PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population

Eser Y. SÖZMEN, (Ege Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir, Türkiye)
Meral KAYIKÇIOĞLU, (Ege Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)
Ebru SEZER, (Ege Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir, Türkiye)
Bilal İLANBEY, (Yozgat Devlet Hastanesi, Yozgat, Türkiye)
Yasemin D. AKÇAY, (Ege Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir, Türkiye)
Hakan KÜLTÜRSAY (Ege Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye)
Türk Biyokimya Dergisi
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Yıl: 2009 Cilt: 34 Sayı: 4 Sayfa Aralığı: 250 - 255 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population

Öz:
Amaç: Kardiyovasküler hastalık risk faktörü olarak paraoksonaz1 (PON1) polimorfizminin rolüyle ilgili çok sayıda çelişkili rapor bulunmaktadır. Koroner arter hastalığı ilePON1-55L ya da PON1-192R alelleri arasında ilişki olduğu öne sürülmüştür. Diğer yandan son yayınlarda farklı popülasyonların PON1 aktivitesi ve konsantrasyonları arasında büyük farklılıklar olduğu gösterilmiştir. Bu çalışmada PON192 polimorfizmine göredüşük-dansiteli-lipoprotein (LDL) oksidasyon belirteçleri ve PON1 aktivitelerinin (paraoksonaz ve aril esteraz) özellikle Türk popülasyonunda koroner arter hastalığı bulunan gençlerde bu hastalık açısından yararlı belirteçler olup olmadıklarının araştırılması amaçlandı. Gereç ve Yöntem: Koroner arter hastalığı olan 60 hasta (38.1±5.0 yaşında) ve 52 sağlıklı kontrol (32.5±6.1 yaşında) çalışmaya alındı. Tüm hastalarda PON192 polimorfizmi, paraoksonaz aktivitesi, serum oksidasyon düzeyi belirlendi.Bulgular: Koroner arter hastalarında total kolesterol, trigliserid, bazal-dien ve stimüle-LDL tiobarbitürik asidle reaksiyon veren yapıların (TBARS) düzeyleri kontrolleregöre yüksek bulunurken PON1 ve arilesteraz aktivitelerinin düşük olduğu tespit edildi (p<0.001). Kontrol grubu içinde bakılan hiçbir parametrede polimorfizm açısındanbir farklılık saptanmazken, RR polimorfizmlilerde stimüle LDL-TBARS düzeylerinindaha yüksek olduğu görüldü (RR için 5,27 ± 2,4 nmol/mg LDL protein, QR için 3,64 ±1.28 nmol/mg LDL protein for QR ve QQ için 4,95 ± 2,8 nmol/mg LDLprotein). RR polimorfizmine hasta grubunda daha sık rastlanmakla birlikte istatistiksel anlamlılık saptanamadı. Sonuç: Bulgularımız RR polimorfizminin erken yaşlarda aterosklerozun belirlenebilmesi için yararlı bir gösterge olabileceğini düşündürmektedir.
Anahtar Kelime:

Konular: Biyokimya ve Moleküler Biyoloji

Genç türk popülasyonunda koroner arter hastalığı risk faktörü olarak PON192 polimorfizmi ve LDL-oksidasyonu

