İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü

Küçük, Ayşegül; Bozok, Ümmü Gülşen; Arslan, Mustafa

doi:10.52827/hititmedj.1008303

İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü

Ümmü Gülşen BOZOK, (Kütahya Sağlık Bilimleri Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Kütahya, Türkiye)

Ayşegül KÜÇÜK, (Kütahya Sağlık Bilimleri Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Kütahya, Türkiye)

Mustafa ARSLAN (Gazi Üniversitesi, Tıp Fakültesi, Anestezi ve Reanimasyon Anabilim Dalı, Ankara, Türkiye)

Hitit medical journal (Online)

7 2

Yıl: 2022 Cilt: 4 Sayı: 2 Sayfa Aralığı: 64 - 73 Metin Dili: Türkçe DOI: 10.52827/hititmedj.1008303 İndeks Tarihi: 15-03-2023

İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü

Öz:

İskemi-reperfüzyon hasarı, miyokard enfarktüsü, iskemik inme, akut böbrek hasarı, periferik arter hastalığı, orak hücre anemisi dahil olmak üzere çok çeşitli patolojilerin morbidite ve mortalitesinde rol oynar. İskemide kan akımındaki azalmanın derecesine ve süresine bağlı olarak hücreler metabolik ihtiyaçlarını karşılayamaz. Hızlı reperfüzyon, oksijen açlığı çeken hücrelerin kurtarılması için gerekli olmasına rağmen, hücrede oluşan oksijen paradoksu hücreleri strese sürükler. Reperfüzyon ile birlikte ortaya çıkan stres yanıtı sınırlandırılamazsa hücre ölüm programları aktive olarak hücre ölür. Bu derlemenin amacı iskemi reperfüzyon hasarında rol oynayan hücresel stres mekanizmalarını ve ölüm programlarını tanımlamaktır.

Anahtar Kelime: Hücre ölüm yolları iskemi-reperfüzyon hasarı stres mekanizmaları

Stress and Cell Death in Ischemia Reperfusion Damage

Öz:

Ischemia-reperfusion injury is the most common cause of morbidity and mortality in some diseases, such as myocardial infarction, stroke, sickle cell anemia, and peripheral vascular disease. The degree of blood flow reduction and the length of the ischemic period are associated with metabolite starvation and tissue damage. Therefore, it is expected that reperfusion protects oxygen-starved tissues. However, producing reactive oxygen species with reperfusion (oxygen paradox) causes stress. If stress cannot be limited, cell death programs begin, and the cell dies. This review aims to describe cellular stress mechanisms and death programs that play a role in ischemia-reperfusion injury.

Anahtar Kelime: Apoptosis Autophagy İschemia-Reperfusion Injury Necrosis Stress Mechanisms

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Bozok Ü, Küçük A, Arslan M (2022). İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. , 64 - 73. 10.52827/hititmedj.1008303
Chicago	Bozok Ümmü Gülşen,Küçük Ayşegül,Arslan Mustafa İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. (2022): 64 - 73. 10.52827/hititmedj.1008303
MLA	Bozok Ümmü Gülşen,Küçük Ayşegül,Arslan Mustafa İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. , 2022, ss.64 - 73. 10.52827/hititmedj.1008303
AMA	Bozok Ü,Küçük A,Arslan M İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. . 2022; 64 - 73. 10.52827/hititmedj.1008303
Vancouver	Bozok Ü,Küçük A,Arslan M İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. . 2022; 64 - 73. 10.52827/hititmedj.1008303
IEEE	Bozok Ü,Küçük A,Arslan M "İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü." , ss.64 - 73, 2022. 10.52827/hititmedj.1008303
ISNAD	Bozok, Ümmü Gülşen vd. "İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü". (2022), 64-73. https://doi.org/10.52827/hititmedj.1008303

APA	Bozok Ü, Küçük A, Arslan M (2022). İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit medical journal (Online), 4(2), 64 - 73. 10.52827/hititmedj.1008303
Chicago	Bozok Ümmü Gülşen,Küçük Ayşegül,Arslan Mustafa İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit medical journal (Online) 4, no.2 (2022): 64 - 73. 10.52827/hititmedj.1008303
MLA	Bozok Ümmü Gülşen,Küçük Ayşegül,Arslan Mustafa İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit medical journal (Online), vol.4, no.2, 2022, ss.64 - 73. 10.52827/hititmedj.1008303
AMA	Bozok Ü,Küçük A,Arslan M İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit medical journal (Online). 2022; 4(2): 64 - 73. 10.52827/hititmedj.1008303
Vancouver	Bozok Ü,Küçük A,Arslan M İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü. Hitit medical journal (Online). 2022; 4(2): 64 - 73. 10.52827/hititmedj.1008303
IEEE	Bozok Ü,Küçük A,Arslan M "İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü." Hitit medical journal (Online), 4, ss.64 - 73, 2022. 10.52827/hititmedj.1008303
ISNAD	Bozok, Ümmü Gülşen vd. "İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü". Hitit medical journal (Online) 4/2 (2022), 64-73. https://doi.org/10.52827/hititmedj.1008303