Yıl: 2022 Cilt: 27 Sayı: 2 Sayfa Aralığı: 209 - 217 Metin Dili: İngilizce DOI: 10.5578/flora.20229804 İndeks Tarihi: 10-08-2022

An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures

Öz:
Introduction: Elizabethkingia meningoseptica is an emerging gram-negative opportunistic nosocomial pathogen reported in immunocompromised patients. We aimed to report an outbreak of E. meningoseptica acquisition in the intensive care units (ICUs) of a training and research hospital in Turkey and highlight the infection control measures. Materials and Methods: Bacterial strains were determined using MALDI Biotyper (Bruker Daltonics, Bremen, Germany) minimum inhibitor concentrations were examined using MicroScan automatized system. Results were determined according to the CLSI guidelines. Environmental cultures were obtained and investigated for the presence of E. meningoseptica. Clonal relationships among E. meningoseptica strains were investigated using PFGE. Results: Isolates were obtained from nine critically ill patients’ clinical samples. All strains were resistant to tested antibiotics (amikacin, Amox/Clav, cefepime, cefotaxime, ceftzidime, cefuroxime, ertapenem, gentamycin, meropenem, trimethoprim/sulfamethoxazole (TMP–SMX), imipenem) except for levofloxacin (8/9), ciprofloxacin (5/9), and piperacillin/tazobactam. PFGE indicated that the strains involved in the outbreak were closely related. Conclusion: Intrinsically multiple drug-resistant Elizabethkingia spp. isolates can be a common life-threatening pathogen in ICUs in our country, and prevention is possible through early notification of small-scale outbreaks and necessary infection control measures.
Anahtar Kelime:

Yoğun Bakım Ünitelerinde Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Salgını

Öz:
Giriş: Elizabethkingia meningoseptica bağışıklığı baskılanmış hastalarda artan oranda bildirilen Gram negatif fırsatçı hastane infeksiyonu etkenidir. Yoğun bakım ünitelerinden (YBÜ) izole edilen E. meningoseptica suşları arasındaki klonal ilişkiler ve bunların salgınla ilişkisi araştırıldı. Materyal ve Metod: İzolatlar MALDI-TOF kullanılarak tanımlandı (Bruker Dal-tonik GmbH, Bremen, Almanya). Antibiyotik Minimum inhibitör konsantrasyonları, MicroScan otomatize sistem kullanılarak belirlendi. Sonuçlar, Klinik ve Laboratuvar Standartları Enstitüsü kılavuzlarına göre raporlandı. Çevre kültürleri alındı ve E. meningoseptica varlığı açısından araştırıldı. E. meningoseptica suşları arasındaki klonal ilişkiler PFGE kullanılarak araştırıldı. Bulgular: İzolatlar anestezi yoğun bakım ünitesinden iki kadın (62 ve 82 yaşında), bir erkek (58 yaşında) ve koroner yoğun bakım ünitesinden iki kadın (73 ve 60 yaşında), iki erkek (57 ve 75 yaşında) ve dahiliye yoğun bakım ünitesinden iki kadın (65 ve 67 yaşında) hastanın klinik örneklerinden izole edildi. Suşlar levofloksasin (8/9), siprofloksasin (5/9) ve piperasilin/tazobaktam dışında test edilen antibiyotiklere dirençli bulundu. PFGE ile salgına dahil olan suşların yakından ilişkili olduğu gösterildi. Sonuç: Sonuç olarak, çoklu ilaç dirençli Elizabethkingia spp. izolatları ülkemizde yoğun bakım ünitelerinde tesbit edilen ve yaşamı tehdit eden bir patojendir. Salgından korunma küçük çaplı salgınların erken bildirilmesi ve gerekli infeksiyon kontrol önlemlerinin alınmasıyla mümkündür.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Erdem F, bozok t, kalaycı y, Meral Ocal M, Ünal N, KÖKSAL f (2022). An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. , 209 - 217. 10.5578/flora.20229804
Chicago Erdem Fatma,bozok taylan,kalaycı yıldız,Meral Ocal Melda,Ünal Nevzat,KÖKSAL fatih An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. (2022): 209 - 217. 10.5578/flora.20229804
MLA Erdem Fatma,bozok taylan,kalaycı yıldız,Meral Ocal Melda,Ünal Nevzat,KÖKSAL fatih An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. , 2022, ss.209 - 217. 10.5578/flora.20229804
AMA Erdem F,bozok t,kalaycı y,Meral Ocal M,Ünal N,KÖKSAL f An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. . 2022; 209 - 217. 10.5578/flora.20229804
Vancouver Erdem F,bozok t,kalaycı y,Meral Ocal M,Ünal N,KÖKSAL f An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. . 2022; 209 - 217. 10.5578/flora.20229804
IEEE Erdem F,bozok t,kalaycı y,Meral Ocal M,Ünal N,KÖKSAL f "An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures." , ss.209 - 217, 2022. 10.5578/flora.20229804
ISNAD Erdem, Fatma vd. "An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures". (2022), 209-217. https://doi.org/10.5578/flora.20229804
APA Erdem F, bozok t, kalaycı y, Meral Ocal M, Ünal N, KÖKSAL f (2022). An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 27(2), 209 - 217. 10.5578/flora.20229804
Chicago Erdem Fatma,bozok taylan,kalaycı yıldız,Meral Ocal Melda,Ünal Nevzat,KÖKSAL fatih An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 27, no.2 (2022): 209 - 217. 10.5578/flora.20229804
MLA Erdem Fatma,bozok taylan,kalaycı yıldız,Meral Ocal Melda,Ünal Nevzat,KÖKSAL fatih An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.27, no.2, 2022, ss.209 - 217. 10.5578/flora.20229804
AMA Erdem F,bozok t,kalaycı y,Meral Ocal M,Ünal N,KÖKSAL f An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2022; 27(2): 209 - 217. 10.5578/flora.20229804
Vancouver Erdem F,bozok t,kalaycı y,Meral Ocal M,Ünal N,KÖKSAL f An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2022; 27(2): 209 - 217. 10.5578/flora.20229804
IEEE Erdem F,bozok t,kalaycı y,Meral Ocal M,Ünal N,KÖKSAL f "An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 27, ss.209 - 217, 2022. 10.5578/flora.20229804
ISNAD Erdem, Fatma vd. "An Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) Outbreak in Intensive Care Units and Infection Control Measures". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 27/2 (2022), 209-217. https://doi.org/10.5578/flora.20229804