Yıl: 2022 Cilt: 12 Sayı: 2 Sayfa Aralığı: 107 - 115 Metin Dili: İngilizce DOI: 10.4274/buchd.galenos.2021.35762 İndeks Tarihi: 10-08-2022

Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder

Öz:
Objective: Epilepsy and electroencephalography (EEG) abnormalities are more commonly seen in autism spectrum disorder (ASD). The aim of the present study is determine the risk factors that cause epilepsy, seizures and EEG abnormalities in cases with EEG examination who were followed with the diagnosis of ASD. Method: A total of 166 cases diagnosed with ASD according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition in Dokuz Eylül University Faculty of Medicine Hospital Clinic of Child Psychiatry and whose neurological evaluations and examinations were performed in the pediatric neurology clinic, were included in the study. We retrospectively recorded and analyzed the cases’ clinical features, the results of physical examination, imaging and EEG, comorbidities and medications they used. Results: Of the cases, 74.4% were male. The mean age of cases with epilepsy diagnosis, at least one seizure and epileptic discharges on EEG was higher (p<0.001, p<0.001 and p=0.005, respectively). The history of epilepsy and having at least one seizure were more common in cases aged 11 years and older (p=0.001 and p=0.001, respectively). Abnormalities in EEG examination and epileptic discharges were detected to be more common in female ASD cases (p=0.041 and p=0.019 respectively). Conclusion: In ASD cases without any underlying chronic neurological disease, female gender is a risk factor for the development of EEG abnormality and epileptic discharges. Advanced age is a risk factor for seizures and development of epilepsy in ASD cases.
Anahtar Kelime:

Otistik Spektrum Bozukluğu olan Çocuk Olgularda Epilepsi ve Elektroensefalografi Anormallikleri

Öz:
Amaç: Otistik spektrum bozukluğunda (OSB) epilepsi ve elektroensefalografi (EEG) anormallikleri daha sık görülmektedir. Biz de kliniğimizde OSB ile izlenen ve EEG incelemesi olan olgularda epilepsi, nöbet ve EEG anormallikleri varlığına neden olan risk faktörlerini belirlemek istedik. Yöntem: Dokuz Eylül Üniversitesi Tıp Fakültesi Hastanesi Çocuk Psikiyatrisi kliniğinde Mental Bozuklukların Tanısal ve Sayımsal El Kitabı 5. Baskı’ya göre OSB tanısı almış ve çocuk nöroloji Kliniği'nde nörolojik değerlendirmesi ve EEG incelemesi yapılmış olan 166 OSB olgusunu çalışmaya dahil ettik. Retrospektif olarak olguların klinik özelliklerini, fizik muayene, görüntüleme, EEG bulgularını, eşlik eden hastalıklarını ve kullandıkları ilaçları kaydettik ve analiz ettik. Bulgular: Olgularımızın %74,6’sı erkekti. Epilepsi tanısı olan, en az bir epileptik nöbet geçiren ve EEG’de epileptik deşarjları olan olguların yaş ortalaması daha yüksekti (p<0,001, p<0,001 ve p=0,005, sırasıyla). On bir yaş ve daha büyük olgularda epilepsi ve en az bir nöbet geçirme öyküsü daha sıktı (p=0,001 ve p=0,001 sırasıyla). EEG’de anormallik ve epileptik deşarjlar kız OSB olgularında daha sık saptandı (p=0,041 ve p=0,019 sırasıyla). Sonuç: Altta başka bir kronik nörolojik hastalığı olmayan OSB olgularında kız cinsiyet EEG’de anormallik ve epileptik deşarjların gelişimi açısından bir risk faktörüdür. OSB olgularında ileri yaş, nöbet geçirme ve epilepsi gelişimi için bir risk faktörüdür.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA POLAT A, Hız A, yiş u, ayanoglu m, Okur D, bayram e, Baykara H (2022). Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. , 107 - 115. 10.4274/buchd.galenos.2021.35762
Chicago POLAT Ayşe İpek,Hız Ayşe Semra,yiş uluç,ayanoglu muge,Okur Derya,bayram erhan,Baykara Huseyin Burak Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. (2022): 107 - 115. 10.4274/buchd.galenos.2021.35762
MLA POLAT Ayşe İpek,Hız Ayşe Semra,yiş uluç,ayanoglu muge,Okur Derya,bayram erhan,Baykara Huseyin Burak Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. , 2022, ss.107 - 115. 10.4274/buchd.galenos.2021.35762
AMA POLAT A,Hız A,yiş u,ayanoglu m,Okur D,bayram e,Baykara H Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. . 2022; 107 - 115. 10.4274/buchd.galenos.2021.35762
Vancouver POLAT A,Hız A,yiş u,ayanoglu m,Okur D,bayram e,Baykara H Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. . 2022; 107 - 115. 10.4274/buchd.galenos.2021.35762
IEEE POLAT A,Hız A,yiş u,ayanoglu m,Okur D,bayram e,Baykara H "Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder." , ss.107 - 115, 2022. 10.4274/buchd.galenos.2021.35762
ISNAD POLAT, Ayşe İpek vd. "Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder". (2022), 107-115. https://doi.org/10.4274/buchd.galenos.2021.35762
APA POLAT A, Hız A, yiş u, ayanoglu m, Okur D, bayram e, Baykara H (2022). Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, 12(2), 107 - 115. 10.4274/buchd.galenos.2021.35762
Chicago POLAT Ayşe İpek,Hız Ayşe Semra,yiş uluç,ayanoglu muge,Okur Derya,bayram erhan,Baykara Huseyin Burak Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi 12, no.2 (2022): 107 - 115. 10.4274/buchd.galenos.2021.35762
MLA POLAT Ayşe İpek,Hız Ayşe Semra,yiş uluç,ayanoglu muge,Okur Derya,bayram erhan,Baykara Huseyin Burak Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, vol.12, no.2, 2022, ss.107 - 115. 10.4274/buchd.galenos.2021.35762
AMA POLAT A,Hız A,yiş u,ayanoglu m,Okur D,bayram e,Baykara H Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2022; 12(2): 107 - 115. 10.4274/buchd.galenos.2021.35762
Vancouver POLAT A,Hız A,yiş u,ayanoglu m,Okur D,bayram e,Baykara H Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2022; 12(2): 107 - 115. 10.4274/buchd.galenos.2021.35762
IEEE POLAT A,Hız A,yiş u,ayanoglu m,Okur D,bayram e,Baykara H "Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder." İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, 12, ss.107 - 115, 2022. 10.4274/buchd.galenos.2021.35762
ISNAD POLAT, Ayşe İpek vd. "Epilepsy and Electroencephalographic Abnormalities in Children with Autistic Spectrum Disorder". İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi 12/2 (2022), 107-115. https://doi.org/10.4274/buchd.galenos.2021.35762