TY  - JOUR
TI  - The relationship between HIF-2 and chronic renal allograft nephropathy in renal transplantation recipients
AB  - Abstract Aim: We aim to examine the role of HIF-2αon chronic allograft nephropathy (CAN), which is a consequence of chronic inflammation and fibrosis in patients with renal trans- plantation. Materials and Methods: The study was conducted between November 2019 and Jan- uary 2021, patients who had a renal biopsy in our university in the last two years were enrolled in this study. Fifteen recipients with a diagnosis of chronic allograft nephropa- thy proven by biopsy, 15 recipients with an eGFR below 60 ml/dk for other reasons as non-CAN group. Also, fifteen patients with an eGFR above 60 ml/dk were enrolled in the study as a control group. Serum HIF-2αlevels were analyzed by the immunoassay technique. Results: HIF-2αwas found higher in the CAN group compared to other groups. HIF-2α was significantly predictive in ROC analysis in identifying renal transplantation patients with CAN. The sensitivity and specificity of HIF-2αwere 100% and 76% (cut off >0.2) with an area of under the ROC curve of 0.941 (95% CI 0. 850-1.000), p < 0.001). Conclusion: Serum HIF-2αmay be useful both as potential biomarkers for diagnosing CAN after kidney transplantation and may be a guide in determining treatment strategies.
AU  - Oymak, Oktay
AU  - KOÇYIGIT, ISMAIL
AU  - Uysal, Cihan
AU  - SIPAHIOGLU, MURAT HAYRI
AU  - AKGÜN, HÜLYA
AU  - Tokgoz, Bulent
AU  - Koyuncu, sumeyra
AU  - Karakukcu, Cigdem
AU  - Ertürk Zararsız, Gözde
DO  - 10.5455/annalsmedres.2021.11.607
PY  - 2022
JO  - Annals of Medical Research
VL  - 29
IS  - 7
SN  - 2636-7688
SP  - 664
EP  - 667
DB  - TRDizin
UR  - http://search/yayin/detay/1118859
ER  -