Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats

Kibar, Murat; Aytmirzakızı, Ayperi; ÇAĞLAYAN, TAMER; Keskin, Abdulkadir

doi:10.33988/auvfd.869204

Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats

Murat KİBAR, (Artvin Üniversitesi, Artvin Meslek Yüksekokulu, Avcılık ve Yaban Hayatı Tıbbı Programı, Artvin, Türkiye)

ABDULKADİR KESKİN, (Bursa Uludağ Üniversite, Veteriner Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Bursa, Türkiye)

Ayperi AYTMIRZAKIZI, (Faculty of Veterinary Medicine, Kyrgyzstan Turkish Manas University, Small Animal Clinic, Bishkek, Kyrgyzstan)

TAMER ÇAĞLAYAN (Artvin Üniversitesi, Hopa Fakültesi İktisadi ve İdari Bilimler, İşletme Bölümü, Artvin, Türkiye)

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2022 Cilt: 69 Sayı: 3 Sayfa Aralığı: 251 - 257 Metin Dili: İngilizce DOI: 10.33988/auvfd.869204 İndeks Tarihi: 25-08-2022

Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats

Öz:

The aim of this study was to investigate the impact of the general anesthetic drug ketamine and premedication agents medetomidine and xylazine, and their reversal by atipamezole, on monitored anesthesia care values and ocular parameters such as intraocular pressure, horizontal pupillar diameter, and Schirmer tear test in cats. A randomized, single-blinded study was conducted. Twenty intact female cats (weiging between 2.2 and 3.6 kg, and 0.5 to 5.5 years of age) referred for ovariohysterectomy (OHE) procedure by the owners at regular intervals over 4 months were included in the study. The cats were randomly divided into two groups containing 10 animals in each group. The cats were premedicated with medetomidine 80 μg/kg intramuscular in group 1 while the cats in the 2nd group were premedicated with xylazine hydrochloride 2 mg/kg intramuscular. After the OHE procedure was ended, anesthesia regimes were reversed by using atipamezole 200 μg/kg intramuscularly. Monitoring of respiration rate, heart rate, mean arterial pressure, peripheral arterial oxygen saturation, and body temperature were conducted using a patient monitor at T0, T1, T2, T3, and T4 time points. Both groups showed declines in intraocular pressure and increases in horizontal pupil diameter after anesthesia induction (T0 vs. T1, all, P<0.05); however, the chancing and recovery pattern of intraocular pressure and horizontal pupil diameter showed intergroup difference. In conclusion, xylazine/ketamine is more effective than medetomidine/ketamine in attenuating the intraocular pressure, increasing the horizontal pupil diameter, and alteration the monitored anesthesia care response in the general anesthesia.

Anahtar Kelime:

Kedilerde medetomidin/ketamin ve ksilazin/ketamin anestezisinin ve bunların atipamezol ile etkilerinin ters çevrilmesinin oküler ve anestezi izlem parametreleri üzerindeki etkileri

Öz:

