Epithelium-off corneal cross-linking versus transepithelial  diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas

Yüksel, Murat; Ozmen, Mehmet; Aydın, Bahri; Uysal, Betul Seher

doi:10.4274/gulhane.galenos.2022.75437

Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas

Betul Seher Uysal, (Gazi Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Murat YÜKSEL, (Gazi Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Mehmet Cüneyt ÖZMEN, (Gazi Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Bahri AYDIN (Gazi Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Gülhane Tıp Dergisi

2 0

Yıl: 2022 Cilt: 64 Sayı: 3 Sayfa Aralığı: 255 - 261 Metin Dili: İngilizce DOI: 10.4274/gulhane.galenos.2022.75437 İndeks Tarihi: 24-09-2022

Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas

Öz:

Aims: To evaluate the efficacy and safety of transepithelial diluted alcohol and iontophoresis assisted corneal cross-linking (DAI-CXL) and compare 24-month visual and topographic outcomes with accelerated CXL using hypo-osmolar riboflavin (A-CXL) in keratoconus patients with thin corneas (below 400 μm with epithelium). Methods: This retrospective study included keratoconus patients who underwent DAI-CXL or A-CXL. Uncorrected and corrected distance visual acuity (UDVA and CDVA) and data obtained from corneal topography were analyzed at baseline and 12 and 24 months of follow-up. Corneal demarcation line depth (DLD) at 1 month and corneal endothelial cell density (ECD) at 24 months were also evaluated. Results: The study included 25 eyes of 25 keratoconus patients (mean age: 25.48±6.69 years, male: 52%). DAI-CXL and A-CXL groups consisted of 13 and 12 patients, respectively. In both groups, median UDVA improved significantly at 24 months (p<0.05) whereas CDVA was similar despite a trend towards improvement. Median K-max decreased by 2.77 [interquartile range (IQR): 2.67] D and 2.24 (IQR: 4.38) D in DAI-CXL group (p=0.033) and A-CXL group (p=0.060), respectively. Corneal HOAs showed a significant improvement in only the DAI-CXL group (p=0.004). Average DLD was 237±67 μm in DAI-CXL and 242±57 μm in A-CXL (p=0.346). No significant changes in ECD were observed in both groups. Median follow-up changes in UDVA, CDVA, K-max, HOAs, and ECD were similar in the groups. Conclusions: We observed similar efficacy of transepithelial DAI-CXL to A-CXL in slowing down the progression of keratoconus in thin corneas without notable effects during a 24-month follow-up period.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Uysal B, Yüksel M, Ozmen M, Aydın B (2022). Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. , 255 - 261. 10.4274/gulhane.galenos.2022.75437
Chicago	Uysal Betul Seher,Yüksel Murat,Ozmen Mehmet,Aydın Bahri Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. (2022): 255 - 261. 10.4274/gulhane.galenos.2022.75437
MLA	Uysal Betul Seher,Yüksel Murat,Ozmen Mehmet,Aydın Bahri Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. , 2022, ss.255 - 261. 10.4274/gulhane.galenos.2022.75437
AMA	Uysal B,Yüksel M,Ozmen M,Aydın B Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. . 2022; 255 - 261. 10.4274/gulhane.galenos.2022.75437
Vancouver	Uysal B,Yüksel M,Ozmen M,Aydın B Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. . 2022; 255 - 261. 10.4274/gulhane.galenos.2022.75437
IEEE	Uysal B,Yüksel M,Ozmen M,Aydın B "Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas." , ss.255 - 261, 2022. 10.4274/gulhane.galenos.2022.75437
ISNAD	Uysal, Betul Seher vd. "Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas". (2022), 255-261. https://doi.org/10.4274/gulhane.galenos.2022.75437

APA	Uysal B, Yüksel M, Ozmen M, Aydın B (2022). Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. Gülhane Tıp Dergisi, 64(3), 255 - 261. 10.4274/gulhane.galenos.2022.75437
Chicago	Uysal Betul Seher,Yüksel Murat,Ozmen Mehmet,Aydın Bahri Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. Gülhane Tıp Dergisi 64, no.3 (2022): 255 - 261. 10.4274/gulhane.galenos.2022.75437
MLA	Uysal Betul Seher,Yüksel Murat,Ozmen Mehmet,Aydın Bahri Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. Gülhane Tıp Dergisi, vol.64, no.3, 2022, ss.255 - 261. 10.4274/gulhane.galenos.2022.75437
AMA	Uysal B,Yüksel M,Ozmen M,Aydın B Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. Gülhane Tıp Dergisi. 2022; 64(3): 255 - 261. 10.4274/gulhane.galenos.2022.75437
Vancouver	Uysal B,Yüksel M,Ozmen M,Aydın B Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas. Gülhane Tıp Dergisi. 2022; 64(3): 255 - 261. 10.4274/gulhane.galenos.2022.75437
IEEE	Uysal B,Yüksel M,Ozmen M,Aydın B "Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas." Gülhane Tıp Dergisi, 64, ss.255 - 261, 2022. 10.4274/gulhane.galenos.2022.75437
ISNAD	Uysal, Betul Seher vd. "Epithelium-off corneal cross-linking versus transepithelial diluted alcohol and iontophoresis-assisted corneal cross linking in keratoconus patients with thin corneas". Gülhane Tıp Dergisi 64/3 (2022), 255-261. https://doi.org/10.4274/gulhane.galenos.2022.75437