An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study
Yıl: 2020 Cilt: 7 Sayı: 1 Sayfa Aralığı: 1 - 10 Metin Dili: İngilizce DOI: 10.4274/jtsm.galenos.2020.19484 İndeks Tarihi: 27-07-2022
An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study
Öz: Objective: The aim of this study was to assess the effect on various
systems of increased Obstructive Sleep Apnea syndrome (OSAS) severity,
defined with the Apnea-hypopnea index (AHI).
Materials and Methods: The study was conducted on 245 patients
who met the inclusion criteria. A total of 8 non-obese obese and obese
non-obese groups were formed. There were the non-obese control
group [AHI<5, Body Mass index (BMI) ≤29.9 kg/m2 (n=32)], obese
control group [AHI<5, BMI>30 kg/m2 (n=28)], non-obese mild OSAS
group [AHI 5-15, BMI≤29.9 kg/m2 (n=33)], obese mild OSAS group
[AHI 5-15, BMI>30 kg/m2 (n=26)], non-obese moderate OSAS group
[AHI 15-30, BMI≤29.9 kg/m2 (n=41)], obese moderate OSAS group [AHI
15-30, BMI>30 kg/m2 (n=24)], non-obese severe OSAS group [AHI>
30, BMI≤29.9 kg/m2 (n=38)], and obese severe OSAS group [AHI>30,
BMI>30 kg/m2 (n=23)].
Results: A statistically significantly greater difference was determined
between the groups in respect of the monocyte HDL cholesterol ratio
(MHR), monocyte LDL cholesterol ratio (MLR) and uric acid excretion
(UAE) values together with an increase in the severity of OSAS (p<0.001,
p<0.001 and p=0.006, respectively).
There was a positive correlation of OSAS severity with MHR (r=0.671,
p=0.001), UAE (r=0.467, p=0.001) and triglyceride (r=0.304, p=0.001)
values and a negative correlation with MLR (r=-0.213, p=0.001) and
HDL cholesterol (r=-0.285, p=0.001) values. Linear regression analysis
identified that triglycerides (mg/dL), UA excretion (mg/dL), neutrophil
lymphocyte ratio, MHR and MLR significantly contributed to OSAS
severity.
Conclusion: The increasing severity of OSAS, which has a multifactorial
etiology, affects many systems, primarily the inflammatory and cardiac
systems.
Anahtar Kelime: Obstrüktif Uyku Apne Sendromlu Erişkin Hastalarda Hematolojik, Biyokimyasal ve Hormon Değerleri ile Hastalık Şiddeti Arasındaki İlişkinin Değerlendirilmesi: Kesitsel Bir Çalışma
Öz: Amaç: Bu çalışmada, Apne-hipopne indeksi (AHİ) ile tanımlanan
Obstrüktif Uyku Apne sendromu (OSAS) şiddetindeki artışın farklı
sistemler üzerine olan etkilerinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Çalışma, dahil edilme şartlarını karşılayan toplam 245
hasta üzerinde yapıldı. Hastalar, hastalık şiddeti ve Vücut Kitle İndeksi
(VKİ) değerleri göz önünde bulundurularak obez ve non-obez toplam 8
gruba ayrıldı. Non-obez kontrol grubu [AHİ<5, VKİ≤29,9 kg/m2 (n=32)];
obez kontrol grubu [AHİ<5, VKİ>30 kg/m2 (n=28)]; non-obez hafif OSAS
grubu [AHİ 5-15, VKİ≤29,9 kg/m2 (n=33)]; obez hafif OSAS grubu [AHİ
5-15, VKİ>30 kg/m2 (n=26)]; non-obez orta şiddette OSAS grubu [AHİ
15-30, VKİ≤29,9 kg/m2 (n=41)]; obez orta şiddette OSAS grubu [AHİ
15-30, VKİ>30 kg/m2 (n=24)]; non-obez ciddi OSAS grubu [AHİ>30,
VKİ≤29,9 kg/m2 (n=38)]; obez ciddi OSAS grubu [AHİ>30, VKİ>30 kg/
m2 (n=23)].
