Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia

Güldür, Tayfun; KOÇER, Muzaffer; CERAN OZCAN, CANAN; BEKER AKBULUT, GÜLÇİN; KAYNAR, ÖZGÜR; BAYRAKTAR, Nihayet

Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia

Tayfun GÜLDÜR, (İnönü Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Malatya, Türkiye)

Nihayet BAYRAKTAR, (İnönü Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Malatya, Türkiye)

Özgür KAYNAR, (Atatürk Üniversitesi Veteriner Fakültesi.,Erzurum)

GÜLÇİN BEKER AKBULUT, (İnönü Üniversitesi, Fen Edebiyat Fakültesi, Botanik Bölümü, Malatya, Türkiye)

Muzaffer KOÇER, (İnönü Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Malatya, Türkiye)

Hamdi ÖZCAN (İnönü Üniversitesi, Tıp Fakültesi, Dermatoloji Anabilim Dalı, Malatya, Türkiye)

Turkish Journal of Medical Sciences

1 0

Yıl: 2007 Cilt: 37 Sayı: 4 Sayfa Aralığı: 205 - 211 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia

Öz:

Amaç: Deri yüzey lipidlerinin çoğu sebum olarak adlandırılan yağlı bir maddeyi salgılayan yağ bezlerinden köken almaktadır. Sebum lipidlerinin bir kısmı yağ bezi hücreleri tarafından sentezlenirken diğer bir kısmının ise plazmadan kaynaklanabileceği bildirilmiştir. Kan lipoproteinlerinin sebum sekresyon hızı ve kompozisyonundaki rolü açık değildir. Bu amaçla, normo- ve tip IV hiperlipoproteinemili erişkin erkeklerde deri yüzey lipidlerinin ekskresyon hızı ve kompozisyonu karşılaştırıldı. Yöntem ve Gereç: Tip IV hiperlipoproteinemili (n:21) ve normolipoproteinemililerde (n:15) deri yüzey lipidlerinin kantitatif analizi, alnın sağ, sol ve orta bölgesinde yapılan sebumetrik ölçümlerle gerçekleştirildi. Deri yüzey lipidlerinin kompozisyonel analizi için numuneler alın bölgesinden n-hekzan ile ekstrakte edilerek elde edildi ve yüksek performanslı ince tabaka kromatografisi (HPTLC) ile analiz edildi. Bulgular: Tip IV hiperlipoproteinemili erişkin erkeklerde deri yüzey lipidlerinin normolipoproteinemililere göre daha yüksek oranda mum esteri + kolesteril esteri içerdiği tespit edildi (p:0.004). Bununla beraber, ekskresyon hızlarında istatiksel olarak önemli bir fark tespit edilemedi. Sonuç: Plazma triaçilgliserol konsantrasyonu sebum mum esteri+kolesteril esteri içeriğini etkileyebilmektedir.

Anahtar Kelime:

Konular: Cerrahi

Tip IV hiperlipoproteinemili erişkin erkeklerde alın bölgesi deri yüzey lipidlerinin ekskresyon hızı ve kompozisyonu

Öz:

