3BO3) (0.01%), and in the third group Propolis (1%)+Chlorhexidine Gluconate (0.02%) containing mouthwashes were prescribed. Maximum mouth opening, edema, pain measurements, and early healing index scores were examined pre- and postoperatively on the second and seventh days. Results: Significant differences were observed between the 1st, 2nd, and 3rd groups’ pain (p=0.000 and p=0.022) and early healing index scores (p=0.018, p=0.002) in the postoperative second and seventh days. Also, maximum mouth opening measurements of the 1st, 2nd, and 3rd groups significantly differed on the postoperative second day (p=0.020), but the differences were insignificant on the postoperative seventh day (p=0.425). In edema measurements, no significant difference was observed between the groups, neither on the postoperative second day nor on the seventh day. Conclusion: It has been observed that postoperative routine use of mouthwashes with different ingredients, which have been evaluated regarding inflammatory complications and wound healing activities that occur following surgical removal of mandibular third molars, can reveal positive effects.