Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation
Yıl: 2022 Cilt: 9 Sayı: 3 Sayfa Aralığı: 282 - 285 Metin Dili: İngilizce DOI: 10.14744/nci.2020.66049 İndeks Tarihi: 07-09-2022
Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation
Öz: Cerebral toxoplasmosis is a rare but often life-threatening infection after hematopoietic stem cell transplantation (HSCT). In such cases, early diagnosis and initiation of treatment are vital. We describe a case of cerebral toxoplasmosis in a patient who underwent HSCT for acute myeloid leukemia. Infection was diagnosed with polymerase chain reaction (PCR) test of cerebrospinal fluid and cranial magnetic resonance imaging scan. The patient treated with trimethoprim-sulfamethoxazole and clindamycin combination. However, she died from nosocomial infection after 15 days of treatment. This life-threatening infection should be considered in a patient who is post-HSCT present with neurologic symptoms and brain lesions. PCR is an important and rapid diagnostic tool for toxoplasmosis. Cranial imaging scan and PCR should be used together to diagnosed.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet 2004;363:1965–76.
- 2. Meers S, Lagrou K, Theunissen K, Dierickx D, Delforge M, Devos T, et al. Myeloablative conditioning predisposes patients for Toxoplasma gondii reactivation after allogeneic stem cell transplantation. Clin Infect Dis 2010;50:1127–34.
- 3. Hakko E, Ozkan HA, Karaman K, Gulbas Z. Analysis of cerebral toxoplasmosis in a series of 170 allogeneic hematopoietic stem cell transplant patients. Transpl Infect Dis 2013;15:575–80.
- 4. Miyagi T, Itonaga H, Aosai F, Taguchi J, Norose K, Mochizuki K, et al. Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two case reports and review of the literature. Transpl Infect Dis 2015;17:593–8.
- 5. Maschke M, Dietrich U, Prumbaum M, Kastrup O, Turowski B, Schaefer UW, et al. Opportunistic CNS infection after bone marrow transplantation. Bone Marrow Transplant 1999;23:1167–76.
- 6. Sumi M, Aosai F, Norose K, Takeda W, Kirihara T, Sato K, et al. Acute exacerbation of Toxoplasma gondii infection after hematopoietic stem cell transplantation: five case reports among 279 recipients. Int J Hematol 2013;98:214–22.
- 7. Mulanovich VE, Ahmed SI, Öztürk T, Khokhar FA, Kontoyiannis DP, de Lima M. Toxoplasmosis in allo-SCT patients: risk factors and outcomes at a transplantation center with a low incidence. Bone Marrow Transplant 2011;46:273–7.
- 8. Khalaf AM, Hashim MA, Alsharabati M, Fallon K, Cure JK, Pappas P, et al. Late-onset cerebral toxoplasmosis after allogeneic hematopoietic stem cell transplantation. Am J Case Rep 2017;18:246–50.
- 9. Small TN, Leung L, Stiles J, Kiehn TE, Malak SA, O’Reilly RJ, et al. Disseminated toxoplasmosis following T cell-depleted related and unrelated bone marrow transplantation. Bone Marrow Transplant 2000;25:969–73.
- 10. Park SK, Choi JK, Yoo C, Park SJ, Lee TH, Lee JH, et al. Toxoplasma encephalitis in an allogeneic hematopoietic stem cell transplant recipient in Korea. Korean J Intern Med 2012;27:235–8.
- 11. Senoo Y, Sekiya N, Sasaki S, Yoshioka K, Watakabe-Inamoto K, Hagino T, et al. Diagnostic open brain biopsy following initial negative results of cerebrospinal fluid assessment for Toxoplasma. Transpl Infect Dis 2017;19.
- 12. Martino R, Bretagne S, Einsele H, Maertens J, Ullmann AJ, Parody R, et al; Infectious Disease Working Party of the European Group for Blood and Marrow Transplantation. Early detection of Toxoplasma infection by molecular monitoring of Toxoplasma gondii in peripheral blood samples after allogeneic stem cell transplantation. Clin Infect Dis 2005;40:67–78.
