TY  - JOUR
TI  - The protective effects of Selenium and Boron against Cyclophosphamide-induced bone marrow and blood toxicity: An in vivo study
AB  - Thanks to their antioxidant, anti-apoptotic, anti-lipid peroxidative, and immune-boosting properties, Boron (B) and Selenium (Se) are essential trace elements for the human body. This study aims to compare the myeloid protective potentials of Se and B in Cyclophosphamide (CP)-induced bone-marrow and haematological toxicity in experimental rats considering that the myelotoxic property of this anti-cancer drug limits its use. We hypothesized that selenium has a better protective effect than boron in preventing the toxic effects of CP on bone marrow and blood cells. 1.5 mg/kg of Se and 20 mg/kg of B, which are the most frequently used optimal doses of these trace elements, were given to the animals intraperitoneally throughout the experiment. 200 mg/kg of CP was administered only on the 4th day. The animals were sacrificed to take the blood and bone marrow samples to be stored for hematological evaluations. The CP administration significantly decreased leukocyte (WBC), thrombocyte (PLT), erythrocytes (RBC), and bone marrow nucleated cell counts. On the other hand, they increased in significant amounts in the groups given Se and B along with CP when compared to those given only CP. However, Se proved to be more protective than B in preventing CP-induced bone marrow and hematologic toxicity despite not achieving statistical significance. It was, therefore, concluded that the doses used in this experiment were successful in protecting against CP-induced damage to the bone marrow and CP-related hematological toxicity.
AU  - GÜR, Fatma
AU  - BİLİCİ, NAMIK
AU  - Ayhanci, Adnan
AU  - Musmul, Ahmet
AU  - GÜR, Bahri
AU  - Lafcı, Nilüfer
AU  - Vejselova Sezer, Canan
AU  - CENGİZ, Mustafa
AU  - onur, suzan
AU  - Kulcanay Sahin, İlknur
DO  - 10.46309/biodicon.2022.1124346
PY  - 2022
JO  - Biological Diversity and Conservation
VL  - 15
IS  - 2
SN  - 1308-5301
SP  - 256
EP  - 264
DB  - TRDizin
UR  - http://search/yayin/detay/1118559
ER  -