Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi

cengil, osman; Turan, inci; SAYAN OZAÇMAK, HALE; Ozacmak, Veysel Haktan

doi:10.29058/mjwbs.2019.2.2

Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi

Osman Cengıl, (Zonguldak Bülent Ecevit Üniversitesi, Sağlık Bilimleri Enstitüsü, Fizyoloji Anabilim Dalı, Zonguldak, Türkiye)

Hale SAYAN ÖZAÇMAK, (Zonguldak Bülent Ecevit Üniversitesi, Tıp Fakültesi Fizyoloji Anabilim Dalı, Zonguldak, Türkiye)

İnci TURAN, (Zonguldak Bülent Ecevit Üniversitesi, Tıp Fakültesi Fizyoloji Anabilim Dalı, Zonguldak, Türkiye)

VEYSEL HAKTAN ÖZAÇMAK (Zonguldak Bülent Ecevit Üniversitesi, Tıp Fakültesi Fizyoloji Anabilim Dalı, Zonguldak, Türkiye)

Batı Karadeniz Tıp Dergisi

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Yıl: 2019 Cilt: 3 Sayı: 2 Sayfa Aralığı: 42 - 51 Metin Dili: Türkçe DOI: 10.29058/mjwbs.2019.2.2 İndeks Tarihi: 08-08-2022

Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi

Öz:

Amaç: Bu çalışma çevresel zenginleştirmenin (EE) kronik serebral hipoperfüzyonla (KSH) oluşturulan vasküler demans modelinde depresyon benzeri davranış, serebral korteks ve hipokampüsde beyin kaynaklı nörotrofik faktör (BDNF), kaspaz-1 ve IL-1β seviyeleri üzerine etkisini incelemek için tasarlanmıştır. Daha önceki çalışmalar EE’nin KSH modelinde oksidatif stres inhibisyonu ve endojen nörokoruyucu faktörlerin artırılmasını içeren yararlı etkilere sahip olduğunu göstermişlerdir. Gereç ve Yöntemler: KSH sıçanlarda bilateral ortak karotid arterlerin oklüzyonu ile oluşturulmuştur. Hayvanlar 3 gruba ayrılmıştır: Sham, standart kafes koşulları ve 4 hafta boyunca zenginleştirilmiş koşullara maruz bırakılan grup. Sükroz tercih testi ve zorlu yüzme testi (FST) KSH sonrası depresif davranışı değerlendirmek için kullanılmıştır. BDNF, IL-1β ve kaspaz-1 düzeylerindeki değişim incelenmiştir. Bulgular: KSH, hipokampüsde BDNF seviyesinde azalmaya, IL-1β ve kaspaz-1 düzeylerinde artış ile birlikte depresyon benzeri davranışa neden olmuştur.. Sonuç: EE serebral hipoperfüzyon durumunda inflamatuar yanıtı azaltarak ve BDNF seviyelerini koruyarak depresif davranışı iyileştirmede farmakolojik olmayan yeni bir strateji olabilir.

Anahtar Kelime: çevresel zenginleştirme vasküler demans BDNF depresif davranış

Effect Of Envıronmental Enrıchment On Depressıon-Lıke Behavıor, Cortıcal And Hıppocampal BDNF And IL-1 β In Vascular Dementıa Model

Öz:

Aim: This study was designed to investigate the effects of environmental enrichment (EE) on depressive like-behaviour, and cerebral cortex and hippocampus brain derived neurotrophic factor (BDNF), IL-1β and caspase-1 levels in vascular dementia model induced by chronic cerebral hypoperfusion (CCH). Previous studies demonstrated that EE posesses beneficial effects againts CCH including inhibition oxidative stress and stimulation of endogenous neuroprotective factors. Material and Methods: CCH was induced by permanent occlusion of the bilateral common carotid arteries in rats. Animals were divided into three groups: Sham control, standart cage condition and enriched condition for 4 weeks. Sucrose preference and forced swiming test (FST) were used for evaluation of depressive like behaviour after induction of CCH. The change in BDNF, IL-1β and caspase-1 levels were also examined. Results: CCH caused a decrease in the hippocampus BDNF level and depressive behaviour associated with increase in IL-1β and caspase-1 levels. EE attenuated depressive behaviour by preserving BDNF level and reducing inflammatory response in hippocampus. Conclusion: In conclusion, EE may be a new non-pharmacological strategy for ameliorating depressive like behaviour through reducing inflammatory response and restore BDNF levels in cerebral hypoperfusion condition.

Anahtar Kelime: environmental enrichment vascular dementia BDNF depressive like behaviour

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	cengil o, SAYAN OZAÇMAK H, Turan i, Ozacmak V (2019). Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. , 42 - 51. 10.29058/mjwbs.2019.2.2
Chicago	cengil osman,SAYAN OZAÇMAK HALE,Turan inci,Ozacmak Veysel Haktan Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. (2019): 42 - 51. 10.29058/mjwbs.2019.2.2
MLA	cengil osman,SAYAN OZAÇMAK HALE,Turan inci,Ozacmak Veysel Haktan Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. , 2019, ss.42 - 51. 10.29058/mjwbs.2019.2.2
AMA	cengil o,SAYAN OZAÇMAK H,Turan i,Ozacmak V Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. . 2019; 42 - 51. 10.29058/mjwbs.2019.2.2
Vancouver	cengil o,SAYAN OZAÇMAK H,Turan i,Ozacmak V Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. . 2019; 42 - 51. 10.29058/mjwbs.2019.2.2
IEEE	cengil o,SAYAN OZAÇMAK H,Turan i,Ozacmak V "Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi." , ss.42 - 51, 2019. 10.29058/mjwbs.2019.2.2
ISNAD	cengil, osman vd. "Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi". (2019), 42-51. https://doi.org/10.29058/mjwbs.2019.2.2

APA	cengil o, SAYAN OZAÇMAK H, Turan i, Ozacmak V (2019). Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi, 3(2), 42 - 51. 10.29058/mjwbs.2019.2.2
Chicago	cengil osman,SAYAN OZAÇMAK HALE,Turan inci,Ozacmak Veysel Haktan Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi 3, no.2 (2019): 42 - 51. 10.29058/mjwbs.2019.2.2
MLA	cengil osman,SAYAN OZAÇMAK HALE,Turan inci,Ozacmak Veysel Haktan Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi, vol.3, no.2, 2019, ss.42 - 51. 10.29058/mjwbs.2019.2.2
AMA	cengil o,SAYAN OZAÇMAK H,Turan i,Ozacmak V Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi. 2019; 3(2): 42 - 51. 10.29058/mjwbs.2019.2.2
Vancouver	cengil o,SAYAN OZAÇMAK H,Turan i,Ozacmak V Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi. Batı Karadeniz Tıp Dergisi. 2019; 3(2): 42 - 51. 10.29058/mjwbs.2019.2.2
IEEE	cengil o,SAYAN OZAÇMAK H,Turan i,Ozacmak V "Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi." Batı Karadeniz Tıp Dergisi, 3, ss.42 - 51, 2019. 10.29058/mjwbs.2019.2.2
ISNAD	cengil, osman vd. "Vasküler Demans Modelinde Çevresel Zenginleştirmenin Depresyon Benzeri Davranış, Kortikal ve Hipokampal BDNF ve IL-1β Seviyeleri Üzerine Etkisi". Batı Karadeniz Tıp Dergisi 3/2 (2019), 42-51. https://doi.org/10.29058/mjwbs.2019.2.2