Objective: In the study, it was aimed to determine the health-related quality of life and related factors of children during the COVID-19 pandemic period.Materials and Methods: The cross-sectional - study was conducted with 1221 volunteer family members with children aged 8-14 in six schools in three different provinces. In the study, the socio-demographic characteristics questionnaire, the child's healthy lifestyle behaviors during the COVID-19 pandemic process, and the KIDSCREEN-27 scale were used.Results: In the study; The quality of life scores of children who are male, 12-13 years old, have four or more siblings, have a low economic family, are quiet-calm, emotional-sensitive, and have introverted personality traits have been found to be lower. In addition, the quality of life scores of children whose sleep habits, social relationships, personal hygiene habits and healthy food consumption behaviors were adversely affected during the pandemic process, whose screen exposure time increased outside of classes, and whose time they spent on reading, hobbies, sports and exercise decreased, were also found to be low.Conclusion: The study is important in terms of being a guide for intervention programs to be planned for children at risk of low quality of life.