TY  - JOUR
TI  - Microvillus Inclusion Disease: Can Mesenchymal Stem Cells Be a Potential Treatment Option?
AB  - Microvillus inclusion disease (MVID; MIM #251850), is a rare life-threatening secretory and malabsorptive diarrhea of infancy due to mutations in the MYO5B gene. A 6-day-old male patient was referred to our neonatal intensive care unit for profuse diarrhea beginning on the 2nd day of life causing 17% weight loss, metabolic acidosis and hyponatremia. Our patient had a homozygous mutation in the MYO5B gene. On 110th day of life, mesenchymal stem cell treatment (1x106 cells trans duodenal and 2x106 cells intravenous) was administered. Although fluid and electrolyte requirements did not decrease after stem cell therapy, the rate of blood stream infections was reduced. Small bowel transplantation using cadaveric intestine was performed at the age of 20 months. Unfortunately, the infant died of sepsis one month after transplantation. In this case report, results of stem cell therapy in a newborn infant with MVID were presented and discussed with the relevant literature.  
AU  - SÜRMELI ONAY, OZGE
AU  - TEKIN, AYSE NESLIHAN
AU  - AYDEMIR, OZGE
AU  - Aydemir, Yusuf
AU  - ARTAN, Sevilhan
AU  - gunes, damla
DO  - 10.20515/otd.924631
PY  - 2022
JO  - Osmangazi Tıp Dergisi
VL  - 44
IS  - 1
SN  - 1305-4953
SP  - 125
EP  - 128
DB  - TRDizin
UR  - http://search/yayin/detay/1118984
ER  -