Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism

Mentese, Ahmet; Turedi, Suleyman; GÜNDÜZ, Abdülkadir; KARAHAN, Süleyman Caner; Öztuna, Funda; TOPBAS, MURAT; KOŞUCU, POLAT; Tatli, Ozgur

Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism

Süleyman TÜREDİ, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Trabzon, Türkiye)

Süleyman Caner KARAHAN, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Trabzon, Türkiye)

Ahmet MENTEŞE, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Trabzon, Türkiye)

Abdülkadir GÜNDÜZ, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Trabzon, Türkiye)

Murat TOPBAŞ, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Trabzon, Türkiye)

Polat KOŞUCU, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Trabzon, Türkiye)

Funda ÖZTUNA, (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Trabzon, Türkiye)

Özgür TATLI (Karadeniz Teknik Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Trabzon, Türkiye)

Anadolu Kardiyoloji Dergisi

4 1

Yıl: 2010 Cilt: 10 Sayı: 4 Sayfa Aralığı: 346 - 352 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism

Öz:

İki farklı radyolojik parametre, pulmoner arter obstrüksiyon indeksi (PAOI) ve sağ ventrikül/sol ventrikül oranı (RV/LV) temel alınarak, radyolojik görüntüleme-esaslı pulmoner embolizm şiddet skoru ile D- dimer ve iskemi modifiye albümin (IMA) düzeyleri arasındaki muhtemel ilişkiyi incelemek. Yöntemler: Bu prospektif kohort çalışmasında, acil servise başvuran ve spiral bilgisayarlı tomografi (CT) ile PE kesin tanısı konulan kırk yedi hasta çalışmaya dahil edildi. D-dimer ve IMA düzeyleri sırasıyla immuno-turbidimetrik ve kolorimetrik metodlarla belirlendi. Bilgisayarlı tomografi görüntülerinden PAOI ve RV/LV oranları hesaplandı. Biyokimyasal parametrelerin gruplar arasındaki seviyeleri Mann-Whitney U test ve Kruskal-Wallis test kullanılarak karşılaştırıldı ve radyolojik skorlar ile ilişkileri Spearman korelasyon testi kullanılarak belirlendi. Bulgular: Hesaplanan PAOI ve RV/LV oranlarının analizi aralarında belirgin bir ilişki olduğunu yansıttı (r=0.036, p=0.023). PAOI temelinde oluşturulan hafif (< %40), orta (%40 - %60) ve şiddetli (> %60) PE grupları arasında D-dimer düzeyleri göze çarpan oranda farklıydı (p=0.039). Bu fark hafif grup, PAOI< %40, ile şiddetli grup, PAOI> %60 arasındaki D-dimer seviyelerindeki farklılıktan kaynaklanıyordu (p=0.02; Z= -2.328). Aynı zamanda, D-dimer düzeyleri ile PAOI pozitif bir korelasyon gösteriyordu, fakat D-dimer düzeyleri ile RV/LV oranı arasında benzer bir korelasyon yoktu. İskemi modifiye albümin düzeyleri ile D-dimer düzeyleri, PAOI ve RV/LV oranı arasında anlamlı bir korelasyon yoktu.Sonuç: Radyolojik parametreler temelinde PE’nin şiddetinin biyokimyasal olarak belirlenmesinde D-dimer, yeni bir marker olarak önerilen IMA’ya göre daha uygun bir marker olabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Akut pulmoner embolizmde D-dimer ve iskemi modifiye albümin değerleri ile radyolojik görüntüleme-esaslı pulmoner embolizm şiddet skoru arasındaki ilişkinin incelenmesi

Öz:

