Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia

Akpınar, Onur; goruroglu ozturk, ozlem; Dişel, Nezihat Rana; Acikalin, Ayca; DAĞLIOĞLU, GÜLÇİN; Matyar, Selçuk

doi:10.17826/cumj.1124909

Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia

Selçuk MATYAR, (Sağlık Bilimleri Üniversitesi, Adana Şehir Eğitim ve Araştırma Hastanesi, Biyokimya Anabilim Dalı, Merkez Laboratuvar, Adana, Türkiye)

Ayca ACİKALİN, (Çukurova Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Adana, Türkiye.)

Nezihat Rana DİŞEL, (Çukurova Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Adana, Türkiye.)

Ozl GORUR, (Çukurova Üniversitesi, Tıp Fakültesi, Balcalı Hastanesi, Biyokimya Anabilim Dalı, Merkez Laboratuvar, Adana, Türkiye)

Gülçin DAĞLIOĞLU, (Çukurova Üniversitesi, Tıp Fakültesi, Balcalı Hastanesi, Biyokimya Anabilim Dalı, Merkez Laboratuvar, Adana, Türkiye)

Onur AKPINAR (Yakın Doğu Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Lefkoşa, Kıbrıs)

Cukurova Medical Journal

6 2

Yıl: 2022 Cilt: 47 Sayı: 3 Sayfa Aralığı: 1147 - 1153 Metin Dili: İngilizce DOI: 10.17826/cumj.1124909 İndeks Tarihi: 20-09-2022

Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia

Öz:

Purpose: In this study, we aimed to investigate the effects of serum neuron specific enolase on the prediction of central nervous system injury and the clinical course in patients to have hyponatremia. Materials and Methods: 75 adult patients with serum sodium levels less than 135 mEq/L were evaluated. The patients were grouped according to serum neuron specific enolase levels (group 1 ≤ 17.0 ng/mL and group 2 > 17.0 ng/mL). The groups were compared according to demographic and laboratory data. Results: The incidence of hypertension, heart failure, and loss of consciousness was significantly higher in group 2 patient. High neuron specific enolase levels were related to lower serum sodium levels. The mean sodium levels were 129.5 ± 4.3 mEq/L and 126 ± 4.5 mEq/L in groups 1 and 2, respectively. Of the patients in group 2 (n = 45), 8 patients with loss of consciousness (low Glasgow Coma Scale scores) (i.e. <15)) had significantly higher serum neuron specific enolase levels than the rest of the patients in group 2 (n = 37) (37.1 ± 6.9 and 18.6 ± 8.8). Conclusion: High neuron specific enolase levels are associated with lower sodium levels and low Glasgow Coma Scale scores. In patients with hyponatremia, we think that neuron specific enolase monitoring can predict which patients may experience a change in consciousness.

Anahtar Kelime: Emergency department Hyponatremia Loss of consciousness Neuron specific enolase

Hiponatremili hastalarda serum nöron spesifik enolaz düzeyleri ile beyin hasarı arasındaki ilişki

Öz:

