Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic

YETKIN, FUNDA; OZDEN, MEHMET; Gezer, Yakup; BAYINDIR, Yasar; Ersoy, Yasemin; ALTUNIŞIK TOPLU, SİBEL; Yüksel, Mustafa; Köse, Adem

doi:10.5455/annalsmedres.2022.01.022

Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic

Yakup GEZER, (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Sibel TOPLU, (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Mustafa Yüksel, (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Adem KÖSE, (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Funda MEMİŞOĞLU, (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Mehmet OZDEN, (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Yasar BAYİNDİR, (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Yasemin ERSOY (İnönü Üniversitesi Tıp Fakültesi Enfeksiyon Hastalıkları Ana Bilim Dalı, Malatya, Türkiye)

Annals of Medical Research

6 2

Yıl: 2022 Cilt: 29 Sayı: 7 Sayfa Aralığı: 743 - 747 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2022.01.022 İndeks Tarihi: 07-09-2022

Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic

Öz:

Abstract Aim: Antiretroviral therapy (ART) regimens used in the treatment of HIV are assumed to suppress the virus in plasma indefinitely and restore CD4 lymphocyte count. There is increasing evidence that a reversed CD4/CD8 ratio is associated with immune dysfunction, even in patients who have achieved virological suppression with ART and have elevated CD4 lymphocytes. The CD4/CD8 ratio has emerged as a guiding marker as an indicator of immunoactivation in HIV-infected patients. It was aimed to evaluate the CD4/CD8 ratio of HIV-diagnosed patients at baseline and at follow-up after ART regimen. Materials and Methods: A total of 150 patients were included in the study by retrospectively scanning the CD4/CD8 ratio at the initial and 24th week of follow-up in patients who were diagnosed with HIV and started treatment in the Infectious Diseases and Clinical Microbiology Clinic of the Hospital of the Medical Faculty between 2011-2021. ART treatment regimens were divided into three groups as nucleoside reverse transcriptase inhibitor (NRTI)+protease inhibitor (PI), NRTI+non-nucleoside reverse transcriptase inhibitor (NNRTI) or NRTI+ integrase strand transfer inhibitor (INSTI). Results: A total of 150 patients were included in the study. While the initial CD4/CD8 ratio of the patients was 0.36, it increased to 0.61 at the 24th week of treatment. Among the 144 patients whose baseline values were CD4/CD8<1, the rate of the ones who achieved CD4/CD8≥1 value at week 24 after ART regimens was found as 13.2% (19/144). It was observed that the CD4/CD8 ratio in the group receiving INSTI was higher (15.1%) than those of the other groups. The undetectable HIV RNA level after treatment was significantly mostly observed in the group, receiving the integrase-based regimen, with 77.1%. With effective ART, CD4/CD8 normalization is higher in individuals with high CD4 T cell counts before treatment. There was a significant increase in the CD4/CD8 ratio in all three ART regimen groups. However, most of the patients who achieved a CD4/CD8 ratio ≥1 were in the INSTI-based ART group. Conclusion: The CD4/CD8 ratio may contribute to clinical evaluation in long-term follow-up as a marker of immunological response in individuals treated with a diagnosis of HIV.

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APA	Gezer Y, ALTUNIŞIK TOPLU S, Yüksel M, Köse A, YETKIN F, OZDEN M, BAYINDIR Y, Ersoy Y (2022). Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. , 743 - 747. 10.5455/annalsmedres.2022.01.022
Chicago	Gezer Yakup,ALTUNIŞIK TOPLU SİBEL,Yüksel Mustafa,Köse Adem,YETKIN FUNDA,OZDEN MEHMET,BAYINDIR Yasar,Ersoy Yasemin Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. (2022): 743 - 747. 10.5455/annalsmedres.2022.01.022
MLA	Gezer Yakup,ALTUNIŞIK TOPLU SİBEL,Yüksel Mustafa,Köse Adem,YETKIN FUNDA,OZDEN MEHMET,BAYINDIR Yasar,Ersoy Yasemin Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. , 2022, ss.743 - 747. 10.5455/annalsmedres.2022.01.022
AMA	Gezer Y,ALTUNIŞIK TOPLU S,Yüksel M,Köse A,YETKIN F,OZDEN M,BAYINDIR Y,Ersoy Y Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. . 2022; 743 - 747. 10.5455/annalsmedres.2022.01.022
Vancouver	Gezer Y,ALTUNIŞIK TOPLU S,Yüksel M,Köse A,YETKIN F,OZDEN M,BAYINDIR Y,Ersoy Y Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. . 2022; 743 - 747. 10.5455/annalsmedres.2022.01.022
IEEE	Gezer Y,ALTUNIŞIK TOPLU S,Yüksel M,Köse A,YETKIN F,OZDEN M,BAYINDIR Y,Ersoy Y "Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic." , ss.743 - 747, 2022. 10.5455/annalsmedres.2022.01.022
ISNAD	Gezer, Yakup vd. "Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic". (2022), 743-747. https://doi.org/10.5455/annalsmedres.2022.01.022

APA	Gezer Y, ALTUNIŞIK TOPLU S, Yüksel M, Köse A, YETKIN F, OZDEN M, BAYINDIR Y, Ersoy Y (2022). Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. Annals of Medical Research, 29(7), 743 - 747. 10.5455/annalsmedres.2022.01.022
Chicago	Gezer Yakup,ALTUNIŞIK TOPLU SİBEL,Yüksel Mustafa,Köse Adem,YETKIN FUNDA,OZDEN MEHMET,BAYINDIR Yasar,Ersoy Yasemin Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. Annals of Medical Research 29, no.7 (2022): 743 - 747. 10.5455/annalsmedres.2022.01.022
MLA	Gezer Yakup,ALTUNIŞIK TOPLU SİBEL,Yüksel Mustafa,Köse Adem,YETKIN FUNDA,OZDEN MEHMET,BAYINDIR Yasar,Ersoy Yasemin Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. Annals of Medical Research, vol.29, no.7, 2022, ss.743 - 747. 10.5455/annalsmedres.2022.01.022
AMA	Gezer Y,ALTUNIŞIK TOPLU S,Yüksel M,Köse A,YETKIN F,OZDEN M,BAYINDIR Y,Ersoy Y Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. Annals of Medical Research. 2022; 29(7): 743 - 747. 10.5455/annalsmedres.2022.01.022
Vancouver	Gezer Y,ALTUNIŞIK TOPLU S,Yüksel M,Köse A,YETKIN F,OZDEN M,BAYINDIR Y,Ersoy Y Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic. Annals of Medical Research. 2022; 29(7): 743 - 747. 10.5455/annalsmedres.2022.01.022
IEEE	Gezer Y,ALTUNIŞIK TOPLU S,Yüksel M,Köse A,YETKIN F,OZDEN M,BAYINDIR Y,Ersoy Y "Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic." Annals of Medical Research, 29, ss.743 - 747, 2022. 10.5455/annalsmedres.2022.01.022
ISNAD	Gezer, Yakup vd. "Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic". Annals of Medical Research 29/7 (2022), 743-747. https://doi.org/10.5455/annalsmedres.2022.01.022