Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode
Yıl: 2022 Cilt: 9 Sayı: 3 Sayfa Aralığı: 751 - 758 Metin Dili: İngilizce DOI: 10.18596/jotcsa.998696 İndeks Tarihi: 29-08-2022
Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode
Öz: This study aims to offer a voltammetric method for determining the antipsychotic drug flupentixol from serum samples. According to pH and scan rate studies, the oxidation behavior of flupentixol at boron-doped diamond electrode was found as irreversible and diffusion-controlled. In order to determine flupentixol from bulk form and serum samples, differential pulse voltammetry was preferred as the working method because of the repeatability. Linear responses were obtained in the range of 6.0×10-7 – 8.0×10-6 M and 8.0×10-7 – 1.0×10-5 M for bulk form and serum samples in pH 2.0 Britton-Robinson buffer solution, with detection limit values of 1.09×10-7 M and 1.08×10-7 M, respectively. Required validation parameters were also studied and according to recovery from serum samples (99.91 %) and precision studies, it can be said that developed method was accurate and precise.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. World Health Organization. Depression [Internet]. 2021. <URL>.
- 2. World Health Organization. Schizophrenia [Internet]. 2019. <URL>.
- 3. Abdelbary A, Bendas ER, Ramadan AA, Mostafa DA. Pharmaceutical and Pharmacokinetic Evaluation of a Novel Fast Dissolving Film Formulation of Flupentixol Dihydrochloride. AAPS PharmSciTech. 2014 Aug;15(6):1603–10. <DOI>.
- 4. Bozal-Palabiyik B, Uslu B. A novel electroanalytical nanosensor based on MWCNT/Fe2O3 nanoparticles for the determination of antiparkinson drug ropinirole. Ionics 2015 221. 2015 Aug;22(1):115–23. <DOI>.
- 5. Uslu B, Ozkan SA. Electroanalytical application of carbon based electrodes to the pharmaceuticals. Anal Lett. 2007 Apr;40(5):817–53. <DOI>.
- 6. Yence M, Cetinkaya A, Ozcelikay G, Kaya SI, Ozkan SA. Boron-Doped Diamond Electrodes: Recent Developments and Advances in View of Electrochemical Drug Sensors. Crit Rev Anal Chem. 2021; <DOI>.
- 7. Einaga Y. Development of Electrochemical Applications of Boron-Doped Diamond Electrodes. Bull Chem Soc Jpn. 2018 Oct;91(12):1752–62. <DOI>.
- 8. Šelešovská R, Hlobeňová F, Skopalová J, Cankař P, Janíková L, Chýlková J. Electrochemical oxidation of anti-inflammatory drug meloxicam and its determination using boron doped diamond electrode. J Electroanal Chem. 2020 Feb;858:113758. <DOI>.
- 9. Zhang G, Terry A V., Bartlett MG. Bioanalytical methods for the determination of antipsychotic drugs. Biomed Chromatogr. 2008 Jul;22(7):671–87.
- 10. Dogan B, Özkan SA, Uslu B. Electrochemical characterization of flupenthixol and rapid determination of the drug in human serum and pharmaceuticals by voltammetry. Anal Lett. 2005;38(4):641–56. <DOI>.
- 11. Abdallah NA. Nanoparticles based carbon paste electrodes for the determination of flupentixol dihydrochloride: Application to pharmaceutical analysis and pharmacokinetic study. Int J Electrochem Sci. 2016;11(12):10715–31. <DOI>.
- 12. Mostafa IM, Derayea SM, Nagy DM, Omar MA. Benzofurazan-based fluorophore for the selective determination of flupentixol dihydrochloride: Application to content uniformity testing. Luminescence. 2018 Apr;33(6):1026–32. <DOI>.
- 13. Lakshminarayana B, Jose Gnana Babu G, Menaka T, Yogesh DB. Development and Validation of Second Order Spectrophotometric Method for Quantitative estimation of Flupentixol dihydrochloride in Bulk and Pharmaceutical dosage form. Int J ChemTech Res. 2011;3(2):580–3.
- 14. Sheikh IA, Charde MS, Kasture AV. Estimation of Flupenthixol HCl in single dosage form by RP-HPLC method. Int J Pharm Anal. 2009;1(2):11–9.
- 15. Zuo XC, Zhang BK, Chen BM, Liu SG, Yang GP, Liu SK, et al. LC-ESI-MS determination of flupentixol in human plasma. Chromatographia. 2009 Nov;69(3–4):301– 5. <DOI>.
- 16. Pinar PT, Saadi Ali H, Abdullah AA, Yardim Y, Şentürk Z. Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodically pretreated boron-doped diamond electrode. Marmara Pharm J. 2018;22(3):460–8. <DOI>.
| APA | PALABIYIK B (2022). Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. , 751 - 758. 10.18596/jotcsa.998696 |
| Chicago | PALABIYIK Burçin BOZAL Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. (2022): 751 - 758. 10.18596/jotcsa.998696 |
| MLA | PALABIYIK Burçin BOZAL Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. , 2022, ss.751 - 758. 10.18596/jotcsa.998696 |
| AMA | PALABIYIK B Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. . 2022; 751 - 758. 10.18596/jotcsa.998696 |
| Vancouver | PALABIYIK B Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. . 2022; 751 - 758. 10.18596/jotcsa.998696 |
| IEEE | PALABIYIK B "Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode." , ss.751 - 758, 2022. 10.18596/jotcsa.998696 |
| ISNAD | PALABIYIK, Burçin BOZAL. "Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode". (2022), 751-758. https://doi.org/10.18596/jotcsa.998696 |
| APA | PALABIYIK B (2022). Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. Journal of the Turkish Chemical Society, Section A: Chemistry, 9(3), 751 - 758. 10.18596/jotcsa.998696 |
| Chicago | PALABIYIK Burçin BOZAL Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. Journal of the Turkish Chemical Society, Section A: Chemistry 9, no.3 (2022): 751 - 758. 10.18596/jotcsa.998696 |
| MLA | PALABIYIK Burçin BOZAL Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. Journal of the Turkish Chemical Society, Section A: Chemistry, vol.9, no.3, 2022, ss.751 - 758. 10.18596/jotcsa.998696 |
| AMA | PALABIYIK B Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. Journal of the Turkish Chemical Society, Section A: Chemistry. 2022; 9(3): 751 - 758. 10.18596/jotcsa.998696 |
| Vancouver | PALABIYIK B Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode. Journal of the Turkish Chemical Society, Section A: Chemistry. 2022; 9(3): 751 - 758. 10.18596/jotcsa.998696 |
| IEEE | PALABIYIK B "Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode." Journal of the Turkish Chemical Society, Section A: Chemistry, 9, ss.751 - 758, 2022. 10.18596/jotcsa.998696 |
| ISNAD | PALABIYIK, Burçin BOZAL. "Voltammetric determination of antipsychotic drug flupentixol HCl in human serum at a boron-doped diamond electrode". Journal of the Turkish Chemical Society, Section A: Chemistry 9/3 (2022), 751-758. https://doi.org/10.18596/jotcsa.998696 |
