Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population

SİPAHİ, Oğuz Reşat; PULLUKÇU, Hüsnü; TAŞBAKAN, Işıkgöz Meltem; ÇALIK, Özkören Şebnem; SERTÖZ, Önen Özen; YAMAZHAN, Tansu

Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population

Işıkgöz Meltem TAŞBAKAN, (Ege Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları Anabilim Dalı, İzmir, Türkiye)

Önen Özen SERTÖZ, (Ege Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, İzmir, Türkiye)

Hüsnü PULLUKÇU, (Ege Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları Anabilim Dalı, İzmir, Türkiye)

Özkören Şebnem ÇALIK, (Ege Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları Anabilim Dalı, İzmir, Türkiye)

Oğuz Reşat SİPAHİ, (Ege Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları Anabilim Dalı, İzmir, Türkiye)

Tansu YAMAZHAN (Ege Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları Anabilim Dalı, İzmir, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2010 Cilt: 40 Sayı: 4 Sayfa Aralığı: 575 - 583 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population

Öz:

Amaç: Bu çalışmada, kliniğimizde ayaktan takip edilen inaktif hepatit B (HBV) enfeksiyonu olan hastalar ile kronik hepatit B hastaları ve normal populasyonun yaşam kalitelerinin karşılaştırılması amaçlanmıştır. Yöntem ve gereç: Çalışmaya alınacak hastalar iki gruba ayrılmıştır. İlk grubu Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji kliniğine düzenli olarak gelen ve ayaktan takip edilen inaktif HBV hastaları oluşturmuştur. Kontrol grubunda ise, aynı dönemde kronik HBV enfeksiyonu tanısı konulmuş ve henüz tedavi görmeyen hastalar yer almıştır. Her iki grubun da yaş, cinsiyet ve eğitim derecesini sorgulayan bir anket formu ile yaşam kalitesini belirlemek üzere Kısa Form 36 (SF-36) yaşam kalitesi ölçeğini doldurmaları istenmiştir. Bu iki gruptan elde edilen sonuçlar aynı zamanda sağlıklı Türk populasyonunun yaşam kalitesi sonuçları ile karşılaştırılmıştır. Bulgular: İnaktif hepatit B enfeksiyonu olan hastalar fiziksel rol güçlüğü skoru dışında kronik HBV hastaları ile büyük oranda benzer bulunmuştur. Her iki grubun da yaşam kalitesi skorunun, normal Türk populasyonuna göre daha düşük olduğu saptanmıştır.Sonuç: Hem kronik HBV enfeksiyonu hem de inaktif HBV taşıyıcılarının yaşam kaliteleri normal populasyona göre olumsuz etkilenmektedir.

Anahtar Kelime:

Konular: Cerrahi

İnaktif hepatit B hastaları, kronik hepatit B hastaları ve sağlıklı populasyonunun yaşam kalitelerinin karşılaştırılması

Öz:

