The current study aims to analyze the effect of real GDP, fixed capital, final consumption expenditures of the government, inflation rate, and current account balance formations on domestic savings within the scope of the annual data of MIST (Indonesia, South Korea, Mexico and Turkey) countries for the period of 1990-2019 by using the balanced panel data method. The cross-sectional dependence of the panel units used in the analysis was investigated using Pesaran (2015) CD test, and it was determined that the series had a weak inter-unit correlation. Therefore, Levin et al. (2002) (LLC) test, which is one of the first generation panel unit root tests, was used for the stationarity analysis of the analysis variables, and it was concluded that savings, GDP, inflation and current account balance series were stationary at the I(0) level while the public expenditure serieswere stationary at the I(I) level. The fixed effect panel regression analysis applied for the model created in this context was estimated using the Driscoll & Kraay (1998) estimator. As a result of the analysis, it has been determined the share of domestic savings that is positively affected in GDP from economic growth, fixed capital formations and current account balance; it is negatively affected from inflation and government expenditures. According to the findings, it is noteworthy that the variable with the most impact on domestic savings is the current account balance, while the variable with the least impact is growth. This result is an indication that domestic savings are closely related to the stability performance of countries regarding the external economic balance. As a matter of fact, the improvements in the current account balance will positively affect the domestic economic balance dynamics of the countries and contribute to the increase in savings. However, the low level of economic growth's impact on savings can be evaluated in the direction of giving priority to policies for external balance.