TY  - JOUR
TI  - The Effects of Coriandrum sativum L. and Chaerophyllum macropodum Boiss. (Apiaceae) on human plasma angiotensin-converting enzyme (ACE) in vitro
AB  - Hypertension is a very important problem around the world. The inhibition of the Angiotensin-converting enzyme (ACE, EC.3.4.15.1.) is regarded as fundamental of hypertension treatment. However, synthetic ACE inhibitors have several side effects. For this reason, there are lots of studies to improve green ACE inhibitors. Therefore, this study was designed to determine the potential inhibitory effects of two members of Apiaceae, Coriandrum sativum and Chaerophyllum macropodum, on human plasma ACE. For this purpose, water extracts of the plants were used. ACE inhibition activity was detected spectrophotometrically. Both plant extracts showed an inhibitory effect on ACE activity. The obtained results showed that Coriandrum sativum and Chaerophyllum macropodum have inhibitory effects on human plasma ACE with an $IC_{50}$ value of 0.7 mg/mL and 1.14 mg/mL, respectively. Lineweaver-Burk graph was used to determine the inhibition type. The inhibition types were found as reversible noncompetitive. According to the obtained results, Coriandrum sativum and Chaerophyllum macropodum are valuable functional food with ACE inhibition capacity which may be used to balance blood pressure efficiently.
AU  - Çelikezen, Fatih Çağlar
AU  - BAŞ, Zehra
AU  - TÜRKOĞLU, Vedat
AU  - Fırat, Mehmet
PY  - 2021
JO  - Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
VL  - 10
IS  - 3
SN  - 2147-3129
SP  - 710
EP  - 718
DB  - TRDizin
UR  - http://search/yayin/detay/1111843
ER  -