TY  - JOUR
TI  - Clinical, hormonal, radiological and morphological comparison of patients with clinically evident Cushing's disease and patients with silent corticotroph cell adenoma
AB  - Purpose: The aim of the study was to review our clinical 7 years experiences with silent corticotroph adenoma (SCA) and Cushing disease (CD) with regard to clinical, radiological features, immunohistochemical and surgical outcomes and compare the results between two groups. Material and Methods: We retrospectively reviewed a series of patients (n=17; SCA 10, CD 7) with corticotroph adenomas and collected biochemical, neuroradiological and pathological data of those during follow-up time. Results: Mean pre-operative ACTH values of the patients with CD and SCA were 60.4±29.5, 45.5±34.6 pg/mL, respectively. Mean preoperative cortisol of the patient with CD (21.2±4.4 vs 11.5±4.0 mcg/dL) was increased than the patients with SCA measurements’. Patients with SCA had larger pituitary mass (20.4±4.5 vs 8.8±4.0 mm) than the patients with CD. And cavernous sinus invasion also was determined in all patients with SCA. Sparsely granulation staining was more common in all patients with SCA (7/10) or CD (4/7). Conclusion: SCAs are totally different from functional CD adenomas related with clinical characteristics and postoperative outcomes. SCA can be thought of as a diverse group of pituitary adenomas.
AU  - Cetinalp, Nuri Eralp
AU  - EVRAN, MEHTAP
AU  - Sert, Murat
AU  - tetiker, Tamer
AU  - Akkuş, Gamze
AU  - Zorludemir, Suzan
AU  - karagun, baris
AU  - odabas, fulya
AU  - Acikalin, Arbil
DO  - 10.17826/cumj.783225
PY  - 2020
JO  - Cukurova Medical Journal
VL  - 45
IS  - 4
SN  - 2602-3032
SP  - 1720
EP  - 1732
DB  - TRDizin
UR  - http://search/yayin/detay/1115227
ER  -