TY  - JOUR
TI  - Effect of Couch Grass (Agropyrum Repens) on  Gentamicin-Induced Nephrotoxicity
AB  - Couch grass is used to clean the urinary tract during infections due to its diuretic and antimicrobial effects. The aim of this study was  to investigate the possible protective or therapeutic effects of couch grass on gentamycin-induced nephrotoxicity in rats. Four groups  of 10 rats were formed in the study. First group, Control: Rats were fed with standard rat feed and water. Second group (couch grass):  3 gr/ L couch grass was added to the drinking water of rats for 7 days. The third group (gentamicin): Gentamicin 80 mg/ kg/ day/  i.p. was given for 7 days. The fourth group (gentamicin + couch grass): Gentamicin 80 mg/ kg/ day/ i.p. and 3 g / L couch grass was  added to drinking water for 7 days. One week after the experimental application, blood samples were taken and serum was separated. Albumin, BUN, creatinine, urea, GGT, ALP, Na, Cl and K levels were determined in autoanalyzer. Cystatin C was measured by  ELISA. Serum BUN, creatinine, urea, Na, K levels were highest in the gentamicin group. Na, K and cystatin C levels differences  between groups were not statistically significant. The increase in BUN, urea and creatinine after gentamicin administration was  statistically significant (p<0.05). The use of gentamycin and couch grass caused BUN, urea and creatinine levels to decrease. The  difference between the groups was found to be statistically significant (p<0.05). The administration of gentamycin and couch grass  decreased cystatin C levels, statistical significance was found between the groups (p<0.05). No statistically significant difference was  found between the groups in albumin, Cl, GGT, ALP levels (p>0.05). As result, positive changes in serum parameters of gentamycin induced nephrotoxicity when couch grass were given, showed that couch grass had a kidney protective effect and decreased  nephrotoxic damage.
AU  - Mert, Handan
AU  - Yurtkulu, Bayram
AU  - ÇIBUK, SALIH
AU  - MERT, Nihat
DO  - 10.5505/ejm.2022.48154
PY  - 2022
JO  - Eastern Journal of Medicine
VL  - 27
IS  - 3
SN  - 1301-0883
SP  - 389
EP  - 393
DB  - TRDizin
UR  - http://search/yayin/detay/1123882
ER  -