TY  - JOUR
TI  - An Immunohistochemical Investigation of The Effect of Sambucus Nigra on Chymase-, Tryptase- and Ghrelin- Positive Cells in Rat Lung
AB  - Sambucus nigra (S.nigra) is used in the treatment of many diseases and disorders thanks to its antioxidant, anticarcinogenic, immunostimulating, antiallergic, antiviral, and antibacterial properties. Ghrelin has anti-inflammatory effect on oxidative damage in various organs and cell types. The aim of this study was to immunohistochemically examine the chymase, tryptase, and ghrelin in rat lung after S. nigra administration. A total of 16 male rats were used in the study. The rats were assigned to two groups, control and S. nigra. 1st control group (n=8): No application was made. 2nd S. nigra group (n=8): S. nigra extract was administered at 15 mg/kg by oral gavage for 14 days. Tryptase, chymase, and ghrelin-positive cells were found in the lung tissue in a spindle-shaped, round, or oval shape. When the groups were evaluated within themselves, a significant increase in the number of tryptase, chymase, and ghrelin positive cells was observed in the S. nigra treated group. This study showed that S. nigra, which has an immunomodulatory and antioxidant effect, increases the expression of chymase-, tryptase- and ghrelin-positive cells in the lungs. Additionally, based on our findings, it can be said that mast cells can produce, store and release ghrelin.
AU  - SEVİLGEN, GÖKÇEN
AU  - ERTUĞRUL, Tuğrul
DO  - 10.30607/kvj.1070754
PY  - 2022
JO  - Kocatepe Veterinary Journal
VL  - 15
IS  - 2
SN  - 1308-1594
SP  - 209
EP  - 216
DB  - TRDizin
UR  - http://search/yayin/detay/1114151
ER  -