TY  - JOUR
TI  - Synthesis and Characterization of Thiazole Compounds in the Presence of Various Reagents, Catalysts and Solvents
AB  - The reaction medium plays a key role in organic synthesis and pharmaceutical research. There are many opinions on choosing the best condition, including cost and environmental implications, but the main requirement is that they have the necessary interaction with solvents to cause dissolution, precipitation, stabilization, or instability. For this purpose, in this article synthesis of the thiazole ring was made under various reaction conditions. So new compounds 2-(isoquinolin-5-ylimino)-3-phenylthiazolidin-4-one (1), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (2), (4-amino-3-phenylthiazol-2(3H)-ylidene) isoquinolin-5-amine (3) were synthesized from the reaction between thiourea derivative and monochloroacetic acid, diethyloxalate and chloro acetonitrile. For this synthesizes were created in various reaction conditions, using different bases (sodium acetate/sodyum etoksit/ triethylamine or pyridine) and solvents (1,4-dioxane, toluene, acetic acid, ethanol, tetrahydrofuran, dimethyl formamide). At the end of these reactions, the best efficiency was obtained with the one-pot reaction using THF/DMF, Et3N. The structures of all novel compounds reported herein were established using FT-IR, 1H NMR, and 13C NMR spectra as well as elemental analysis technique.
AU  - Berber, Nurcan
DO  - 10.16984/saufenbilder.950016
PY  - 2022
JO  - Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
VL  - 26
IS  - 4
SN  - 1301-4048
SP  - 757
EP  - 767
DB  - TRDizin
UR  - http://search/yayin/detay/1119890
ER  -