TY  - JOUR
TI  - Synthesis, characterization and biological activity evaluation of novel  thiazole derivatives containing acetic acid residue as selective COX-1  inhibitors
AB  - The fact that the side effect profiles of the COX inhibitors available in the market is very high  and most of these side effects are caused by non-selective inhibitors increases the need for new  selective COX-1 inhibitors. In this study, carried out to develop a new COX-1 inhibitor, the  thiazole ring system was preferred because of its known activity in the vary different field.  Additionally, The acid residue, which is in the structure of the most commonly used COX inhibitors such as ıbuprofen and flurbiprofen, was synthesized. 2-(4-((4-(Substituted  phenyl)thiazol-2-yl)amino)phenyl)acetic acid (3a-3c) series consisting of 3 new compounds  was synthesized. The structures of the obtained compounds were elucidated using 1H-NMR,  13C-NMR and mass spectroscopy data. The in vitro COX inhibitory activity of the compounds  was determined using fluorimetric methods.Among the synthesized compounds, the  compound 3c showed similar activity with the reference drug against the COX-1 enzyme.  When the selective COX-1 inhibitory potentials of the synthesized compounds are examined,  compound 3c comes to the fore. According to the results of this study, it is recommended to  investigate the selective COX-1 inhibitory activities of new compounds to be synthesized with  modifications to be made on the active derivative in the project.
AU  - OSMANİYE, DERYA
AU  - SAGLIK, BEGÜM NURPELIN
DO  - 10.17776/csj.968893
PY  - 2021
JO  - Cumhuriyet Science Journal
VL  - 42
IS  - 4
SN  - 2587-2680
SP  - 806
EP  - 813
DB  - TRDizin
UR  - http://search/yayin/detay/1110617
ER  -