Aim: To compare health related quality of life (HRQOL) in hepatitis B virus (HBV) carriers versus chronic HBV disease carriers versus the normal population.Materials and methods: The study sample consisted of 2 groups. HBV carriers were recruited from individuals who were regularly followed-up at the Infectious Diseases and Clinical Microbiology outpatient clinic of our setting due to inactivity in HBV infection. The control group was recruited from the same outpatient clinic among patients who had a diagnosis of chronic HBV infection and who were not undergoing active treatment yet. Both groups were requested to fill in the short form 36 questionnaire on HRQOL (HRQOL-SF-36) and a form to gather data about age, gender, and education. We also compared the mean values of the SF-36 domain scores of these 2 groups with published scores of healthy controls derived from the Turkish population.Results: QOL in HBV carriers was greatly similar to that of patients with chronic HBV disease except for physical role limitation scores and both HBV carriers and patients with chronic disease had lower HRQOL than the normal Turkish population.Conclusion: When compared with the normal Turkish population, QOL is affected negatively both in chronic HBV infection patients and in HBV carriers.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Curry MP, Chopra S. Acute Viral Hepatitis. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of Infectious Diseases. 6th ed. Philadelphia: Churchill Livingstone; 2005. p. 1426-1441.
2. Taşyaran MA. Epidemiology of hepatitis B virus infection. In: Kılıçturgay K, Badur S, editors. Viral Hepatit 2001. İstanbul; 2000. p. 121-129 (Turkish).
3. Pojoga C, Dumitrascu DL, Pascu O, Grigorescu M, Radu C, Damian D. Impaired health-related quality of life in Romanian patients with chronic viral hepatitis before antiviral therapy. Eur J Gastroenterol Hepatol 2004; 16: 27-31.
4. Younossi ZM, Boparai N, Price LL, Kiwi ML, McCormick M, Guyatt G. Health-related quality of life in chronic liver disease: the impact of type and severity of disease. Am J Gastroenterol 2001; 96: 2199-205.
5. Ware JE, Bayliss MS, Mannocchia M, Davis GL, International Hepatitis Therapy Group. Health-related quality of life in chronic hepatitis C: impact of disease and treatment response. Hepatology 1999; 30: 550-5.
6. Park CK, Park SY, Kim ES, Park JH, Hyun DW, Yun YM et al. Assessment of quality of life and associated factors in patients with chronic viral liver disease. Taehan Kan Hakhoe Chi 2003; 9: 212-21.
7. Ateşçi FC, Çetin BC, Oğuzhanoğlu NK, Karadağ F, Turgut H. Psychiatric disorders and functioning in hepatitis B virus carriers. Psychosomatics 2005; 46: 142-7.
8. Kunkel EJS, Kim JS, Hann HW, Oyesanmi O, Menefee LA, Field HL et al. Depression in Korean immigrants with hepatitis B and related liver diseases. Psychosomatics 2000; 41: 472-80.
9. Testa M, Simonson D. Assessment of quality of life outcomes. N Engl J Med 1996; 334: 835-40.
10. Niederau C, Fischer C, Kautz A. Socio-economical aspects, quality of life and state of knowledge in hepatitis B patients. Soci-economical aspects in hepatitis B. Z Gastroenterol 2007; 45: 355-68.
11. Younossi ZM, Guyatt G. Quality of life assessments in chronic liver disease. Am J Gastroenterol 1998; 93: 1037-41.
12. Foster GR, Goldin RD, Thomas HC. Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology 1998; 27: 209-12.
13. Tarlov AR, Ware JE Jr, Greenfield S, Nelson EC, Perrin E, Zubkoff M. The Medical Outcomes Study. An application of methods for monitoring the results of medical care. JAMA 1989; 262: 925-30.
14. Ware JE JR, Sherbourne CD. The MOS 36- item short form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992; 30: 473-83.
15. Bonkovsky HL, Woolley JM. Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy. The Consensus Interferon Study Group. Hepatology 1999; 29:264-70.
16. Iwasaki M, Kanda D, Toyoda M, Yuasa K, Hashimoto Y, Takagi H et al. Absence of specific symptoms in chronic hepatitis C. J Gastroenterol 2002; 37: 709-16.
17. Yi LX, Yang X, Wang XW. Effect of Lamivudine treatment on the quality of life of chronic hepatitis B. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2006; 31: 396-9.
18. Lok ASF, McMahon BJ. AASLD practise guidelines: chronic hepatitis B: update of recommendations. Hepatology 2004; 39:1-5.
19. Keeffe EB, Dieterich DT, Han SH, Jacobson IM, Martin P, Schiff ER et al. A treatment algorithm for the management of chronic hepatitis B virus infection in the United States. Clin Gastroenterol Hepatol 2004; 2: 87-106.
20. Demiral Y, Ergör G, Ünal B, Semin S, Akvardar Y, Kıvırcık B et al. Normative data and discriminative properties of short form 36 (SF-36) in Turkish urban population. BMC Public Health. 2006; 6: 247-54
21. Koçyiğit H, Aydemir O, Ölmez N, Memiş A. Kisa Form-36’nin Türkçe Versiyonunun Güvenirliği ve Geçerliliği. İlaç ve Tedavi Dergisi 1999; 12: 102-6.
22. Sharif F, Mohebbi S, Tabatabaee HR, Firoozi MS, Gholamzadeh S. Effects of psycho-educational intervention on health-related quality of life (QOL) of patients with chronic liver disease referring to Shiraz University of Medical Sciences. Health Qual Life Outcomes 2005; 3: 81.
23. Balcıoğlu I, Özdemir S. Neuropsychiatric symptoms associated with chronic hepatitis. In: Viral Hepatit 2005. Tabak F, Balık I, Tekeli E, editors. İstanbul: Ohan Matbaası, 2005. p. 76-82.
24. Caylan R. Chronic Hepatitis and quality life. In: Viral Hepatit 2007. Tabak F, Balık I, Tekeli E, editors. İstanbul: Ohan Matbaası, 2006. p. 376-82.
25. Özkan M, Çorapçıoğlu A, Balcıoğlu I, Ertekin E, Khan S, Özdemir S et al. Psychiatric morbidity and its effect on the quality of life of patients with chronic hepatitis B and hepatitis C. Int J Psychiatry Med 2006; 36: 283-97.
26. Hussain KB, Fontana RJ, Moyer CA, Su GL, Sneed-Pee N, Lok AS. Comorbid illness is an important determinant of health- related quality of life in patients with chronic hepatitis C. Am J Gastroenterol 2001; 96: 2734-44.
27. Bao ZJ, Qiu DK, Ma X, Fan ZP, Zhang GS, Huang YQ, Yu XF, Zeng MD. Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy. World J Gastroenterol 2007; 13: 3003-8.
28. Pınar R. Reliability and construct validity of the SF-36 in Turkish cancer patients. Qual Life Res 2005; 14: 259-64.
29. Bayliss MS, Gandek B, Bungay KM, Sugano D, Hsu MA, Ware JE Jr. A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C. Qual Life Res 1998; 7: 39-55.
30. Wu GC, Zhou WP, Zhao YR, Guo SH, Wang ZY, Zou SB et al. Long-term health-related quality of life in chronic hepatitis B patients. Zhonghua Gan Zang Bing Za Zhi 2003; 11: 275-7.