Aim: Most of the lipids of the skin surface come from the sebaceous glands, which secrete an oily substance called sebum. Some of the sebum lipids are synthesized by sebaceous cells while some are reported to be derived from the plasma. The role of blood lipoproteins in sebum secretion rate and composition is unclear. To this end, excretion rate and composition of skin surface lipids in normo- and type IV hyperlipoproteinemic adult male subjects were compared. Materials and Methods: Quantitative analysis of skin surface lipids of subjects with type IV hyperlipoproteinemia (n:21) and normolipoproteinemia (n:15) was performed by three successive samplings from left, middle and right zones of the forehead with a sebumeter. Skin surface lipid samples for the compositional analysis were collected from the forehead, extracted into nhexane and analyzed by high performance thin layer chromatography (HPTLC). Results: Skin surface lipids from type IV hyperlipoproteinemic subjects contained a higher proportion of wax ester + cholesteryl ester compared with normolipoproteinemic subjects (p:0.004). However, skin surface lipid excretion rates of normo- and hyperlipoproteinemic subjects were found to be similar.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Nicolaides N. Skin lipids: their biochemical uniqueness. Science 1974; 186: 19-26.
2. Thody AJ, Shuster S. Control and function of sebaceous glands. Physiological Reviews 1989; 69: 383-416.
3. Pochi PE, Strauss JS. Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol 1974; 62: 191-201.
4. Pochi PE, Strauss JS, Downing DT. Age-related changes in sebaceous gland activity. J Invest Dermatol 1979; 73: 108-111.
5. Strauss JS, Pochi PE. The quantitative gravimetric determination of sebum production. J Invest Dermatol 1961; 36: 293-298.
6. Stewart ML, Steele WA, Downing DT. Changes in the relative amounts of endogenous and exogenous fatty acids in sebaceous lipids during early adolescence. J Invest Dermatol 1989; 92: 371- 378.
7. Nikkari T, Schreibman PH, Ahrens H. Isotope kinetics of human skin cholesterol secretion. J Exp Med 1975; 141: 620-634.
8. Jong MC, Gijbels MJJ, Dahlmans VEH, van Gorp PJJ, Kopman SJ, Ponec M et al. Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1. J Clin Invest 1998; 101: 145-152.
9. Fex GA, Aronsson A, Andersson A, Larsson K, Nilsson-Ehle P. In vivo effects of 13-cis retinoic acid treatment on the concentration of proteins and lipids in serum. Eur J Clin Chem Clin Biochem 1996; 34: 3-7.
10. Laker MF, Green C, Bhuiyan AK, Shuster S. Isotretinoin and serum lipids: studies on fatty acid, apolipoprotein and intermediary metabolism. Br J Dermatol 1987; 117: 203-206.
11. Rifal N, Bachorik PS, Albers JJ. Lipids, lipoproteins and apolipoproteins. In: Burtis CA, Ashwood E, editors. Tietz textbook of clinical chemistry. 3rd ed. USA: WB Saunders Company; 1999. p. 831.
12. Röpke EM, Augustin W, Gollnick H. Improved method for studying skin lipid samples from cyanoacrylate strips by high performance thin layer chromatography. Skin Pharmacol 1996; 9: 381-387.
13. Menlik BC, Hollmann J, Erler E, Verhoeven B, Plewig G. Microanalytical screening of all major stratum corneum lipids by sequential high-performance thin-layer chromatography. J Invest Dermatol 1989; 92: 231-234.
14. Strauss JS, Pochi PE, Downing DT. The sebaceous glands: twenty-five years of progress. J Invest Dermatol 1976; 67: 90- 97.
15. Nordstrom KM, Schmus HG, McGinley KJ, Leyden JJ. Measurement of sebum output using a lipid absorbent tape. J Invest Dermatol 1986; 87: 260-263.
16. Guy R, Ridden C, Kealey T. The improved organ maintenance of the human sebaceous gland: modeling in vitro the effects of epidermal growth factor, androgens, estrogens, 13-cis retinoic acid, and phenol red. J Invest Dermatol 1996; 106: 454-460.
17. Stewart ME, Downing DT, Pochi PE, Strauss JS. The fatty acids of human sebaceous gland phosphatidylcholine. Biochimica et Biophysica Acta 1978; 529: 380-386.
18. Ebling FJ. Hormonal control and methods of measuring sebaceous gland activity. J Invest Dermatol 1974; 62: 161-171.
19. Shuster S, Thody AJ. The control and measurement of sebum secretion. J Invest Dermatol 1974; 62: 172-190.
20. Cooper MF, McGrath H, Shuster S. Sebaceous lipogenesis in human skin. Br J Dermatol 1976; 94:165-172.
21. Cheng JB, Russell DW. Mammalian wax biosynthesis: I. Identification of two fatty acyl-coenzyme A reductases with different substrate specificities and tissue distributions. J Biol Chem 2004; 279: 37789-37797.
22. Cheng JB, Russell DW. Mammalian wax biosynthesis: II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. J Biol Chem 2004; 279: 37798-37807.
23. Stalenhoef AF, Demacker PN, Lutterman JA, van’t Laar A. Plasma lipoproteins, apolipoproteins, and triglyceride metabolism in familial hypertriglyceridemia. Arteriosclerosis 1986; 6: 387-394.
24. Packard CJ, Shepherd J, Joerns S, Gotto AM, Taunton OD. Apolipoprotein B metabolism in normal, type IV, and type V hyperlipoproteinemic subjects. Metabolism 1980; 29: 213-222.
25. Brunzell JD, Albers JJ, Chait A, Grundy SM. Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia. J Lipid Res 1983; 24: 147-155.
26. Brook JG, Lavy A, Aviram M, Zinder O. The concentration of high density lipoprotein in patients with type IV hyperlipoproteinemia and effect of clofibrate. Atherosclerosis 1980; 36: 461-469.
27. Smythe CDW, Greenall M, Kealey T. The activity of HMG-CoA reductase and acetyl-CoA carboxylase in human apocrine sweat glands, sebaceous glands, and hair follicles is regulated by phosphorylation and by exogenous cholesterol. J Invest Dermatol 1998; 111: 139-148.
28. Cunliffe WJ, Shuster S. The effect of inhibitors of cholesterol synthesis on sebum secretion in patients with acne. Br J Derm 1969; 81: 280-282.
29. Marcoux CM, Tremblay M, Nakajima K, Davignon J, Cohn JS. Characterization of remnant like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients. J Lipid Res 1999; 40: 636-647.
30. Marcoux C, Tremblay M, Fredenrich A, Jacques H, Krimbou L, Nakajima K, Davignon J, Cohn JS. Plasma remnant like particle lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. Atherosclerosis 1998; 139: 161-171.

