TY  - JOUR
TI  - Evaluation of the Locally and Single Dose  Teriparatide Effect on Masseter Muscle Thickness  and Early Mandibular Bone Healing
AB  - Objective: Bone repair is a multifactorial mechanism  involving a large number of cells, molecules and growth  factors. In this healing period, muscle tissue has an  important role. The aim of the study was to evaluate the  effect of single dose and locally administered teriparatide  on mandibular bone healing and masseter muscle  thickness. Materials and Methods: In this study, 24 Sprague Dawley male rats were used and the experimental animals  were divided into 3 groups. Groups were defined in the  following way: Group-1 had empty defect, Group-2  received 20 μg of TP, and Group-3 received 40 μg of TP.  Before surgery and postoperative 4th week, masseter  muscle thickness was measured with the same ultrasound  imaging system. This was followed by histomorphometric  evaluation that was performed for the measurement of  mandibular bone healing. Results: A statistically significant difference had been  found in terms of the amount of bone ossification area  between Group-1 and Group-2 and between Group-1  and Group-3 (p<0.01), but there was no statistically  significant difference between Group-2 and Group-3  (p>0.01). Increase in the masseter muscle thickness in  the postoperative period was statistically significant in all  groups (p<0.05). On the other hand, increasing in the  masseter muscles thickness was higher in Group-2 and  Group-3 than Group-1 but not statistically significant (p>0.05).  Conclusion: As a result of this study, locally and single  dose administered TP improved bone healing  postoperative 4th week. On the other hand, TP did not  have a significant effect on the increase of masseter  muscle thickness.
AU  - Çiçek, Muhammet Fatih
AU  - Kosehasanogullari, Meryem
AU  - koca, cansu gül
AU  - yıldırım, bengisu
AU  - KAYA, İlhan
AU  - YÜCE, ESRA
DO  - 10.5505/vtd.2021.98048
PY  - 2021
JO  - Van Tıp Dergisi
VL  - 28
IS  - 1
SN  - 1300-2694
SP  - 151
EP  - 158
DB  - TRDizin
UR  - http://search/yayin/detay/1121896
ER  -