Professional self-competence and self-efficacy of paramedics who first interfere to emergency events are important. An important ratio of deaths in emergency intervention are due to emergencies that require cardiopulmonary resuscitation (CPR), and also emergency labor is frequently seen in rural areas. In this research, CPR and labor simulation training’s effect on professional self-competence and relevance of self-efficacy in paramedic students has been investigated. The pre-test and post-test experimental research was carried out with 68 pregraduate paramedic students. Following the pre-questionnaire, all students were given simulation training about CPR and labor, and students were evaluated two times with a weak interval by making one-to-one simulation applications. Afterwards a post-questionnaire was applied, Sherer’s General Self-Efficacy Scale (SGSES) was used to determine self-efficacy levels. Professional self-competence perception level and evaluation scores of the students increased significantly in pre and post-questionnaire comparison. The statistically significant difference between professional self-competence perception and graduated high-school in pre-questionnaire was not obtained in post-questionnaire. While SGSES scores were higher in the students who felt more professional self-competence, SGSES scores and professional self-competence scores did not statistically differ among pre and post-questionnaires. Simulation trainings in the education process of paramedic students has significant impact on professional self-competence.