The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients

Oymak, Oktay; KOÇYIGIT, ISMAIL; Uysal, Cihan; SIPAHIOGLU, MURAT HAYRI; AKGÜN, HÜLYA; Tokgoz, Bulent; Koyuncu, sumeyra; Karakukcu, Cigdem; Ertürk Zararsız, Gözde

doi:10.5455/annalsmedres.2021.11.607

The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients

Sümeyra KOYUNCU, (Erciyes Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kayseri, Türkiye)

Cihan UYSAL, (Erciyes Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kayseri, Türkiye)

İSMAİL KOÇYİĞİT, (Erciyes Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kayseri, Türkiye)

Murat Hayri SİPAHİOĞLU, (Erciyes Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kayseri, Türkiye)

Oktay OYMAK, (Erciyes Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kayseri, Türkiye)

Bülent TOKGÖZ, (Erciyes Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kayseri, Türkiye)

Hülya AKGÜN, (Erciyes Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Kayseri, Türkiye)

Çiğdem KARAKÜKCÜ, (Erciyes Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Gözde Ertürk ZARARSIZ (Erciyes Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Kayseri, Türkiye)

Annals of Medical Research

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Yıl: 2022 Cilt: 29 Sayı: 7 Sayfa Aralığı: 664 - 667 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2021.11.607 İndeks Tarihi: 07-09-2022

The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients

Öz:

Abstract Aim: We aim to examine the role of HIF-2αon chronic allograft nephropathy (CAN), which is a consequence of chronic inflammation and fibrosis in patients with renal trans- plantation. Materials and Methods: The study was conducted between November 2019 and Jan- uary 2021, patients who had a renal biopsy in our university in the last two years were enrolled in this study. Fifteen recipients with a diagnosis of chronic allograft nephropa- thy proven by biopsy, 15 recipients with an eGFR below 60 ml/dk for other reasons as non-CAN group. Also, fifteen patients with an eGFR above 60 ml/dk were enrolled in the study as a control group. Serum HIF-2αlevels were analyzed by the immunoassay technique. Results: HIF-2αwas found higher in the CAN group compared to other groups. HIF-2α was significantly predictive in ROC analysis in identifying renal transplantation patients with CAN. The sensitivity and specificity of HIF-2αwere 100% and 76% (cut off >0.2) with an area of under the ROC curve of 0.941 (95% CI 0. 850-1.000), p < 0.001). Conclusion: Serum HIF-2αmay be useful both as potential biomarkers for diagnosing CAN after kidney transplantation and may be a guide in determining treatment strategies.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Koyuncu s, Uysal C, KOÇYIGIT I, SIPAHIOGLU M, Oymak O, Tokgoz B, AKGÜN H, Karakukcu C, Ertürk Zararsız G (2022). The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. , 664 - 667. 10.5455/annalsmedres.2021.11.607
Chicago	Koyuncu sumeyra,Uysal Cihan,KOÇYIGIT ISMAIL,SIPAHIOGLU MURAT HAYRI,Oymak Oktay,Tokgoz Bulent,AKGÜN HÜLYA,Karakukcu Cigdem,Ertürk Zararsız Gözde The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. (2022): 664 - 667. 10.5455/annalsmedres.2021.11.607
MLA	Koyuncu sumeyra,Uysal Cihan,KOÇYIGIT ISMAIL,SIPAHIOGLU MURAT HAYRI,Oymak Oktay,Tokgoz Bulent,AKGÜN HÜLYA,Karakukcu Cigdem,Ertürk Zararsız Gözde The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. , 2022, ss.664 - 667. 10.5455/annalsmedres.2021.11.607
AMA	Koyuncu s,Uysal C,KOÇYIGIT I,SIPAHIOGLU M,Oymak O,Tokgoz B,AKGÜN H,Karakukcu C,Ertürk Zararsız G The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. . 2022; 664 - 667. 10.5455/annalsmedres.2021.11.607
Vancouver	Koyuncu s,Uysal C,KOÇYIGIT I,SIPAHIOGLU M,Oymak O,Tokgoz B,AKGÜN H,Karakukcu C,Ertürk Zararsız G The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. . 2022; 664 - 667. 10.5455/annalsmedres.2021.11.607
IEEE	Koyuncu s,Uysal C,KOÇYIGIT I,SIPAHIOGLU M,Oymak O,Tokgoz B,AKGÜN H,Karakukcu C,Ertürk Zararsız G "The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients." , ss.664 - 667, 2022. 10.5455/annalsmedres.2021.11.607
ISNAD	Koyuncu, sumeyra vd. "The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients". (2022), 664-667. https://doi.org/10.5455/annalsmedres.2021.11.607

APA	Koyuncu s, Uysal C, KOÇYIGIT I, SIPAHIOGLU M, Oymak O, Tokgoz B, AKGÜN H, Karakukcu C, Ertürk Zararsız G (2022). The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. Annals of Medical Research, 29(7), 664 - 667. 10.5455/annalsmedres.2021.11.607
Chicago	Koyuncu sumeyra,Uysal Cihan,KOÇYIGIT ISMAIL,SIPAHIOGLU MURAT HAYRI,Oymak Oktay,Tokgoz Bulent,AKGÜN HÜLYA,Karakukcu Cigdem,Ertürk Zararsız Gözde The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. Annals of Medical Research 29, no.7 (2022): 664 - 667. 10.5455/annalsmedres.2021.11.607
MLA	Koyuncu sumeyra,Uysal Cihan,KOÇYIGIT ISMAIL,SIPAHIOGLU MURAT HAYRI,Oymak Oktay,Tokgoz Bulent,AKGÜN HÜLYA,Karakukcu Cigdem,Ertürk Zararsız Gözde The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. Annals of Medical Research, vol.29, no.7, 2022, ss.664 - 667. 10.5455/annalsmedres.2021.11.607
AMA	Koyuncu s,Uysal C,KOÇYIGIT I,SIPAHIOGLU M,Oymak O,Tokgoz B,AKGÜN H,Karakukcu C,Ertürk Zararsız G The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. Annals of Medical Research. 2022; 29(7): 664 - 667. 10.5455/annalsmedres.2021.11.607
Vancouver	Koyuncu s,Uysal C,KOÇYIGIT I,SIPAHIOGLU M,Oymak O,Tokgoz B,AKGÜN H,Karakukcu C,Ertürk Zararsız G The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients. Annals of Medical Research. 2022; 29(7): 664 - 667. 10.5455/annalsmedres.2021.11.607
IEEE	Koyuncu s,Uysal C,KOÇYIGIT I,SIPAHIOGLU M,Oymak O,Tokgoz B,AKGÜN H,Karakukcu C,Ertürk Zararsız G "The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients." Annals of Medical Research, 29, ss.664 - 667, 2022. 10.5455/annalsmedres.2021.11.607
ISNAD	Koyuncu, sumeyra vd. "The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients". Annals of Medical Research 29/7 (2022), 664-667. https://doi.org/10.5455/annalsmedres.2021.11.607