Yıl: 2022 Cilt: 5 Sayı: 2 Sayfa Aralığı: 122 - 129 Metin Dili: Türkçe DOI: 10.26650/JARHS2022-1122852 İndeks Tarihi: 18-08-2022

KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER

Öz:
Konvansiyonel ilaç salım sistemleri dar terapötik pencere, uzun dönem tedavilerdeki kompleks dozlama aralığı ve sistemik toksisite gibi kısıtlayıcı faktörlerle günümüzde pek çok alanda yetersiz kalabilmektedir. Buna istinaden, ilacın farmakolojik aktivitesini istenilen oranda, istenen bölgeye lokalize etmeyi amaçlayan ve daha çok ilaç için daha az komplikasyonla artırılmış aktivite sergileyen yeni kontrollü ilaç salım sistemleri arayışına gidilmiştir. Bu ihtiyaçları karşılamak üzere geliştirilen mikroakışkan bazlı ilaç salım sistemleri ile daha iyi hasta uyuncu sağlanabilmekte, gelişmiş ilaç uygulamaları ile daha iyi salım kontrollü oluşturulabilmektedir. Nano/ mikro boyuttaki sıvıların kontrolü ve manüplasyonu ile oluşturulan bu sistemler tek bir çip üzerinde eşsiz bir karakterle kontrollü salım platformunda yerini almıştır. Bu derlemede kontrollü ilaç salımı hakkında genel bir değerlendirmeden sonra ilerleyen araştırmalarla gelişen yeni teknolojilerden biyomedikal cihazlar ve bunlar arasında bulunan mikroakışkan bazlı cihazlar, mikropompalar, mikroiğneler konu edilmiştir. Bunların çeşitleri, yapısı, özellikleri, hazırlanma teknikleri, türleri, nerelerde kullanılabileceği ve ilişkili uygulamalar, kontrollü ilaç salımına getirebilecekleri avantajlar, bu konudaki ilerlemeler örneklerle incelenmiştir.
Anahtar Kelime:

RECENT TECHNOLOGIES IN CONTROLLED RELEASE DRUG DELIVERY

Öz:
Conventional drug delivery systems can be inadequate in many areas today due to limiting factors such as the narrow therapeutic window, complex dosing interval in long-term treatments, and systemic toxicity. Accordingly, a search has been carried out for new controlled drug delivery systems, which aim to localize the pharmacological activity of the drug to the desired area at the desired rate, and exhibit increased activity with less complications for more drugs. Better patient compliance can be achieved with microfluidic-based drug delivery systems, which have been developed to meet these needs, and better release control can be achieved with advanced drug applications. These systems, created by the control and manipulation of nano/micro-sized liquids, have taken their place in the controlled release platform with a unique character on a single chip. This review provides general information about controlled drug release, then discusses biomedical devices, one of the new technologies developed through advancing research, and the microfluidic devices (micropumps and microneedles) that they utilize. Their types, structures, properties, preparation techniques, where they can be used and related applications, the advantages they can bring to controlled drug delivery, and progress made on this subject are examined, with examples.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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APA Ozcelik E, ERDAL M, OZSOY Y (2022). KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. , 122 - 129. 10.26650/JARHS2022-1122852
Chicago Ozcelik Esher,ERDAL Meryem Sedef,OZSOY YILDIZ KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. (2022): 122 - 129. 10.26650/JARHS2022-1122852
MLA Ozcelik Esher,ERDAL Meryem Sedef,OZSOY YILDIZ KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. , 2022, ss.122 - 129. 10.26650/JARHS2022-1122852
AMA Ozcelik E,ERDAL M,OZSOY Y KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. . 2022; 122 - 129. 10.26650/JARHS2022-1122852
Vancouver Ozcelik E,ERDAL M,OZSOY Y KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. . 2022; 122 - 129. 10.26650/JARHS2022-1122852
IEEE Ozcelik E,ERDAL M,OZSOY Y "KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER." , ss.122 - 129, 2022. 10.26650/JARHS2022-1122852
ISNAD Ozcelik, Esher vd. "KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER". (2022), 122-129. https://doi.org/10.26650/JARHS2022-1122852
APA Ozcelik E, ERDAL M, OZSOY Y (2022). KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. Sabiad , 5(2), 122 - 129. 10.26650/JARHS2022-1122852
Chicago Ozcelik Esher,ERDAL Meryem Sedef,OZSOY YILDIZ KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. Sabiad 5, no.2 (2022): 122 - 129. 10.26650/JARHS2022-1122852
MLA Ozcelik Esher,ERDAL Meryem Sedef,OZSOY YILDIZ KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. Sabiad , vol.5, no.2, 2022, ss.122 - 129. 10.26650/JARHS2022-1122852
AMA Ozcelik E,ERDAL M,OZSOY Y KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. Sabiad . 2022; 5(2): 122 - 129. 10.26650/JARHS2022-1122852
Vancouver Ozcelik E,ERDAL M,OZSOY Y KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER. Sabiad . 2022; 5(2): 122 - 129. 10.26650/JARHS2022-1122852
IEEE Ozcelik E,ERDAL M,OZSOY Y "KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER." Sabiad , 5, ss.122 - 129, 2022. 10.26650/JARHS2022-1122852
ISNAD Ozcelik, Esher vd. "KONTROLLÜ İLAÇ SALIMINDA SON TEKNOLOJİLER". Sabiad 5/2 (2022), 122-129. https://doi.org/10.26650/JARHS2022-1122852