TY  - JOUR
TI  - Effects of Sedation Doses of Propofol and Midazolam  on Levels of NGAL, Cystatin-C, KIM-1 in Rats
AB  - Limited data are available regarding the impact of their sedation doses midazolam and propofol on early biomarkers of acute kidney  injury (AKI). This study aimed to investigate the effects of sedation doses propofol and midazolam on early biomarkers such as  neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CyC) and kidney injury molecule 1 (KIM-1) of AKI. A total of 24 Wistar albino rats were separated into three groups (n = 8 per group): a control group (intraperitoneal injection [IP]  saline injection once daily for 7 days), a propofol group (IP injection of 2.5 mg/kg propofol once daily for 7 days), and a midazolam  group (IP injection of 5 mg/kg midazolam once daily for 7 days). For each group, urinalysis (for urea, creatinine, total protein,  NGAL, CyC, and KIM-1) was performed on Day 0 and Day 7; serum analysis (for urea, creatinine, total protein, albumin globulin,  ALT, AST, NGAL, CyC, and KIM-1) was performed on day 7.  No significant difference was noted between control, propofol and midazolam groups in terms of Day 7 serum KIM-1, CyC, and  NGAL levels and Day 0 and Day 7 urinalysis findings (KIM-1, CyC, NGAL, urea, and creatinine levels). DISCUSSION AND CONCLUSION: The findings revealed a similar safety profile for seven-day propofol and midazolam  administration in rats in terms of the traditional (creatinine, urea) and early biomarkers (NGAL, CyC, KIM-1) of AKI
AU  - BAŞBUĞAN, Yıldıray
AU  - Soyalp, Celaleddin
AU  - kömüroğlu, ahmet ufuk
AU  - TUNÇDEMİR, Yunus Emre
AU  - YUZKAT, NUREDDIN
DO  - 10.5505/ejm.2022.76376
PY  - 2022
JO  - Eastern Journal of Medicine
VL  - 27
IS  - 3
SN  - 1301-0883
SP  - 370
EP  - 376
DB  - TRDizin
UR  - http://search/yayin/detay/1123878
ER  -