The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children
Yıl: 2022 Cilt: 7 Sayı: 3 Sayfa Aralığı: 493 - 498 Metin Dili: İngilizce DOI: 10.26453/otjhs.1127928 İndeks Tarihi: 02-09-2022
The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children
Öz: Objective: This study aims to determine the triggering role of parvovirus B19 (PV-B19) in the pathogenesis of autoimmune thyroiditis in adolescence.Materials and Methods: Thirty-five patients aged 10-18 years who were diagnosed with Hashimoto's thyroiditis in the last 6 months were included in the study. As the control group, 35 healthy volunteers without PV-B19 associated acute disease, no goiter in physical examination, no family history of thyroid disease, and normal thyroid function tests were recruited. Serum samples were tested for PV-B19 IgM and IgG antibodies and PV-B19 DNA. Statistical analysis was performed using the SPSS.Results: PV-B19 IgM antibodies were positive in 4 (11.4%) patients and 5 (14.3%) controls whereas PV-B19 IgG antibodies were present in 13 (37.1%) patients and 6 (17.1%) controls. PV-B19 DNA was detectable in 11.4% of patients (n:4) and 14.3% of controls (n:5). There was no significant difference between the patient and control groups in terms of antibody and polymerase chain reaction positivity. In logistic regression analysis, free thyroxine level (p:0.021), anti-thyroid peroxidase antibody level (p:0.005), and isthmus thickness (p:0.021) were found to be effective on PV-B19 IgG positivity.Conclusion: Previous PV-B19 infections may be one of the triggers in the pathogenesis of Hashimoto’s thyroiditis.
Anahtar Kelime: Adolesan Çağındaki Çocuklarda Otoimmün Tiroiditte Parvovirus B19’un Rolü
Öz: Amaç: Bu çalışmanın amacı adolesan çağındaki otoimmün tiroidit patogenezinde Parvovirus B19'un (PV-B19) tetikleyici rolünü belirlemektir.Materyal ve Metot: Çalışmaya son 6 ayda Hashimoto tiroiditi tanısı konulan 10-18 yaş arası 35 hasta dahil edildi. Kontrol grubu olarak PV-B19 ile ilişkili akut hastalığı olmayan, fizik muayenesinde guatr olmayan, ailede tiroid hastalığı öyküsü olmayan ve tiroid fonksiyon testleri normal olan 35 sağlıklı gönüllü alındı. Katılımcılardan alınan serum örnekleri PV-B19 IgM ve IgG antikorları ve PV-B19 DNA için test edildi. İstatistiksel analiz SPSS programı kullanılarak yapıldı.Bulgular: Dört (%11,4) hasta ve 5 (%14,3) kontrolde PV-B19 IgM antikorları pozitif iken, 13 (%37,1) hasta ve 6 (%17,1) kontrolde PV-B19 IgG antikorları mevcuttu. PV-B19 DNA'sı hastaların %11,4'ünde (n:4) ve kontrollerin %14,3'ünde (n:5) saptandı. Antikor ve polimeraz zincir reksiyonu pozitifliği açısından hasta ve kontrol grupları arasında anlamlı fark yoktu. Lojistik regresyon analizinde PV-B19 IgG pozitifliği üzerine serbest tiroksin düzeyi (p:0,021), antitiroid peroksidaz antikor düzeyi (p:0,005) ve istmus kalınlığı (p:0,021) etkili bulundu.Sonuç: Geçirilmiş PV-B19 enfeksiyonları, Hashimoto tiroiditi patogenezinde tetikleyicilerden biri olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Durak C, Yavaş Abalı Z, Köksal M, beka h, ağaçfidan a, OĞUZ F, Bas F (2022). The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. , 493 - 498. 10.26453/otjhs.1127928 |
| Chicago | Durak Cansu,Yavaş Abalı Zehra,Köksal Muammer Osman,beka hayati,ağaçfidan ali,OĞUZ FATMA,Bas Firdevs The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. (2022): 493 - 498. 10.26453/otjhs.1127928 |
| MLA | Durak Cansu,Yavaş Abalı Zehra,Köksal Muammer Osman,beka hayati,ağaçfidan ali,OĞUZ FATMA,Bas Firdevs The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. , 2022, ss.493 - 498. 10.26453/otjhs.1127928 |
| AMA | Durak C,Yavaş Abalı Z,Köksal M,beka h,ağaçfidan a,OĞUZ F,Bas F The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. . 2022; 493 - 498. 10.26453/otjhs.1127928 |
| Vancouver | Durak C,Yavaş Abalı Z,Köksal M,beka h,ağaçfidan a,OĞUZ F,Bas F The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. . 2022; 493 - 498. 10.26453/otjhs.1127928 |
| IEEE | Durak C,Yavaş Abalı Z,Köksal M,beka h,ağaçfidan a,OĞUZ F,Bas F "The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children." , ss.493 - 498, 2022. 10.26453/otjhs.1127928 |
| ISNAD | Durak, Cansu vd. "The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children". (2022), 493-498. https://doi.org/10.26453/otjhs.1127928 |
| APA | Durak C, Yavaş Abalı Z, Köksal M, beka h, ağaçfidan a, OĞUZ F, Bas F (2022). The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. Online Türk Sağlık Bilimleri Dergisi, 7(3), 493 - 498. 10.26453/otjhs.1127928 |
| Chicago | Durak Cansu,Yavaş Abalı Zehra,Köksal Muammer Osman,beka hayati,ağaçfidan ali,OĞUZ FATMA,Bas Firdevs The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. Online Türk Sağlık Bilimleri Dergisi 7, no.3 (2022): 493 - 498. 10.26453/otjhs.1127928 |
| MLA | Durak Cansu,Yavaş Abalı Zehra,Köksal Muammer Osman,beka hayati,ağaçfidan ali,OĞUZ FATMA,Bas Firdevs The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. Online Türk Sağlık Bilimleri Dergisi, vol.7, no.3, 2022, ss.493 - 498. 10.26453/otjhs.1127928 |
| AMA | Durak C,Yavaş Abalı Z,Köksal M,beka h,ağaçfidan a,OĞUZ F,Bas F The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. Online Türk Sağlık Bilimleri Dergisi. 2022; 7(3): 493 - 498. 10.26453/otjhs.1127928 |
| Vancouver | Durak C,Yavaş Abalı Z,Köksal M,beka h,ağaçfidan a,OĞUZ F,Bas F The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children. Online Türk Sağlık Bilimleri Dergisi. 2022; 7(3): 493 - 498. 10.26453/otjhs.1127928 |
| IEEE | Durak C,Yavaş Abalı Z,Köksal M,beka h,ağaçfidan a,OĞUZ F,Bas F "The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children." Online Türk Sağlık Bilimleri Dergisi, 7, ss.493 - 498, 2022. 10.26453/otjhs.1127928 |
| ISNAD | Durak, Cansu vd. "The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children". Online Türk Sağlık Bilimleri Dergisi 7/3 (2022), 493-498. https://doi.org/10.26453/otjhs.1127928 |
