Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri

Ramazan ÇÖL, (Selçuk Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Konya, Türkiye)
Zafer DURGUN (Selçuk Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Konya, Türkiye)
Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences
5 0
Yıl: 2004 Cilt: 20 Sayı: 1 Sayfa Aralığı: 29 - 38 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri

Öz:
Bu çalışma, tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon (DIC) üzerine E vitamini ve Prednisolon'un etkilerinin belirlenmesi amacıyla yapıldı. Hayvanlar üç eşit gruba ayrıldı. Endotoksemi, tüm gruplardaki hayvanlara 6 saat boyunca 100 |ig/kg/saat dozunda endotoksin (E. coli 0.111 :B4) infüzyonu ile oluşturuldu. Birinci grup kontrol (K) olarak kullanılırken ikinci grubu oluşturan hayvanlara (E) 4 gün 10 mg/kg/gün İP Vitamin E enjeksiyonu yapılarak son enjeksiyonu takiben 10. dakikadan itibaren endotoksin infüzyonuna başlandı. Üçüncü gruptaki (P) hayvanlara ise endotoksin in-füzyonundan 30 dakika önce 10mg/kg SK prednisolon verildi. Endotoksin infüzyonundan hemen önce (O.saat) ve infüzyonu izleyen 2., 4. ve 6. saatlerde kan örnekleri alındı. Çalışmada; endotoksin (K) grubunda APTT, PT ve TT de önemli derecede uzama, fibrinojen konsantrasyonu ve trombosit sayısında düşme, D-dimer seviyesinde yükselme ve lökopeni gözlenirken, akyuvar tipleri yüzdelerinde ise örnekleme zamanlarına göre anlamlı değişimler kaydedildi. Buna karşın; Vitamin E ve Prednisolon uygulamasının hemostatik ve hematolojik birçok parametrede meydana gelen olumsuz değişiklikleri önemli düzeyde baskıladığı belirlendi. Söz konusu etkinin E grubunkine göre P grubunda daha belirgin olduğu görüldü.
Anahtar Kelime: tavşan hematoloji akyuvarlar kan tablosu prednizolon E vitamini hemostaz plateletler lökopeni kan pıhtılaşması deneysel enfeksiyon Escherichia coli lipopolisakkarit ilaç tedavisi fibrinojen kan pıhtılaşma faktörleri yaygın damar içi pıhtılaşma endotoksinler

Konular: Veterinerlik

Effects of vitamin E and prednisolone on endotoxin-induced disseminated intravascular coagulation in rabbits

Öz:
This study was conducted to determine the protective effects of prednisolone and vitamin E on the development of endotoxin-induced disseminated intravascular coagulation (DIC) in rabbits. Experimental DIC was induced in all groups by intravenous infusion of 100 |ig/kg/h lipopolysaccharide (E coli 0111 :B4, LPS) for 6 h in 60 ml saline (10 ml/h). Vitamin E was injected (10 mg/kg,İP) for 4 successive days, and LPS was infused 10 min after the final vitamin E injection. Prednisolone was injected (10 mg/kg,SC) 30 min before the administration of LPS. Hemostatical and hematological markers at 0, 2,4, and 6 hr were determined. In this study, in the rabbits only receiving endotoxin we observed an important prolongation in APTT, PT and TT, and a decrease in platelet count and fibrinogen level, and an increase in D-dimer concentration, and leukophenia, and also significant changes in the percentage of differential leukocytes at sampling times. However, the administrations of prednisolone and vitamin E significantly caused the suppression on the determined parameters. We have suggested that the treatments of prednisolone and vitamin E may be useful in LPS-induced DIC, and we have concluded that prednisolone has more effective than vitamin E.
Anahtar Kelime: platelets leukopenia blood coagulation experimental infection Escherichia coli lipopolysaccharides drug therapy fibrinogen blood coagulation factors disseminated intravascular coagulation endotoxins rabbits haematology leukocytes blood picture prednisolone vitamin E haemostasis

Konular: Veterinerlik
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ÇÖL R, DURGUN Z (2004). Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. , 29 - 38.
Chicago ÇÖL Ramazan,DURGUN Zafer Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. (2004): 29 - 38.
MLA ÇÖL Ramazan,DURGUN Zafer Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. , 2004, ss.29 - 38.
AMA ÇÖL R,DURGUN Z Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. . 2004; 29 - 38.
Vancouver ÇÖL R,DURGUN Z Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. . 2004; 29 - 38.
IEEE ÇÖL R,DURGUN Z "Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri." , ss.29 - 38, 2004.
ISNAD ÇÖL, Ramazan - DURGUN, Zafer. "Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri". (2004), 29-38.
APA ÇÖL R, DURGUN Z (2004). Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, 20(1), 29 - 38.
Chicago ÇÖL Ramazan,DURGUN Zafer Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences 20, no.1 (2004): 29 - 38.
MLA ÇÖL Ramazan,DURGUN Zafer Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, vol.20, no.1, 2004, ss.29 - 38.
AMA ÇÖL R,DURGUN Z Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences. 2004; 20(1): 29 - 38.
Vancouver ÇÖL R,DURGUN Z Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences. 2004; 20(1): 29 - 38.
IEEE ÇÖL R,DURGUN Z "Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri." Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, 20, ss.29 - 38, 2004.
ISNAD ÇÖL, Ramazan - DURGUN, Zafer. "Tavşanlarda endotoksin ile oluşturulan dissemine intravasküler koagulasyon üzerine vitamin E ve prednisolon'un etkileri". Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences 20/1 (2004), 29-38.
Sayfa Oluşturulma Tarihi
22-04-2024 15:59

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