Öz:
Purpose: There are conflicting reports on paraoxonase1 (PON1) polymorphism as arisk factor for cardiovascular disease. It&#8217;s been proposed that there is relationship between coronary artery disease and PON1-55L or PON1-192R alleles. Nevertheless recentpublications showed major differences of PON1 activity and concentration in differentpopulations. We aimed to study low-density-lipoprotein (LDL) oxidation and PON1 activities (paraoxonase/arylesterase) regarding to PON192 polymorphism, in order to determine if they might be useful markers especially for young patients with coronary artery disease in Turkish population. Methods: 60 patients (38.1±5.0 years) with coronary artery disease and 52 healthy control subjects (32.5±6.1 years) were taken into study. Paraoxonase192 polymorphism, paraoxonase activity and oxidation status of all patients were analyzed. Results: Total cholesterol, triglyceride, basal-LDL-diene and stimulatedLDL-TBARSlevels were higher, paraoxonase and arylesterase activities were lower in patients withcoronary artery disease compared to controls(p<0.001). While there was no difference in any parameters within control group in regard to polymorphism, stimulated-LDLTBARS levels were higher in patients with RR polymorphism (5,27±2,4nmol/mg LDLprotein for RR; 3,64±1.28nmol/mg LDL protein for QR and 4,95±2,8nmol/mg LDL protein for QQ). RR polymorphism was more common in patient group than controls butnot statistically significant. Conclusion: Our data suggest that presence of RR polymorphism might be a predictivemarker for determination of atherosclerosis in early ages.
Anahtar Kelime:

Konular: Biyokimya ve Moleküler Biyoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SÖZMEN E, Kayikcioglu M, SEZER E, İLANBEY B, AKÇAY Y, KULTURSAY H (2009). PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. , 250 - 255.
Chicago SÖZMEN Eser Y.,Kayikcioglu Meral,SEZER Ebru,İLANBEY BİLAL,AKÇAY Yasemin D.,KULTURSAY HAKAN PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. (2009): 250 - 255.
MLA SÖZMEN Eser Y.,Kayikcioglu Meral,SEZER Ebru,İLANBEY BİLAL,AKÇAY Yasemin D.,KULTURSAY HAKAN PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. , 2009, ss.250 - 255.
AMA SÖZMEN E,Kayikcioglu M,SEZER E,İLANBEY B,AKÇAY Y,KULTURSAY H PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. . 2009; 250 - 255.
Vancouver SÖZMEN E,Kayikcioglu M,SEZER E,İLANBEY B,AKÇAY Y,KULTURSAY H PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. . 2009; 250 - 255.
IEEE SÖZMEN E,Kayikcioglu M,SEZER E,İLANBEY B,AKÇAY Y,KULTURSAY H "PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population." , ss.250 - 255, 2009.
ISNAD SÖZMEN, Eser Y. vd. "PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population". (2009), 250-255.
APA SÖZMEN E, Kayikcioglu M, SEZER E, İLANBEY B, AKÇAY Y, KULTURSAY H (2009). PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. Türk Biyokimya Dergisi, 34(4), 250 - 255.
Chicago SÖZMEN Eser Y.,Kayikcioglu Meral,SEZER Ebru,İLANBEY BİLAL,AKÇAY Yasemin D.,KULTURSAY HAKAN PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. Türk Biyokimya Dergisi 34, no.4 (2009): 250 - 255.
MLA SÖZMEN Eser Y.,Kayikcioglu Meral,SEZER Ebru,İLANBEY BİLAL,AKÇAY Yasemin D.,KULTURSAY HAKAN PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. Türk Biyokimya Dergisi, vol.34, no.4, 2009, ss.250 - 255.
AMA SÖZMEN E,Kayikcioglu M,SEZER E,İLANBEY B,AKÇAY Y,KULTURSAY H PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. Türk Biyokimya Dergisi. 2009; 34(4): 250 - 255.
Vancouver SÖZMEN E,Kayikcioglu M,SEZER E,İLANBEY B,AKÇAY Y,KULTURSAY H PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population. Türk Biyokimya Dergisi. 2009; 34(4): 250 - 255.
IEEE SÖZMEN E,Kayikcioglu M,SEZER E,İLANBEY B,AKÇAY Y,KULTURSAY H "PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population." Türk Biyokimya Dergisi, 34, ss.250 - 255, 2009.
ISNAD SÖZMEN, Eser Y. vd. "PON192 polymorphism and LDL-oxidation as risk factors for coronary artery disease in young Turkish population". Türk Biyokimya Dergisi 34/4 (2009), 250-255.
Sayfa Oluşturulma Tarihi
22-04-2024 14:40

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