Cold urticaria (CU) is a subtype of physical urticaria characterized by the development of urticaria and angioedema after cold exposure. Symptoms typically ocur minutes after skin exposure to anything cold like air, liquid or an object. Ice cube challange test is commonly used method to confirm the diagnosis of CU. The major complication of CU is anaphylaxis. In all CU cases, even in testing, it is important that anaphylaxis should be kept in mind, and special precautions should be taken. We wanted to report as the first known case of anaphylaxis which is occured in during the ice cube challenge test in the published literature.