- 13. Robert-Gangneux F, Dardé ML. Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev 2012;25:264–96. Erratum in: Clin Microbiol Rev 2012;25:583.
- 14. Cinque P, Scarpellini P, Vago L, Linde A, Lazzarin A. Diagnosis of central nervous system complications in HIV-infected patients: cerebrospinal fluid analysis by the polymerase chain reaction. AIDS 1997;11:1–17.
- 15. Cibickova L, Horacek J, Prasil P, Slovacek L, Kohout A, Cerovsky V, et al. Cerebral toxoplasmosis in an allogeneic peripheral stem cell transplant recipient: case report and review of literature. Transpl Infect Dis 2007;9:332–5.
| APA | izci çetinkaya f, Mumcu N, Kalin Unuvar G, A, Kaynar L (2022). Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. , 282 - 285. 10.14744/nci.2020.66049 |
| Chicago | izci çetinkaya feyza,Mumcu Necati,Kalin Unuvar Gamze, Aysegul,Kaynar Leylagul Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. (2022): 282 - 285. 10.14744/nci.2020.66049 |
| MLA | izci çetinkaya feyza,Mumcu Necati,Kalin Unuvar Gamze, Aysegul,Kaynar Leylagul Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. , 2022, ss.282 - 285. 10.14744/nci.2020.66049 |
| AMA | izci çetinkaya f,Mumcu N,Kalin Unuvar G, A,Kaynar L Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. . 2022; 282 - 285. 10.14744/nci.2020.66049 |
| Vancouver | izci çetinkaya f,Mumcu N,Kalin Unuvar G, A,Kaynar L Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. . 2022; 282 - 285. 10.14744/nci.2020.66049 |
| IEEE | izci çetinkaya f,Mumcu N,Kalin Unuvar G, A,Kaynar L "Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation." , ss.282 - 285, 2022. 10.14744/nci.2020.66049 |
| ISNAD | izci çetinkaya, feyza vd. "Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation". (2022), 282-285. https://doi.org/10.14744/nci.2020.66049 |
| APA | izci çetinkaya f, Mumcu N, Kalin Unuvar G, A, Kaynar L (2022). Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. İstanbul Kuzey Klinikleri, 9(3), 282 - 285. 10.14744/nci.2020.66049 |
| Chicago | izci çetinkaya feyza,Mumcu Necati,Kalin Unuvar Gamze, Aysegul,Kaynar Leylagul Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. İstanbul Kuzey Klinikleri 9, no.3 (2022): 282 - 285. 10.14744/nci.2020.66049 |
| MLA | izci çetinkaya feyza,Mumcu Necati,Kalin Unuvar Gamze, Aysegul,Kaynar Leylagul Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. İstanbul Kuzey Klinikleri, vol.9, no.3, 2022, ss.282 - 285. 10.14744/nci.2020.66049 |
| AMA | izci çetinkaya f,Mumcu N,Kalin Unuvar G, A,Kaynar L Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. İstanbul Kuzey Klinikleri. 2022; 9(3): 282 - 285. 10.14744/nci.2020.66049 |
| Vancouver | izci çetinkaya f,Mumcu N,Kalin Unuvar G, A,Kaynar L Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation. İstanbul Kuzey Klinikleri. 2022; 9(3): 282 - 285. 10.14744/nci.2020.66049 |
| IEEE | izci çetinkaya f,Mumcu N,Kalin Unuvar G, A,Kaynar L "Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation." İstanbul Kuzey Klinikleri, 9, ss.282 - 285, 2022. 10.14744/nci.2020.66049 |
| ISNAD | izci çetinkaya, feyza vd. "Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation". İstanbul Kuzey Klinikleri 9/3 (2022), 282-285. https://doi.org/10.14744/nci.2020.66049 |
