Tularemia is caused by Francisella tularensis which is capable of infecting various animals. Transmission to humans occurs most often through the bite of insects or contact with contaminated animal products. Tularemia may present different clinical forms such as ulceroglandular, glandular, oculoglandular, pulmonary and typhoidal. Oropharyngeal tularemia is the result of primary invasion through the oropharynx by contaminated food or water. Upon information that cervical nodes had developed in several people living in Ayaş-Yağmurdede Village, 16 cases with cervical nodes were detected in physical examination of the village inhabitants. It was learned that these cases had acute membraneous tonsillopharyngitis with high fever two months ago and following this period cervical nodes had developed in one or two weeks. Tube agglutination test using F. tularensis antigen was carried out and in 14 cases it was found positive at the titer of 1:256. The situation was thought as a waterborn outbreak. It was concluded that this region may be an endemic area for tularemia and should be observed for a long period.