The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats

Arzuhan ÇETİNDAĞ ÇİLTAŞ, (Sivas Cumhuriyet Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbı Hizmetler ve Teknikler Bölümü, Sivas, Türkiye)
Ayşegül ÖZTÜRK (Sivas Cumhuriyet Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbı Hizmetler ve Teknikler Bölümü, Sivas, Türkiye)
Türk Doğa ve Fen Dergisi
3 1
Yıl: 2022 Cilt: 11 Sayı: 1 Sayfa Aralığı: 6 - 10 Metin Dili: İngilizce DOI: 10.46810/tdfd.882078 İndeks Tarihi: 06-01-2023

The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats

Öz:
Epilepsyisadiseasewhichcausesneuronaldamageandlossofconsciousnessin consequence of recurrent seizures. Nitric oxide as a neuromodulator in brain is a gas which can penetrate into cells. It has a significant role on physiological cases,pathology of many diseases suchasinflammationanddegenerativediseases.Thepurposeofthisresearchistosearchthe activity of NO/cGMP pathway of valproic acid in an experimental acuteepileptic model which is induced with pentylenetetrazol in rats.18 adult male Wistar Albino rats were used in the study. Theratswererandomlydividedinto3groups(n=6)ascontrolgroup,pentylenetetrazol (PTZ+salin)45mgkg-1,valproicacid(PTZ+VPA)150mgkg-1.After24hoursofPTZ application, all rats brain tissues were removed and then cortex and hippocampus were separated. WhilePTZincreasedthehippocampusandcortexNO/cGMPlevelscomparedtocontrol(p <0.01),VPAdecreasedthehippocampusandcortexNOlevelsbycomparisonwithPTZ(p <0.001). On the other hand, while VPA decreased cortex cGMP levels (p<0,05) it did not change cGMP levels in hippocampus (p> 0.05). This study has suggested that VPA can show antiepileptic activity via NO/cGMP pathway.
Anahtar Kelime: Valproin Acid NO/cGMP Pentylenetetrazole Epilepsy

Sıçanlarda Pentilentetrazol ile İndüklenen Akut Epilepsi Modelinde Valproik Asidin NO/cGMP Üzerindeki Etkileri

Öz:
Epilepsi, tekrarlayan nöbetlerle nöronal hasara, bilinç kaybına neden olan bir hastalıktır. Nitrik oksit (NO); beyinde nöromodülatör olarak ve hücreler arasında yayılabilen bir gazdır. Fizyolojik olaylarda, iltihaplanma ve dejeneratif hastalıklar gibi birçok hastalığın patolojisinde önemli rolü vardır. Bu araştırmanın amacı, sıçanlarda pentilentetrazol ile indüklenen deneysel akut epileptik modelde valproik asidin NO/cGMP yolağının aktivitesini araştırmaktır.Çalışmada 18adetyetişkinerkekWistarAlbinosıçankullanıldı.Sıçanlarrastgelekontrolgrubu,pentilentetrazol (PTZ) 45 mg kg-1, valproik asit (VPA) 150 mg kg-1 olarak 3 gruba (n=6) ayrıldı. PTZuygulamasından24saatsonratümsıçanlarınbeyindokularıçıkarıldı,korteksve hipokampus ayrıldı.PTZ hipokamp ve korteks NO/cGMP düzeylerini kontrole göre artırırken (p <0,01), VPA hipokamp ve korteks NO düzeylerini PTZ'ye göre düşürdü (p<0,001). Ancak VPA korteks cGMP düzeylerini düşürürken (p <0,05), hipokampus cGMP düzeylerini değiştirmedi (p> 0,05).Buçalışma,VPA'nınantiepileptikaktivitesiniNO/cGMPyoluilegösterebileceğini düşündürmektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ÇETINDAG CİLTAS A, öztürk a (2022). The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. , 6 - 10. 10.46810/tdfd.882078
Chicago ÇETINDAG CİLTAS ARZUHAN,öztürk ayşegül The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. (2022): 6 - 10. 10.46810/tdfd.882078
MLA ÇETINDAG CİLTAS ARZUHAN,öztürk ayşegül The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. , 2022, ss.6 - 10. 10.46810/tdfd.882078
AMA ÇETINDAG CİLTAS A,öztürk a The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. . 2022; 6 - 10. 10.46810/tdfd.882078
Vancouver ÇETINDAG CİLTAS A,öztürk a The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. . 2022; 6 - 10. 10.46810/tdfd.882078
IEEE ÇETINDAG CİLTAS A,öztürk a "The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats." , ss.6 - 10, 2022. 10.46810/tdfd.882078
ISNAD ÇETINDAG CİLTAS, ARZUHAN - öztürk, ayşegül. "The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats". (2022), 6-10. https://doi.org/10.46810/tdfd.882078
APA ÇETINDAG CİLTAS A, öztürk a (2022). The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. Türk Doğa ve Fen Dergisi, 11(1), 6 - 10. 10.46810/tdfd.882078
Chicago ÇETINDAG CİLTAS ARZUHAN,öztürk ayşegül The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. Türk Doğa ve Fen Dergisi 11, no.1 (2022): 6 - 10. 10.46810/tdfd.882078
MLA ÇETINDAG CİLTAS ARZUHAN,öztürk ayşegül The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. Türk Doğa ve Fen Dergisi, vol.11, no.1, 2022, ss.6 - 10. 10.46810/tdfd.882078
AMA ÇETINDAG CİLTAS A,öztürk a The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. Türk Doğa ve Fen Dergisi. 2022; 11(1): 6 - 10. 10.46810/tdfd.882078
Vancouver ÇETINDAG CİLTAS A,öztürk a The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats. Türk Doğa ve Fen Dergisi. 2022; 11(1): 6 - 10. 10.46810/tdfd.882078
IEEE ÇETINDAG CİLTAS A,öztürk a "The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats." Türk Doğa ve Fen Dergisi, 11, ss.6 - 10, 2022. 10.46810/tdfd.882078
ISNAD ÇETINDAG CİLTAS, ARZUHAN - öztürk, ayşegül. "The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats". Türk Doğa ve Fen Dergisi 11/1 (2022), 6-10. https://doi.org/10.46810/tdfd.882078
Sayfa Oluşturulma Tarihi
24-04-2024 2:4

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