Bu çalışmanın amacı, genel anestezik ilaç ketamin ve premedikasyon ilaçları medetomidin ve ksilazinin; ve bunların etkilerinin atipamezol ile tersine çevrilmesinin göz içi basıncı, yatay pupil çapı ve Schirmer gözyaşı testi gibi kedi oküler ve anestezi izlem parametreleri üzerindeki etkilerini araştırmaktı. Rastlantısal, tek tarflı kör bir çalışma yürütüldü. Sahipleri tarafından 4 aylık süre içerisinde ovaryohisterektomi operasyonu için başvurulan 20 erişkin dişi kedi (2,2 ila 3,6 kg ve 0,5 ila 5,5 yaş arasında) çalışmaya dahil edildi. Kediler, her grupta on kedinin olduğu iki gruptan birine rastlantısal olarak dahil edildi. Grup 1'de kediler kas içi 80 μg/kg medetomidin ile premedike edilirken grup 2 deki kediler kas içi ksilazin hidroklorür 2 mg/kg ile premedike edildi. Ovariohisterektomi işlemi bittikten sonra anestezik etki kasiçi atipamezol 200 μg/kg kullanılarak ters çevrildi. Solunum sayısı, kalp atım hızı, ortalama arter kan basıncı, periferik arteriyel oksijen düzeyi ve vücut ısının izlenmesi T0, T1, T2, T3 ve T4 zaman noktalarında hastabaşı monitör kullanılarak gerçekleştirildi. Her iki grup da anestezi indüksiyonundan sonra istatistiki olarak önemli olan göz içi basıncında düşüş ve yatay pupil çapında artış gösterdi (T0'a karşı T1, tümü, P<0,05); bununla birlikte, göz içi basıncı ve yatay pupil çapının anestezideki değişim ve başlangıç değerine dönüşler gruplar arası farklıydı. Sonuç olarak ksilazin/ketamin kombinasyonu, genel anestezide göz içi basıncını azaltmada, yatay pupil çapını artırmada ve izlenen anestezi bakım parametrelerini değiştirmede medetomidin/ketamin kombinasyonundan daha etkilidir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kibar M, Keskin A, Aytmirzakızı A, ÇAĞLAYAN T (2022). Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. , 251 - 257. 10.33988/auvfd.869204
Chicago	Kibar Murat,Keskin Abdulkadir,Aytmirzakızı Ayperi,ÇAĞLAYAN TAMER Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. (2022): 251 - 257. 10.33988/auvfd.869204
MLA	Kibar Murat,Keskin Abdulkadir,Aytmirzakızı Ayperi,ÇAĞLAYAN TAMER Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. , 2022, ss.251 - 257. 10.33988/auvfd.869204
AMA	Kibar M,Keskin A,Aytmirzakızı A,ÇAĞLAYAN T Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. . 2022; 251 - 257. 10.33988/auvfd.869204
Vancouver	Kibar M,Keskin A,Aytmirzakızı A,ÇAĞLAYAN T Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. . 2022; 251 - 257. 10.33988/auvfd.869204
IEEE	Kibar M,Keskin A,Aytmirzakızı A,ÇAĞLAYAN T "Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats." , ss.251 - 257, 2022. 10.33988/auvfd.869204
ISNAD	Kibar, Murat vd. "Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats". (2022), 251-257. https://doi.org/10.33988/auvfd.869204

APA	Kibar M, Keskin A, Aytmirzakızı A, ÇAĞLAYAN T (2022). Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 69(3), 251 - 257. 10.33988/auvfd.869204
Chicago	Kibar Murat,Keskin Abdulkadir,Aytmirzakızı Ayperi,ÇAĞLAYAN TAMER Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. Ankara Üniversitesi Veteriner Fakültesi Dergisi 69, no.3 (2022): 251 - 257. 10.33988/auvfd.869204
MLA	Kibar Murat,Keskin Abdulkadir,Aytmirzakızı Ayperi,ÇAĞLAYAN TAMER Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol.69, no.3, 2022, ss.251 - 257. 10.33988/auvfd.869204
AMA	Kibar M,Keskin A,Aytmirzakızı A,ÇAĞLAYAN T Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022; 69(3): 251 - 257. 10.33988/auvfd.869204
Vancouver	Kibar M,Keskin A,Aytmirzakızı A,ÇAĞLAYAN T Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022; 69(3): 251 - 257. 10.33988/auvfd.869204
IEEE	Kibar M,Keskin A,Aytmirzakızı A,ÇAĞLAYAN T "Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats." Ankara Üniversitesi Veteriner Fakültesi Dergisi, 69, ss.251 - 257, 2022. 10.33988/auvfd.869204
ISNAD	Kibar, Murat vd. "Effects of medetomidine/ketamine and xylazine/ketamine anesthesia and their reversal by atipamezole on ocular parameters and monitored anesthesia care in cats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 69/3 (2022), 251-257. https://doi.org/10.33988/auvfd.869204