Bulgular: Gruplar arasında monosit HDL kolesterol oranı (MHRs),
monosit LDL kolesterol oranı (MLRs) ve ürik asit ekskresyon (UAE)
değerlerindeki farkın, OSAS şiddeti artışı ile anlamlı oranda arttığı
görüldü (sırasıyla p<0,001, p<0,001 ve p=0,006). OSAS şiddeti ile
biyokimyasal ve hemotolojik parametreler arasındaki ilişki korelasyon
analizleriyle değerlendirildiğinde MHRs (r=0,671, p=0,001) ve UAE
(r=0,467, p=0,001) ve trigliserid (r=0,304, p=0,001) değerleri ile pozitif
korelasyon olduğu, MLRs (r=-0,213, p=0,001) ve HDL kolesterol (r=-
0,285, p=0,001) değerleri ile de negatif korelasyon olduğu görüldü.
Lineer regresyon analizlerinde trigliserid (mg/dL), UA ekskresyon (mg/
dL), nötrofil lenfosit oranı, MHRs ve MLRs değerlerinin OSAS şiddetine
anlamlı katkı sağladığı tespit edildi.
Sonuç: Multifaktöriyel etiyolojiye sahip olan OSAS, artan şiddetiyle
birlikte başta enflamatuvar ve kardiyak olmak üzere pek çok sistemi de
etkilemektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Avcu M, METİN M, soyalıç h, ilanbey B, tuna e (2020). An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. , 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| Chicago | Avcu Mustafa,METİN MEHMET,soyalıç harun,ilanbey Bilal,tuna elvan evrim An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. (2020): 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| MLA | Avcu Mustafa,METİN MEHMET,soyalıç harun,ilanbey Bilal,tuna elvan evrim An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. , 2020, ss.1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| AMA | Avcu M,METİN M,soyalıç h,ilanbey B,tuna e An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. . 2020; 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| Vancouver | Avcu M,METİN M,soyalıç h,ilanbey B,tuna e An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. . 2020; 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| IEEE | Avcu M,METİN M,soyalıç h,ilanbey B,tuna e "An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study." , ss.1 - 10, 2020. 10.4274/jtsm.galenos.2020.19484 |
| ISNAD | Avcu, Mustafa vd. "An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study". (2020), 1-10. https://doi.org/10.4274/jtsm.galenos.2020.19484 |
| APA | Avcu M, METİN M, soyalıç h, ilanbey B, tuna e (2020). An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. Türk Uyku Tıbbı Dergisi, 7(1), 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| Chicago | Avcu Mustafa,METİN MEHMET,soyalıç harun,ilanbey Bilal,tuna elvan evrim An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. Türk Uyku Tıbbı Dergisi 7, no.1 (2020): 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| MLA | Avcu Mustafa,METİN MEHMET,soyalıç harun,ilanbey Bilal,tuna elvan evrim An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. Türk Uyku Tıbbı Dergisi, vol.7, no.1, 2020, ss.1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| AMA | Avcu M,METİN M,soyalıç h,ilanbey B,tuna e An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. Türk Uyku Tıbbı Dergisi. 2020; 7(1): 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| Vancouver | Avcu M,METİN M,soyalıç h,ilanbey B,tuna e An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study. Türk Uyku Tıbbı Dergisi. 2020; 7(1): 1 - 10. 10.4274/jtsm.galenos.2020.19484 |
| IEEE | Avcu M,METİN M,soyalıç h,ilanbey B,tuna e "An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study." Türk Uyku Tıbbı Dergisi, 7, ss.1 - 10, 2020. 10.4274/jtsm.galenos.2020.19484 |
| ISNAD | Avcu, Mustafa vd. "An Evaluation of the Relationship Between Disease Severity and the Hematological, Biochemical and Hormone Values in Adult Patients with Obstructive Sleep Apnea Syndrome: A Cross-sectional Study". Türk Uyku Tıbbı Dergisi 7/1 (2020), 1-10. https://doi.org/10.4274/jtsm.galenos.2020.19484 |