Amaç: Bu çalışmada hiponatremili hastalarda serum nöron spesifik enolazın santral sinir sistemi hasarını öngörmesi ve klinik gidiş üzerindeki etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Bu prospektif çalışmada, serum sodyum seviyeleri 135 mEq/L'nin altında olan 75 yetişkin hasta değerlendirildi. Hastalar serum nöron spesifik enolaz düzeylerine göre gruplandırıldı (grup 1 ≤ 17.0 ng/mL ve grup 2 > 17.0 ng/mL). Gruplar demografik ve laboratuvar verilerine göre karşılaştırıldı. Bulgular: Grup 2 hastalarında hipertansiyon, kalp yetmezliği ve bilinç kaybı insidansı anlamlı olarak daha yüksekti. Yüksek nöron spesifik enolaz seviyeleri, daha düşük serum sodyum seviyeleri ile ilişkiliydi. Ortalama sodyum seviyeleri grup 1 ve 2'de sırasıyla 129.5 ± 4.3 mEq/L ve 126 ± 4.5 mEq/L idi. Grup 2'deki hastalardan (n = 45), bilinç kaybı olan (düşük Glasgow Koma Skalası skorları) (GKS <15) 8 hastada, grup 2'deki diğer hastalara göre (n = 37) serum nöron spesifik enolaz seviyeleri anlamlı olarak daha yüksekti (37.1 ± 6.9 ve 18.6 ± 8.8). Sonuç: Sonuçlarımız, yüksek nöron spesifik enolaz düzeylerinin daha düşük sodyum düzeyleri ve düşük Glasgow Koma Skalası skorları ile ilişkili olduğunu göstermektedir. Hiponatremili hastalarda nöron spesifik enolaz monitörizasyonunun hangi hastaların bilinç değişikliği yaşayabileceğini öngörebileceğini düşünüyoruz.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Matyar S, Acikalin A, Dişel N, goruroglu ozturk o, DAĞLIOĞLU G, Akpınar O (2022). Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. , 1147 - 1153. 10.17826/cumj.1124909
Chicago	Matyar Selçuk,Acikalin Ayca,Dişel Nezihat Rana,goruroglu ozturk ozlem,DAĞLIOĞLU GÜLÇİN,Akpınar Onur Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. (2022): 1147 - 1153. 10.17826/cumj.1124909
MLA	Matyar Selçuk,Acikalin Ayca,Dişel Nezihat Rana,goruroglu ozturk ozlem,DAĞLIOĞLU GÜLÇİN,Akpınar Onur Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. , 2022, ss.1147 - 1153. 10.17826/cumj.1124909
AMA	Matyar S,Acikalin A,Dişel N,goruroglu ozturk o,DAĞLIOĞLU G,Akpınar O Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. . 2022; 1147 - 1153. 10.17826/cumj.1124909
Vancouver	Matyar S,Acikalin A,Dişel N,goruroglu ozturk o,DAĞLIOĞLU G,Akpınar O Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. . 2022; 1147 - 1153. 10.17826/cumj.1124909
IEEE	Matyar S,Acikalin A,Dişel N,goruroglu ozturk o,DAĞLIOĞLU G,Akpınar O "Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia." , ss.1147 - 1153, 2022. 10.17826/cumj.1124909
ISNAD	Matyar, Selçuk vd. "Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia". (2022), 1147-1153. https://doi.org/10.17826/cumj.1124909

APA	Matyar S, Acikalin A, Dişel N, goruroglu ozturk o, DAĞLIOĞLU G, Akpınar O (2022). Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. Cukurova Medical Journal, 47(3), 1147 - 1153. 10.17826/cumj.1124909
Chicago	Matyar Selçuk,Acikalin Ayca,Dişel Nezihat Rana,goruroglu ozturk ozlem,DAĞLIOĞLU GÜLÇİN,Akpınar Onur Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. Cukurova Medical Journal 47, no.3 (2022): 1147 - 1153. 10.17826/cumj.1124909
MLA	Matyar Selçuk,Acikalin Ayca,Dişel Nezihat Rana,goruroglu ozturk ozlem,DAĞLIOĞLU GÜLÇİN,Akpınar Onur Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. Cukurova Medical Journal, vol.47, no.3, 2022, ss.1147 - 1153. 10.17826/cumj.1124909
AMA	Matyar S,Acikalin A,Dişel N,goruroglu ozturk o,DAĞLIOĞLU G,Akpınar O Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. Cukurova Medical Journal. 2022; 47(3): 1147 - 1153. 10.17826/cumj.1124909
Vancouver	Matyar S,Acikalin A,Dişel N,goruroglu ozturk o,DAĞLIOĞLU G,Akpınar O Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia. Cukurova Medical Journal. 2022; 47(3): 1147 - 1153. 10.17826/cumj.1124909
IEEE	Matyar S,Acikalin A,Dişel N,goruroglu ozturk o,DAĞLIOĞLU G,Akpınar O "Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia." Cukurova Medical Journal, 47, ss.1147 - 1153, 2022. 10.17826/cumj.1124909
ISNAD	Matyar, Selçuk vd. "Relationship between serum neuron specific enolase levels and brain injury in patients with hyponatremia". Cukurova Medical Journal 47/3 (2022), 1147-1153. https://doi.org/10.17826/cumj.1124909