To investigate possible relationship between the D-dimer and ischemia-modified albumin (IMA) levels and radiological imaging-based severity scores in pulmonary embolism (PE) based on two different radiological characteristics; the pulmonary arterial obstruction index (PAOI) and the right ventricle/left ventricle (RV/LV) ratio. Methods: In this prospective cohort study, forty-seven patients presenting to the emergency department and definitively diagnosed with PE using spiral computerized tomography (CT) were initially enrolled in the study. Levels of IMA and D-dimer were assessed colorimetrical and immuno-turbidimetric methods, respectively. The PAOI and RV/LV ratios were calculated from CT images. The levels of biochemical parameters between the groups were compared with use of Mann-Whitney U and Kruskal-Wallis tests and relationship between the radiological scores were assessed using the Spearman correlation test. Results: Analysis of the calculated PAOI and RV/LV ratio revealed a significant correlation between them (r=0.36, p=0.023). D-dimer levels differed considerably among the mild (<40%), moderate (40%-60%) and severe (60%) groups constituted on the basis of PAOI (p=0.039). This difference stemmed from those in D-dimer levels in the mild group, PAOI <40% and the severe group, PAOI 60% (p=0.02; Z= -2.328). In addition, D-dimer levels and PAOI revealed a positive correlation, but no similar correlation was determined between D-dimer levels and RV/LV. There were no significant correlations between IMA and D-dimer levels, PAOI and RV/LV ratios. Conclusion: In the biochemical determination of severity of PE based on radiological characteristics, D-dimer may be a more relevant marker than IMA, which has been proposed as a new marker.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Turedi S, KARAHAN S, Mentese A, GÜNDÜZ A, TOPBAS M, KOŞUCU P, Öztuna F, Tatli O (2010). Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. , 346 - 352.
Chicago	Turedi Suleyman,KARAHAN Süleyman Caner,Mentese Ahmet,GÜNDÜZ Abdülkadir,TOPBAS MURAT,KOŞUCU POLAT,Öztuna Funda,Tatli Ozgur Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. (2010): 346 - 352.
MLA	Turedi Suleyman,KARAHAN Süleyman Caner,Mentese Ahmet,GÜNDÜZ Abdülkadir,TOPBAS MURAT,KOŞUCU POLAT,Öztuna Funda,Tatli Ozgur Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. , 2010, ss.346 - 352.
AMA	Turedi S,KARAHAN S,Mentese A,GÜNDÜZ A,TOPBAS M,KOŞUCU P,Öztuna F,Tatli O Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. . 2010; 346 - 352.
Vancouver	Turedi S,KARAHAN S,Mentese A,GÜNDÜZ A,TOPBAS M,KOŞUCU P,Öztuna F,Tatli O Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. . 2010; 346 - 352.
IEEE	Turedi S,KARAHAN S,Mentese A,GÜNDÜZ A,TOPBAS M,KOŞUCU P,Öztuna F,Tatli O "Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism." , ss.346 - 352, 2010.
ISNAD	Turedi, Suleyman vd. "Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism". (2010), 346-352.

APA	Turedi S, KARAHAN S, Mentese A, GÜNDÜZ A, TOPBAS M, KOŞUCU P, Öztuna F, Tatli O (2010). Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. Anadolu Kardiyoloji Dergisi, 10(4), 346 - 352.
Chicago	Turedi Suleyman,KARAHAN Süleyman Caner,Mentese Ahmet,GÜNDÜZ Abdülkadir,TOPBAS MURAT,KOŞUCU POLAT,Öztuna Funda,Tatli Ozgur Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. Anadolu Kardiyoloji Dergisi 10, no.4 (2010): 346 - 352.
MLA	Turedi Suleyman,KARAHAN Süleyman Caner,Mentese Ahmet,GÜNDÜZ Abdülkadir,TOPBAS MURAT,KOŞUCU POLAT,Öztuna Funda,Tatli Ozgur Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. Anadolu Kardiyoloji Dergisi, vol.10, no.4, 2010, ss.346 - 352.
AMA	Turedi S,KARAHAN S,Mentese A,GÜNDÜZ A,TOPBAS M,KOŞUCU P,Öztuna F,Tatli O Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. Anadolu Kardiyoloji Dergisi. 2010; 10(4): 346 - 352.
Vancouver	Turedi S,KARAHAN S,Mentese A,GÜNDÜZ A,TOPBAS M,KOŞUCU P,Öztuna F,Tatli O Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism. Anadolu Kardiyoloji Dergisi. 2010; 10(4): 346 - 352.
IEEE	Turedi S,KARAHAN S,Mentese A,GÜNDÜZ A,TOPBAS M,KOŞUCU P,Öztuna F,Tatli O "Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism." Anadolu Kardiyoloji Dergisi, 10, ss.346 - 352, 2010.
ISNAD	Turedi, Suleyman vd. "Investigation of relationship between the D-dimer and ischemia-modified albumin levels with the radiological imaging-based pulmonary embolism severity score in acute pulmonary embolism". Anadolu Kardiyoloji Dergisi 10/4 (2010), 346-352.