APA	TAŞBAKAN I, SERTÖZ Ö, PULLUKÇU H, ÇALIK Ö, SİPAHİ O, YAMAZHAN T (2010). Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. , 575 - 583.
Chicago	TAŞBAKAN Işıkgöz Meltem,SERTÖZ Önen Özen,PULLUKÇU Hüsnü,ÇALIK Özkören Şebnem,SİPAHİ Oğuz Reşat,YAMAZHAN Tansu Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. (2010): 575 - 583.
MLA	TAŞBAKAN Işıkgöz Meltem,SERTÖZ Önen Özen,PULLUKÇU Hüsnü,ÇALIK Özkören Şebnem,SİPAHİ Oğuz Reşat,YAMAZHAN Tansu Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. , 2010, ss.575 - 583.
AMA	TAŞBAKAN I,SERTÖZ Ö,PULLUKÇU H,ÇALIK Ö,SİPAHİ O,YAMAZHAN T Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. . 2010; 575 - 583.
Vancouver	TAŞBAKAN I,SERTÖZ Ö,PULLUKÇU H,ÇALIK Ö,SİPAHİ O,YAMAZHAN T Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. . 2010; 575 - 583.
IEEE	TAŞBAKAN I,SERTÖZ Ö,PULLUKÇU H,ÇALIK Ö,SİPAHİ O,YAMAZHAN T "Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population." , ss.575 - 583, 2010.
ISNAD	TAŞBAKAN, Işıkgöz Meltem vd. "Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population". (2010), 575-583.

APA	TAŞBAKAN I, SERTÖZ Ö, PULLUKÇU H, ÇALIK Ö, SİPAHİ O, YAMAZHAN T (2010). Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. Turkish Journal of Medical Sciences, 40(4), 575 - 583.
Chicago	TAŞBAKAN Işıkgöz Meltem,SERTÖZ Önen Özen,PULLUKÇU Hüsnü,ÇALIK Özkören Şebnem,SİPAHİ Oğuz Reşat,YAMAZHAN Tansu Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. Turkish Journal of Medical Sciences 40, no.4 (2010): 575 - 583.
MLA	TAŞBAKAN Işıkgöz Meltem,SERTÖZ Önen Özen,PULLUKÇU Hüsnü,ÇALIK Özkören Şebnem,SİPAHİ Oğuz Reşat,YAMAZHAN Tansu Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. Turkish Journal of Medical Sciences, vol.40, no.4, 2010, ss.575 - 583.
AMA	TAŞBAKAN I,SERTÖZ Ö,PULLUKÇU H,ÇALIK Ö,SİPAHİ O,YAMAZHAN T Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. Turkish Journal of Medical Sciences. 2010; 40(4): 575 - 583.
Vancouver	TAŞBAKAN I,SERTÖZ Ö,PULLUKÇU H,ÇALIK Ö,SİPAHİ O,YAMAZHAN T Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population. Turkish Journal of Medical Sciences. 2010; 40(4): 575 - 583.
IEEE	TAŞBAKAN I,SERTÖZ Ö,PULLUKÇU H,ÇALIK Ö,SİPAHİ O,YAMAZHAN T "Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population." Turkish Journal of Medical Sciences, 40, ss.575 - 583, 2010.
ISNAD	TAŞBAKAN, Işıkgöz Meltem vd. "Comparison of quality of life in hepatitis B virus carriers versus chronic hepatitis B virus carriers versus the normal population". Turkish Journal of Medical Sciences 40/4 (2010), 575-583.