TY  - JOUR
TI  - Electrochemical investigation of DNA and Capecitabine interaction using  glassy carbon electrode (GCE)
AB  - In recent years, studies with biosensors have increased in order to better understand the  mechanisms of anticancer drug action. Thus, studies to examine interactions with DNA using  biosensors have gained momentum. In our study, it was investigated that Capecitabine (CPT),  an anticancer drug, and glassy carbon electrode (GCE) interaction by using electrochemical  methods. The interaction of CPT with calf thymus DNAs (dsDNA, ssDNA) immobilized on  the electrode surface was analyzed by exploiting changes in the oxidation signals of the  guanine base. The immobilization of DNA on the electrode surface has been optimized.  Optimal DNA concentration and optimal interaction times were found. Electrochemical  impedance spectroscopy technique was used for impedimetric measurements. The results obtained confirmed that the ct-DNAs were immobilized on the electrode surface.  Detection limit (DL) was found as 17.54 μg / mL for interaction capecitabine with ds-DNA  and was found 17.12 μg / mL for interaction capecitabine with ss-DNA.
AU  - GÖKÇE, Gültekin
AU  - KIZILOLUK, Derya
AU  - Çetinus, Şenay
DO  - 10.17776/csj.953419
PY  - 2021
JO  - Cumhuriyet Science Journal
VL  - 42
IS  - 4
SN  - 2587-2680
SP  - 814
EP  - 821
DB  - TRDizin
UR  - http://search/yayin/detay/1110622
ER  -