TY  - JOUR
TI  - Change of Lipid Profile and Oxidative Stress Markers with Treatment in Hypogonad Patients
AB  - Aim: To investigate the presence of oxidative stress and dyslipidemia , which increase cardiovascular risk, and the effect of gonadotropin replacement therapy on these parameters in patients with Idiopathic Hypogonadotropic Hypogonadism (IHH). Material and Methods: This was a phase IV, non-randomized, case-controlled study. Male patients diagnosed with IHH (n=30), and a control group of healthy participants with similar age and body mass index (BMI) (n=20) were included. Oxidative stress markers, lipids and apolipoprotein levels were measured before and after gonadotropin treatment and compared with healthy controls. Results: After treatment, a dramatic decrease was obse rved in high-density lipoprotein (HDL), low- density lipoprotein (LDL), advanced oxidation pr otein products (AOPP), malondialdehyde (MDA) and nitric oxide (NO) levels, while a significant increase in thiol level was detected (p<0.05). Conclusion: The data obtained indicated the presence of dyslipidemia and an increase in oxidative stress in hypogonadism cases, and showed that gonadotropin treatment reduced the oxidative stress of patients and positively affected their lipid profile.
AU  - BAŞPINAR, OSMAN
AU  - GÜÇLÜ, KENAN
AU  - baskol, gulden
AU  - bayram, fahri
AU  - AYDOGDU, AYDOGAN
DO  - 10.56615/tkbd.2022.07
PY  - 2022
JO  - Türk Klinik Biyokimya Dergisi
VL  - 20
IS  - 1
SN  - 2980-0749
SP  - 54
EP  - 62
DB  - TRDizin
UR  - http://search/yayin/detay/1122196
ER  -