Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism

DAĞLI, FATMA; YAZICI, Cevat; Güntürk, İnayet; SEYDEL, GONUL SEYDA

doi:10.17826/cumj.1099652

Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism

Fatma DAĞLI, (Çetin Şen Bilim ve Sanat Merkezi, Kayseri, Türkiye)

İnayet GÜNTÜRK, (Niğde Ömer Halisdemir Üniversitesi, Niğde Zübeyde Hanım Sağlık Yüksekokulu, Ebelik Bölümü, Niğde, Türkiye)

Gonul Seyda SEYDE, (Niğde Ömer Halisdemir Üniversitesi, Sağlık Hizmetleri Daire Başkanlığı, Niğde, Türkiye)

Cevat YAZICI (Erciyes Üniversitesi, Tıp Fakültesi, Klinik Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Cukurova Medical Journal

1 0

Yıl: 2022 Cilt: 47 Sayı: 3 Sayfa Aralığı: 1059 - 1066 Metin Dili: İngilizce DOI: 10.17826/cumj.1099652 İndeks Tarihi: 20-09-2022

Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism

Öz:

Purpose: This study aims to investigate the effects of experimental hyperthyroidism and carnosine which is known to have antioxidant properties on physical and vital findings in rats, and to determine the relationship between these parameters and free T3 (FT3) levels. Materials and Methods: Rats were analyzed in 7 groups (each containing 12 animals); control (CONT), hyperthyroidism-1 (T:10-day L-thyroxine (L-T4) administration), hyperthyroidism-2 (T-T: 20-day L-T4 administration), Carnosine (10 day carnosine administration), Hyperthyroidism-1 + Carnosine (T-C), Hyperthyroidism-2 + Carnosine (T-TC), and Carnosine + Hyperthyroidism-1 (C-T). In order to create a hyperthyroidism model, L-thyroxine (L-T4) doses of 300 µg/kg rat weight/day and carnosine doses of 300 µg/kg rat weight/ day were intraperitoneally (ip) administered to the rats. Results: After 10 and 20 days of thyroxine administration, FT3 levels (T:3.640.51pg/mL, T-T: 4.060.91pg/mL) and body temperature (T:37.10.3oC, T-T: 37.60.3oC), significantly increased while body weight decreased (T:240.722.0g, T-T:263.028.7g). Carnosine administration only prevented the increase of FT3 levels, but had no effect on other parameters. Conclusion: The increased FT3 levels observed with L-T4 administration were consistent with the physical and vital findings, but carnosine administration did not reflect the expected effects on the physical findings observed in the hyperthyroid condition.

Anahtar Kelime: Hyperthyroidism body temperature heart weight body weight carnosine.

Deneysel hipertiroidide fiziksel ve vital bulguların ve karnozinin etkisinin değerlendirilmesi

Öz:

Amaç: Bu çalışmada, deneysel hipertiroidinin ve antioksidan özelliği bilinen karnozinin ratların fiziksel ve vital bulgular üzerine etkilerinin araştırılması; ve bu parametreler ile serbest T3 (FT3) seviyeleri arasındaki ilişkinin belirlenmesi amaçlandı. Gereç ve Yöntem: Ratlar; her biri 12 rattan oluşan (n=12) kontrol (CONT), hipertiroidi 1 (T), hipertiroidi 2 (T-T), Hipertiroidi-1 + Karnozin (T-C), Hipertiroidi-2 + Karnozin (T-TC), Karnozin (C) ve Karnozin + Hipertiroidi-1 (C-T) olmak üzere yedi gruba ayrıldı. Ratlarda hipertiroidi modeli oluşturmak için intraperitoneal (ip) olarak rat ağırlığı/gün başına 300 µg/kg L-tiroksin (L-T4) ve karnozinin etkilerinin belirlenmesi için rat ağırlığı/gün başına 300 µg/kg dozunda karnozin (ip) uygulandı. Bulgular: 10 ve 20 günlük tiroksin uygulaması ile FT3 düzeylerinin (T:3.640.51pg/mL, T-T: 4.060.91pg/mL) ve vücut sıcaklığının (T:37.10.3oC, T-T: 37.60.3oC) anlamlı şekilde arttığı, vücut ağırlığının (T:240.722.0g, T-T:263.028.7g) azaldığı tespit edildi. Karnozin uygulamasının etkileri incelendiğinde, sadece profilaktik uygulamada FT3 düzeylerinin yükselmesini engellediği, diğer parametreler üzerinde iyileştirici etkisinin olmadığı görüldü. Sonuç: L-T4 uygulamasıyla gözlenen artmış FT3 düzeylerinin elde edilen fiziksel ve vital bulgularla uyumlu olduğu ancak karnozin uygulamasının hipertiroidik tabloda gözlenen fiziksel bulgular üzerinde beklenen etkileri yansıtmadığı tespit edildi.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DAĞLI F, Güntürk İ, SEYDEL G, YAZICI C (2022). Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. , 1059 - 1066. 10.17826/cumj.1099652
Chicago	DAĞLI FATMA,Güntürk İnayet,SEYDEL GONUL SEYDA,YAZICI Cevat Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. (2022): 1059 - 1066. 10.17826/cumj.1099652
MLA	DAĞLI FATMA,Güntürk İnayet,SEYDEL GONUL SEYDA,YAZICI Cevat Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. , 2022, ss.1059 - 1066. 10.17826/cumj.1099652
AMA	DAĞLI F,Güntürk İ,SEYDEL G,YAZICI C Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. . 2022; 1059 - 1066. 10.17826/cumj.1099652
Vancouver	DAĞLI F,Güntürk İ,SEYDEL G,YAZICI C Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. . 2022; 1059 - 1066. 10.17826/cumj.1099652
IEEE	DAĞLI F,Güntürk İ,SEYDEL G,YAZICI C "Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism." , ss.1059 - 1066, 2022. 10.17826/cumj.1099652
ISNAD	DAĞLI, FATMA vd. "Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism". (2022), 1059-1066. https://doi.org/10.17826/cumj.1099652

APA	DAĞLI F, Güntürk İ, SEYDEL G, YAZICI C (2022). Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. Cukurova Medical Journal, 47(3), 1059 - 1066. 10.17826/cumj.1099652
Chicago	DAĞLI FATMA,Güntürk İnayet,SEYDEL GONUL SEYDA,YAZICI Cevat Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. Cukurova Medical Journal 47, no.3 (2022): 1059 - 1066. 10.17826/cumj.1099652
MLA	DAĞLI FATMA,Güntürk İnayet,SEYDEL GONUL SEYDA,YAZICI Cevat Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. Cukurova Medical Journal, vol.47, no.3, 2022, ss.1059 - 1066. 10.17826/cumj.1099652
AMA	DAĞLI F,Güntürk İ,SEYDEL G,YAZICI C Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. Cukurova Medical Journal. 2022; 47(3): 1059 - 1066. 10.17826/cumj.1099652
Vancouver	DAĞLI F,Güntürk İ,SEYDEL G,YAZICI C Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism. Cukurova Medical Journal. 2022; 47(3): 1059 - 1066. 10.17826/cumj.1099652
IEEE	DAĞLI F,Güntürk İ,SEYDEL G,YAZICI C "Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism." Cukurova Medical Journal, 47, ss.1059 - 1066, 2022. 10.17826/cumj.1099652
ISNAD	DAĞLI, FATMA vd. "Evaluation of physical and vital signs and the effect of carnosine in experimental hyperthyroidism". Cukurova Medical Journal 47/3 (2022), 1059-1066. https://doi.org/10.17826/cumj.1099652