TY  - JOUR
TI  - Escitalopram co-prescription in anastrozole-treated breast cancer patients
AB  - OBJECTIVE: The purpose of the study was to evaluate the impact of escitalopram co-prescription on plasma anastrozole levels in post-menopausal breast cancer patients. METHODS: A total of 24 post-menopausal operated breast cancer patients co-prescribed with escitalopram and anastrozole were included. Blood samples were collected, before and 1-month after the onset of escitalopram to analyze plasma anastrozole and estradiol levels. RESULTS: No significant difference was noted in basal plasma anastrozole levels with respect to age, body mass index (BMI), tumor stage, previous antineoplastic treatments, concomitant medications, and serum estradiol levels. Overall, 17 patients completed the 1-month escitalopram treatment, while 7 patients discontinued escitalopram within the 1st week of the treatment. Basal anastrozole levels of 24 patients were 26.1±2.4 ng/mL. Among 17 patients who continued 1-month escitalopram treatment was associated with significant increase in plasma anastrozole levels (24.5±2.3 ng/mL to 32.2±3.2 ng/mL, p<0.05). Notably, 1-month escitalopram use was associated with significant increase in plasma anastrozole levels only in the subgroup of obese (BMI >29 kg/m2 ) patients (23.1±2.8 to 35.9±4.7 ng/mL, p<0.01), while no such interaction was noted among non-obese patients. The estradiol levels of the patients were below ≤10 pg/mL in 75% of patients and no change occurred after escitalopram administration. CONCLUSION: Escitalopram co-prescription resulted in significant increase in plasma anastrozole levels without affecting the serum estradiol levels. Our findings emphasize the need for close monitoring in case of concomitant use of anastrozole and escitalopram, especially in obese patients and the potential role of therapeutic drug monitoring.
AU  - Neşetoğlu, Neşet
AU  - Gemici, Cengiz
AU  - Odabas, Hatice
AU  - UNAL, DURİ SEHVAR
AU  - Küçükibrahimoğlu, Elif Esra
AU  - Özyurt, Hazan
AU  - Ozden, Sevgi
AU  - Gören, M. Zafer
AU  - yaprak, gokhan
AU  - ÜLER, PINAR
AU  - Tepetam, Hüseyin
AU  - Gumus, Mahmut
DO  - 10.14744/nci.2022.48264
PY  - 2022
JO  - İstanbul Kuzey Klinikleri
VL  - 9
IS  - 3
SN  - 2148-4902
SP  - 248
EP  - 255
DB  - TRDizin
UR  - http://search/yayin/detay/1119302
ER  -