ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS

Tuter, Gulay; Kurtiş, Mazlum Bülent; Bozkurt Doğan, Şeyma; Sertoglu, Erdim; KIVRAK, ELİFCAN; BALLI, Umut

ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS

Elifcan KIVRAK, (Gazi Üniversitesi, Diş Hekimliği Fakültesi, Eski Periodontoloji Anabilim Dalı, Ankara, Türkiye)

Şeyma BOZKURT DOĞAN, (Ankara Yıldırım Beyazıt Üniversitesi, Diş Hekimliği Fakültesi, Eski Periodontoloji Anabilim Dalı, Ankara, Türkiye)

Erdim SERTOĞLU, (Ankara Sağlık Bilimleri Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara Türkiye)

Umut BALLI,

Mazlum Bülent KURTİŞ, (Gazi Üniversitesi, Diş Hekimliği Fakültesi, Eski Periodontoloji Anabilim Dalı, Ankara, Türkiye)

Gülay TÜTER (Gazi Üniversitesi, Diş Hekimliği Fakültesi, Eski Periodontoloji Anabilim Dalı, Ankara, Türkiye)

Clinical Dentistry and Research

3 2

Yıl: 2022 Cilt: 46 Sayı: 2 Sayfa Aralığı: 72 - 81 Metin Dili: İngilizce İndeks Tarihi: 24-08-2022

ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS

Öz:

Background and Aims: The expression of LL-37 (the active form of human cathelicidin antimicrobial peptides) can be induced by the active form of vitamin D3. We aimed to evaluate the serum vitamin D3 and gingival crevicular fluid (GCF) LL-37 levels, and periodontal clinical recordings belonging to smoker and nonsmoker patients who have periodontitis (P). Materials and Methods: 20 periodontally healthy and nonsmoker participants (control, C, mean age; 25.3±1.1), 20 smoker periodontitis patients (P-S, mean age; 42.75±5.67), and 20 non-smoker periodontitis patients (P-NS mean age; 42.7±7.55) were enrolled to this study. Periodontal clinical measurements were recorded, and the blood samples and GCF samples were collected. The levels of GCF LL-37 were analyzed by ELISA, and the serum levels of vitamin D3 were evaluated by HPLC. Results: Total amount and concentration of GCF LL-37 levels were statistically significantly higher in the P groups compared to the C group (p<0.001); however, any significant difference could not be identified between the P-S and P-NS groups in the terms of concentration and the total amount of GCF LL- 37 (respectively; p=0.479, p=0.565). When every group was examined together, it was determined that there was a statistically significant positive correlation between GCF LL-37, gingival index, and clinical attachment level (p<0.001). When the groups were evaluated separately, a statistically significant positive correlation was identified between the serum vitamin D3 levels and GCF LL-37 levels in the P-S group (p=0.033). Conclusions: Vitamin D3 might be considered a potent stimulator for GCF LL-37 levels in smoker periodontitis patients, and smoking might also influence the levels of the GCF LL-37 in patients having P.

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APA	KIVRAK E, Bozkurt Doğan Ş, Sertoglu E, BALLI U, Kurtiş M, Tuter G (2022). ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. , 72 - 81.
Chicago	KIVRAK ELİFCAN,Bozkurt Doğan Şeyma,Sertoglu Erdim,BALLI Umut,Kurtiş Mazlum Bülent,Tuter Gulay ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. (2022): 72 - 81.
MLA	KIVRAK ELİFCAN,Bozkurt Doğan Şeyma,Sertoglu Erdim,BALLI Umut,Kurtiş Mazlum Bülent,Tuter Gulay ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. , 2022, ss.72 - 81.
AMA	KIVRAK E,Bozkurt Doğan Ş,Sertoglu E,BALLI U,Kurtiş M,Tuter G ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. . 2022; 72 - 81.
Vancouver	KIVRAK E,Bozkurt Doğan Ş,Sertoglu E,BALLI U,Kurtiş M,Tuter G ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. . 2022; 72 - 81.
IEEE	KIVRAK E,Bozkurt Doğan Ş,Sertoglu E,BALLI U,Kurtiş M,Tuter G "ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS." , ss.72 - 81, 2022.
ISNAD	KIVRAK, ELİFCAN vd. "ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS". (2022), 72-81.

APA	KIVRAK E, Bozkurt Doğan Ş, Sertoglu E, BALLI U, Kurtiş M, Tuter G (2022). ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. Clinical Dentistry and Research, 46(2), 72 - 81.
Chicago	KIVRAK ELİFCAN,Bozkurt Doğan Şeyma,Sertoglu Erdim,BALLI Umut,Kurtiş Mazlum Bülent,Tuter Gulay ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. Clinical Dentistry and Research 46, no.2 (2022): 72 - 81.
MLA	KIVRAK ELİFCAN,Bozkurt Doğan Şeyma,Sertoglu Erdim,BALLI Umut,Kurtiş Mazlum Bülent,Tuter Gulay ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. Clinical Dentistry and Research, vol.46, no.2, 2022, ss.72 - 81.
AMA	KIVRAK E,Bozkurt Doğan Ş,Sertoglu E,BALLI U,Kurtiş M,Tuter G ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. Clinical Dentistry and Research. 2022; 46(2): 72 - 81.
Vancouver	KIVRAK E,Bozkurt Doğan Ş,Sertoglu E,BALLI U,Kurtiş M,Tuter G ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS. Clinical Dentistry and Research. 2022; 46(2): 72 - 81.
IEEE	KIVRAK E,Bozkurt Doğan Ş,Sertoglu E,BALLI U,Kurtiş M,Tuter G "ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS." Clinical Dentistry and Research, 46, ss.72 - 81, 2022.
ISNAD	KIVRAK, ELİFCAN vd. "ASSOCIATION BETWEEN SERUM VITAMIN D AND LL-37 LEVELS IN SMOKERS WITH PERIODONTITIS". Clinical Dentistry and Research 46/2 (2022), 72-81.