A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness
Yıl: 2022 Cilt: 47 Sayı: 2 Sayfa Aralığı: 213 - 230 Metin Dili: İngilizce DOI: 10.55262/fabadeczacilik.1134576 İndeks Tarihi: 22-09-2022
A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness
Öz: In this study, it was aimed to develop a topically applicable nanoemulsion (NE) that is expected to have an ameliorating effect in seborrheic dermatitis (SD). The main purpose of the formulation is to eliminate the disease factor, to repair the damage caused by the disease on the skin and to smooth the skin appearance by moisturization. For this reason, in vitro antimicrobial effect and in vivo effectiveness of the formulation were tested. For this aim; essential oils from tea tree, sage, cinnamon, oregano; extracts from Aloe vera, colloidal oatmeal, liquorice; vegetable oils from grape seed and sesame, and honey were used in a NE formulation. The NEs were prepared by ultrasonication method. Preliminary stability tests were applied to all formulations and then, pH, conductivity, viscosity, average droplet size, polydispersity index (PDI), and zeta potential measurements were taken on the selected NEs for 3 months. Finally, the antimicrobial effect and in vivo effectiveness of the optimum NE were tested. The average droplet size, PDI, and zeta potential value of the optimum formulation (F6P2) were 108.40 ± 0.90 nm, 0.195 ± 0.07, and -21.40 ± 1.45 mV, respectively. As a result, the moisture content of the skin increased significantly (p < 0.001), the sebum and redness values significantly decreased (p = 0.008 and 0.001, respectively) and there was no significant change in the pH of the volunteers’ skin. Accordingly, it can be concluded that the optimum NE formulation developed in this study may be beneficial as a supplement for patients with SD.
Anahtar Kelime: Seboreik Dermatite Karşı Kozmetik Bir Nanoemülsiyon: Geliştirme, Karakterizasyon ve Etkinlik
Öz: Bu çalışmada seboreik dermatitte (SD) iyileştirici etkisi olması beklenen topikal olarak uygulanabilir bir nanoemülsiyon (NE) geliştirilmesi amaçlanmıştır. Formülasyonun temel amacı hastalık faktörünü ortadan kaldırmak, hastalığın ciltte verdiği hasarı onarmak ve nemlendirerek cilt görünümünü pürüzsüz hale getirmektir. Bu nedenle formülasyonun in vitro antimikrobiyal etkisi ve in vivo etkinliği test edilmiştir. Bu amaç için NE formülasyonunda; çay ağacı, adaçayı, tarçın, kekik esansiyel yağları; Aloe vera, kolloidal yulaf ezmesi, meyan kökü ekstreleri; üzüm çekirdeği ve susamdan elde edilen bitkisel yağlar ve bal kullanılmıştır. NE’ler ultrasonikasyon yöntemiyle hazırlanmıştır. Tüm formülasyonlara ön stabilite testleri uygulanmış ve ardından seçilen NE’ler üzerinde 3 ay boyunca pH, iletkenlik, viskozite, ortalama damlacık boyutu, polidispersite indeksi (PDI) ve zeta potansiyel ölçümleri alınmıştır. Son olarak, optimum NE’nin antimikrobiyal etkisi ve in vivo etkinliği test edilmiştir. Optimum formülasyonun (F6P2) ortalama damlacık boyutu, PDI ve zeta potansiyel değeri sırasıyla 108,40 ± 0,90 nm, 0,195 ± 0,07 ve -21,40 ± 1,45 mV olarak bulunmuştur. Sonuç olarak, cildin nem içeriği önemli ölçüde artmış (p < 0,001), sebum ve kızarıklık değerleri önemli ölçüde azalmış (sırasıyla p = 0,008 ve 0,001) ve gönüllülerin cildinin pH’ında önemli bir değişiklik meydana gelmemiştir. Buna göre, bu çalışmada geliştirilen optimum NE formülasyonunun SD’li hastalar için ek olarak faydalı olabileceği sonucuna varılabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Dalo F, Yener G, Altuntas E, Dosler s (2022). A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. , 213 - 230. 10.55262/fabadeczacilik.1134576 |
| Chicago | Dalo Feda,Yener Gülgün,Altuntas Ebru,Dosler sibel A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. (2022): 213 - 230. 10.55262/fabadeczacilik.1134576 |
| MLA | Dalo Feda,Yener Gülgün,Altuntas Ebru,Dosler sibel A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. , 2022, ss.213 - 230. 10.55262/fabadeczacilik.1134576 |
| AMA | Dalo F,Yener G,Altuntas E,Dosler s A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. . 2022; 213 - 230. 10.55262/fabadeczacilik.1134576 |
| Vancouver | Dalo F,Yener G,Altuntas E,Dosler s A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. . 2022; 213 - 230. 10.55262/fabadeczacilik.1134576 |
| IEEE | Dalo F,Yener G,Altuntas E,Dosler s "A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness." , ss.213 - 230, 2022. 10.55262/fabadeczacilik.1134576 |
| ISNAD | Dalo, Feda vd. "A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness". (2022), 213-230. https://doi.org/10.55262/fabadeczacilik.1134576 |
| APA | Dalo F, Yener G, Altuntas E, Dosler s (2022). A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. FABAD Journal of Pharmaceutical Sciences, 47(2), 213 - 230. 10.55262/fabadeczacilik.1134576 |
| Chicago | Dalo Feda,Yener Gülgün,Altuntas Ebru,Dosler sibel A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. FABAD Journal of Pharmaceutical Sciences 47, no.2 (2022): 213 - 230. 10.55262/fabadeczacilik.1134576 |
| MLA | Dalo Feda,Yener Gülgün,Altuntas Ebru,Dosler sibel A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. FABAD Journal of Pharmaceutical Sciences, vol.47, no.2, 2022, ss.213 - 230. 10.55262/fabadeczacilik.1134576 |
| AMA | Dalo F,Yener G,Altuntas E,Dosler s A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. FABAD Journal of Pharmaceutical Sciences. 2022; 47(2): 213 - 230. 10.55262/fabadeczacilik.1134576 |
| Vancouver | Dalo F,Yener G,Altuntas E,Dosler s A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness. FABAD Journal of Pharmaceutical Sciences. 2022; 47(2): 213 - 230. 10.55262/fabadeczacilik.1134576 |
| IEEE | Dalo F,Yener G,Altuntas E,Dosler s "A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness." FABAD Journal of Pharmaceutical Sciences, 47, ss.213 - 230, 2022. 10.55262/fabadeczacilik.1134576 |
| ISNAD | Dalo, Feda vd. "A Cosmetic Nanoemulsion Against Seborrheic Dermatitis: Development, Characterization and Effectiveness". FABAD Journal of Pharmaceutical Sciences 47/2 (2022), 213-230. https://doi.org/10.55262/fabadeczacilik.1134576 |
