TY  - JOUR
TI  - The Therapeutic Potency of Hesperis matronalis subsp. matronalis for Alzheimer's and Microbial Diseases
AB  - The goal of the present study, to investigate for the methanolic extract from the aerial parts of Hesperis matronalis subsp. matronalis in terms of acetylcholinesterase (AChE) and butyrylcholinesterase inhibitory and antimicrobial effects to detect therapeutic potential of Alzheimer's and microbial diseases. Alzheimer’s disease is a serious health problem  because of its memory defect effect related with neurodegenerative damage. Microorganisms are associated with many ailments that cause negative effects on human health. Hesperis genus is represented by 28 genus in Turkey. Hesperis matronalis subsp. matronalis was selected for the study among from the genus.  The inhibitory activities of AChE and BuChE of Hesperis matronalis subsp. matronalis were determined by colorimetric Ellman’s method and the antimicrobial activity was executed using agar diffusion method.  As a result of the study, the antimicrobial activity of Hesperis matronalis subsp. matronalis was observed on Escherichia coli, Yersinia pseudotuberculosis, Klebsiella pneumonia subp. Pneumonia, Staphylococcus aureus, Enterococcus faecalis, Mycobacterium smegmatis, Bacillus cereus and Candida albicans. The IC50 values for inhibitory activities of AChE and BuChE of Hesperis matronalis subsp. matronalis have been found as 316.23 ± 2.15 and 74.13 ± 0.85 µg mL-1, respectively. Because of significiant inhibitory effects on AChE and BuChE  and antimicrobial activity, Hesperis matronalis subsp. matronalis can be a candidate alternative natural drug source in the treatment of Alzheimer's and many microbial diseases.
AU  - Özgen, Ufuk
AU  - SENER, SILA OZLEM
AU  - Alpay Karaoğlu, Şengül
AU  - aliyazicioglu, rezzan
AU  - TERZİOĞLU, SALİH
AU  - KANBOLAT, Şeyda
AU  - Korkmaz, Nuriye
AU  - badem, merve
DO  - 10.22312/sdusbed.817540
PY  - 2021
JO  - Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi
VL  - 12
IS  - 1
SN  - 2146-247X
SP  - 38
EP  - 43
DB  - TRDizin
UR  - http://search/yayin/detay/1112237
ER  -