Background and Aims: Inflammatory fibroid polyp is a rare benign lesion in the gastrointestinal tract. This study aimed to discuss the clinical, morphological, and immunohistochemical features of inflammatory fibroid polyp in the gastrointestinal tract that were reported at our hospital over 10 years. Materials and Method: This study presents 22 cases of inflammatory fibroid polyp with their clinical, morphological, and immunohistochemical features. Age, gender, inflammatory fibroid polyp treatment method, tumor diameter, localization, morphological features, and immunohistochemical staining results were recorded. Results: Of the cases, 19 (86.4%) were women and 3 (13.6%) were men, with ages 44–74 years (mean age, 60 ± 6.9 years). The lesion sizes were 0.7–5.5 cm (mean size, 1.9 cm). Inflammatory fibroid polyp was most common in the stomach (n: 13), followed by the small intestine (n: 8) and colon (n: 1). Spindle cell proliferation and eosinophil infiltration accompanied by thin- and thick-walled vessels were observed in all cases. Vimentin was diffusely positive in all cases. CD34 was positive in 21 cases, and smooth muscle actin was positive in 3 cases. Estrogen receptor focal staining was performed in four cases and progesterone receptor focal staining in one case. S100, desmin, CD117, and androgen receptor were negative in all cases. Conclusions: Inflammatory fibroid polyp is localized in the submucosa, which often extends into the mucosa. Regular vascular pattern, spindle cell proliferation, and eosinophilic infiltration are typical morphological findings. Inflammatory fibroid polyp should be included in the differential diagnosis of spindle cell tumors in the gastrointestinal tract. With morphological findings other than its classical microscopic appearance, differential diagnoses should be acknowledged as difficult and diagnosis should be supported by immunohistochemical markers.