APA	Güldür T, BAYRAKTAR N, KAYNAR Ö, BEKER AKBULUT G, KOÇER M, CERAN OZCAN C (2007). Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. , 205 - 211.
Chicago	Güldür Tayfun,BAYRAKTAR Nihayet,KAYNAR ÖZGÜR,BEKER AKBULUT GÜLÇİN,KOÇER Muzaffer,CERAN OZCAN CANAN Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. (2007): 205 - 211.
MLA	Güldür Tayfun,BAYRAKTAR Nihayet,KAYNAR ÖZGÜR,BEKER AKBULUT GÜLÇİN,KOÇER Muzaffer,CERAN OZCAN CANAN Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. , 2007, ss.205 - 211.
AMA	Güldür T,BAYRAKTAR N,KAYNAR Ö,BEKER AKBULUT G,KOÇER M,CERAN OZCAN C Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. . 2007; 205 - 211.
Vancouver	Güldür T,BAYRAKTAR N,KAYNAR Ö,BEKER AKBULUT G,KOÇER M,CERAN OZCAN C Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. . 2007; 205 - 211.
IEEE	Güldür T,BAYRAKTAR N,KAYNAR Ö,BEKER AKBULUT G,KOÇER M,CERAN OZCAN C "Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia." , ss.205 - 211, 2007.
ISNAD	Güldür, Tayfun vd. "Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia". (2007), 205-211.

APA	Güldür T, BAYRAKTAR N, KAYNAR Ö, BEKER AKBULUT G, KOÇER M, CERAN OZCAN C (2007). Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. Turkish Journal of Medical Sciences, 37(4), 205 - 211.
Chicago	Güldür Tayfun,BAYRAKTAR Nihayet,KAYNAR ÖZGÜR,BEKER AKBULUT GÜLÇİN,KOÇER Muzaffer,CERAN OZCAN CANAN Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. Turkish Journal of Medical Sciences 37, no.4 (2007): 205 - 211.
MLA	Güldür Tayfun,BAYRAKTAR Nihayet,KAYNAR ÖZGÜR,BEKER AKBULUT GÜLÇİN,KOÇER Muzaffer,CERAN OZCAN CANAN Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. Turkish Journal of Medical Sciences, vol.37, no.4, 2007, ss.205 - 211.
AMA	Güldür T,BAYRAKTAR N,KAYNAR Ö,BEKER AKBULUT G,KOÇER M,CERAN OZCAN C Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. Turkish Journal of Medical Sciences. 2007; 37(4): 205 - 211.
Vancouver	Güldür T,BAYRAKTAR N,KAYNAR Ö,BEKER AKBULUT G,KOÇER M,CERAN OZCAN C Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia. Turkish Journal of Medical Sciences. 2007; 37(4): 205 - 211.
IEEE	Güldür T,BAYRAKTAR N,KAYNAR Ö,BEKER AKBULUT G,KOÇER M,CERAN OZCAN C "Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia." Turkish Journal of Medical Sciences, 37, ss.205 - 211, 2007.
ISNAD	Güldür, Tayfun vd. "Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia". Turkish Journal of Medical Sciences 37/4 (2007), 205-211.