TY  - JOUR
TI  - The Role of Parvovirus-B19 in Autoimmune Thyroiditis in Adolescent Children
AB  - Objective: This study aims to determine the triggering role of parvovirus B19 (PV-B19) in the pathogenesis of autoimmune thyroiditis in adolescence.Materials and Methods: Thirty-five patients aged 10-18 years who were diagnosed with Hashimoto's thyroiditis in the last 6 months were included in the study. As the control group, 35 healthy volunteers without PV-B19 associated acute disease, no goiter in physical examination, no family history of thyroid disease, and normal thyroid function tests were recruited. Serum samples were tested for PV-B19 IgM and IgG antibodies and PV-B19 DNA. Statistical analysis was performed using the SPSS.Results: PV-B19 IgM antibodies were positive in 4 (11.4%) patients and 5 (14.3%) controls whereas PV-B19 IgG antibodies were present in 13 (37.1%) patients and 6 (17.1%) controls. PV-B19 DNA was detectable in 11.4% of patients (n:4) and 14.3% of controls (n:5). There was no significant difference between the patient and control groups in terms of antibody and polymerase chain reaction positivity. In logistic regression analysis, free thyroxine level (p:0.021), anti-thyroid peroxidase antibody level (p:0.005), and isthmus thickness (p:0.021) were found to be effective on PV-B19 IgG positivity.Conclusion: Previous PV-B19 infections may be one of the triggers in the pathogenesis of Hashimoto’s thyroiditis. 
AU  - Yavaş Abalı, Zehra
AU  - beka, hayati
AU  - ağaçfidan, ali
AU  - OĞUZ, FATMA
AU  - Köksal, Muammer Osman
AU  - Durak, Cansu
AU  - Bas, Firdevs
DO  - 10.26453/otjhs.1127928
PY  - 2022
JO  - Online Türk Sağlık Bilimleri Dergisi
VL  - 7
IS  - 3
SN  - 2459-1467
SP  - 493
EP  - 498
DB  - TRDizin
UR  - http://search/yayin/detay/1117937
ER  -