Aim: This case report demonstrates the application of piezocision in correcting persistent crowding in the lower anterior region of dental arch. Methodology: A female aged 14 years and 3 months presented to the Selçuk University, Faculty of Dentistry, Department of Orthodontics due to esthetic complaints. Clinical and radiological examination revealed crowding in the upper and lower dental arches as well as skeletal and dental Class I malocclusion. First, bonding and arch wire were applied to the patient’s upper jaw. The patient then had check-up appointments at 4-week intervals. In the second session, bonding was applied to the lower jaw. As the leveling was completed in the upper jaw, thicker arch wires were used. However, 4 months after the bonding of the lower anterior region, leveling did not occur. Consequently, piezocision was applied to the lower anterior region. Then, two applications of 0.014'' and 0.016'' Ni- Ti wire were carried out, respectively. After the completion of the leveling, intrusion was provided with the utility arch placed on the lower incisor brackets. Orthodontic treatment was concluded with the use of Ni- Ti and steel angle wires. Conclusion: Efficient leveling was achieved in the lower anterior region with piezocision applications.